CNN3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	52% ± 19%	Explore
fibroblast	44 studies	52% ± 20%	Explore
pericyte	38 studies	54% ± 22%	Explore
smooth muscle cell	29 studies	52% ± 17%	Explore
endothelial cell of lymphatic vessel	27 studies	64% ± 22%	Explore
astrocyte	23 studies	41% ± 16%	Explore
basal cell	20 studies	37% ± 16%	Explore
epithelial cell	18 studies	36% ± 15%	Explore
connective tissue cell	18 studies	58% ± 20%	Explore
capillary endothelial cell	15 studies	50% ± 19%	Explore
myofibroblast cell	14 studies	68% ± 19%	Explore
vein endothelial cell	14 studies	55% ± 15%	Explore
endothelial cell of artery	13 studies	37% ± 15%	Explore
endothelial cell of vascular tree	13 studies	57% ± 11%	Explore
oligodendrocyte precursor cell	12 studies	36% ± 19%	Explore
type I pneumocyte	11 studies	37% ± 15%	Explore
secretory cell	11 studies	44% ± 12%	Explore
type II pneumocyte	9 studies	27% ± 14%	Explore
ciliated cell	9 studies	32% ± 11%	Explore
club cell	8 studies	31% ± 11%	Explore
mesothelial cell	7 studies	48% ± 19%	Explore
glial cell	7 studies	56% ± 23%	Explore
ionocyte	6 studies	56% ± 19%	Explore
epithelial cell of proximal tubule	6 studies	36% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	35% ± 6%	Explore
renal alpha-intercalated cell	6 studies	59% ± 16%	Explore
abnormal cell	6 studies	47% ± 18%	Explore
Mueller cell	6 studies	54% ± 24%	Explore
GABAergic neuron	5 studies	22% ± 3%	Explore
transit amplifying cell	5 studies	26% ± 6%	Explore
brush cell	5 studies	38% ± 18%	Explore
Schwann cell	5 studies	59% ± 24%	Explore
neuron	5 studies	47% ± 20%	Explore
adventitial cell	5 studies	42% ± 16%	Explore
duct epithelial cell	4 studies	23% ± 4%	Explore
respiratory goblet cell	4 studies	37% ± 18%	Explore
squamous epithelial cell	4 studies	38% ± 20%	Explore
glomerular endothelial cell	4 studies	78% ± 6%	Explore
progenitor cell	4 studies	44% ± 25%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	45% ± 4%	Explore
retinal pigment epithelial cell	4 studies	52% ± 25%	Explore
mucus secreting cell	4 studies	27% ± 9%	Explore
muscle cell	4 studies	50% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	47% ± 5%	Explore
myoepithelial cell	4 studies	50% ± 14%	Explore
luminal cell of prostate epithelium	4 studies	35% ± 9%	Explore
glutamatergic neuron	4 studies	26% ± 7%	Explore
intestinal crypt stem cell	4 studies	32% ± 3%	Explore
oligodendrocyte	4 studies	17% ± 1%	Explore
hepatocyte	4 studies	39% ± 18%	Explore
interneuron	4 studies	24% ± 8%	Explore
podocyte	3 studies	50% ± 7%	Explore
neural crest cell	3 studies	74% ± 15%	Explore
renal principal cell	3 studies	43% ± 7%	Explore
placental villous trophoblast	3 studies	48% ± 7%	Explore
serous secreting cell	3 studies	26% ± 2%	Explore
lymphocyte	3 studies	59% ± 27%	Explore
chondrocyte	3 studies	45% ± 29%	Explore
endothelial cell of sinusoid	3 studies	50% ± 29%	Explore
pancreatic ductal cell	3 studies	60% ± 18%	Explore
ependymal cell	3 studies	50% ± 18%	Explore
enteroendocrine cell	3 studies	36% ± 10%	Explore
goblet cell	3 studies	22% ± 4%	Explore
melanocyte	3 studies	31% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	11 studies	33% ± 16%	Explore
brain	11 studies	23% ± 5%	Explore
kidney	7 studies	33% ± 9%	Explore
eye	7 studies	27% ± 11%	Explore
intestine	6 studies	35% ± 15%	Explore
uterus	5 studies	36% ± 10%	Explore
prostate	5 studies	36% ± 15%	Explore
placenta	4 studies	33% ± 7%	Explore
breast	4 studies	34% ± 12%	Explore
heart	3 studies	23% ± 7%	Explore
skin	3 studies	29% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	9674.29	2627 / 2642	100%	666.87	703 / 705
ovary	100%	15297.17	180 / 180	99%	187.37	425 / 430
kidney	100%	17454.33	89 / 89	99%	295.69	890 / 901
thymus	100%	14175.31	652 / 653	98%	237.98	594 / 605
breast	100%	17343.21	459 / 459	98%	273.82	1092 / 1118
uterus	100%	21046.92	170 / 170	96%	231.51	440 / 459
lung	100%	21298.35	578 / 578	95%	187.78	1103 / 1155
prostate	100%	13552.15	244 / 245	95%	164.95	479 / 502
intestine	100%	12081.40	966 / 966	91%	130.90	482 / 527
bladder	100%	12011.71	21 / 21	91%	165.81	457 / 504
skin	96%	8662.86	1733 / 1809	93%	257.22	441 / 472
adrenal gland	100%	25384.91	258 / 258	88%	140.93	202 / 230
liver	94%	5152.47	213 / 226	92%	137.91	374 / 406
stomach	100%	9517.02	358 / 359	86%	121.49	246 / 286
esophagus	100%	12450.70	1445 / 1445	79%	85.89	144 / 183
pancreas	81%	3806.20	265 / 328	97%	185.69	172 / 178
adipose	100%	16989.84	1204 / 1204	0%	0	0 / 0
blood vessel	100%	16876.61	1335 / 1335	0%	0	0 / 0
spleen	96%	5504.61	232 / 241	0%	0	0 / 0
heart	93%	6993.23	804 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	148.72	42 / 45
eye	0%	0	0 / 0	65%	56.57	52 / 80
muscle	16%	625.13	127 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	14%	8.05	4 / 29
peripheral blood	4%	132.57	36 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0098609	Biological process	cell-cell adhesion
GO_0007015	Biological process	actin filament organization
GO_0030855	Biological process	epithelial cell differentiation
GO_0031032	Biological process	actomyosin structure organization
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005912	Cellular component	adherens junction
GO_0005925	Cellular component	focal adhesion
GO_0005516	Molecular function	calmodulin binding
GO_0098641	Molecular function	cadherin binding involved in cell-cell adhesion
GO_0051015	Molecular function	actin filament binding

IV. Literature review

[source]

Gene name	CNN3
Protein name	Calponin Calponin-3 (Calponin, acidic isoform) DJ639P13.2.2 (Acidic calponin 3)
Synonyms
Description	FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. .
Accessions	Q15417 ENST00000545882.5 [Q15417-2] E9PDU6 ENST00000394202.8 [Q15417-3] ENST00000370206.9 [Q15417-1] ENST00000415017.1 Q9BWY6

CNN3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review