CLASP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903690Biological processnegative regulation of wound healing, spreading of epidermal cells
GO_0090091Biological processpositive regulation of extracellular matrix disassembly
GO_0007052Biological processmitotic spindle organization
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0010470Biological processregulation of gastrulation
GO_0051301Biological processcell division
GO_0007020Biological processmicrotubule nucleation
GO_0031111Biological processnegative regulation of microtubule polymerization or depolymerization
GO_0034453Biological processmicrotubule anchoring
GO_0040001Biological processestablishment of mitotic spindle localization
GO_0007026Biological processnegative regulation of microtubule depolymerization
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0090307Biological processmitotic spindle assembly
GO_0007030Biological processGolgi organization
GO_0006903Biological processvesicle targeting
GO_0010458Biological processexit from mitosis
GO_0051893Biological processregulation of focal adhesion assembly
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0051294Biological processestablishment of spindle orientation
GO_1904261Biological processpositive regulation of basement membrane assembly involved in embryonic body morphogenesis
GO_0030953Biological processastral microtubule organization
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0010717Biological processregulation of epithelial to mesenchymal transition
GO_0031023Biological processmicrotubule organizing center organization
GO_0001578Biological processmicrotubule bundle formation
GO_0045921Biological processpositive regulation of exocytosis
GO_0010634Biological processpositive regulation of epithelial cell migration
GO_0051497Biological processnegative regulation of stress fiber assembly
GO_0005876Cellular componentspindle microtubule
GO_0072686Cellular componentmitotic spindle
GO_0016020Cellular componentmembrane
GO_0031592Cellular componentcentrosomal corona
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0005815Cellular componentmicrotubule organizing center
GO_0035371Cellular componentmicrotubule plus-end
GO_0045180Cellular componentbasal cortex
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0030981Cellular componentcortical microtubule cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005828Cellular componentkinetochore microtubule
GO_0005938Cellular componentcell cortex
GO_0005881Cellular componentcytoplasmic microtubule
GO_0051010Molecular functionmicrotubule plus-end binding
GO_0002162Molecular functiondystroglycan binding
GO_0043515Molecular functionkinetochore binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCLASP1
Protein nameCytoplasmic linker associated protein 1
CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1)
SynonymsKIAA0622
MAST1
DescriptionFUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. .

AccessionsC9JP76
ENST00000418989.5
ENST00000455322.7
ENST00000696935.1
ENST00000409078.8 [Q7Z460-2]
Q7Z460
C9J151
ENST00000263710.8 [Q7Z460-1]
A0A8V8TLP7
ENST00000700755.1
F8WA11
ENST00000541377.5 [Q7Z460-4]
H0Y5T1
ENST00000452274.7
ENST00000700754.1
A0A8V8TQK9
ENST00000449975.1
A0A8V8TRF6