BCAR3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	13 studies	27% ± 11%	Explore
astrocyte	11 studies	42% ± 21%	Explore
microglial cell	10 studies	30% ± 13%	Explore
adipocyte	9 studies	35% ± 8%	Explore
endothelial cell of lymphatic vessel	5 studies	25% ± 8%	Explore
macrophage	5 studies	31% ± 6%	Explore
epithelial cell	4 studies	26% ± 3%	Explore
glutamatergic neuron	4 studies	32% ± 8%	Explore
type I pneumocyte	4 studies	21% ± 5%	Explore
pericyte	4 studies	23% ± 6%	Explore
mesothelial cell	3 studies	36% ± 12%	Explore
GABAergic neuron	3 studies	34% ± 10%	Explore
capillary endothelial cell	3 studies	27% ± 7%	Explore
fibroblast	3 studies	26% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	26% ± 8%	Explore
adipose	3 studies	24% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2615.12	459 / 459	97%	20.24	1088 / 1118
stomach	100%	1081.98	359 / 359	97%	8.02	278 / 286
intestine	100%	1468.50	966 / 966	97%	9.08	509 / 527
kidney	100%	1507.16	89 / 89	96%	10.19	865 / 901
thymus	100%	1557.65	652 / 653	96%	11.40	580 / 605
bladder	100%	1914.05	21 / 21	96%	14.59	482 / 504
lung	100%	2068.97	578 / 578	95%	11.56	1097 / 1155
ovary	100%	1194.52	180 / 180	95%	9.69	408 / 430
skin	100%	2344.84	1808 / 1809	95%	19.74	448 / 472
uterus	100%	963.87	170 / 170	94%	16.03	430 / 459
esophagus	99%	1244.32	1432 / 1445	95%	12.66	173 / 183
brain	97%	998.22	2564 / 2642	96%	9.19	674 / 705
prostate	100%	1309.36	245 / 245	92%	7.00	464 / 502
adrenal gland	98%	1390.23	254 / 258	88%	11.24	203 / 230
liver	94%	635.70	212 / 226	88%	7.48	358 / 406
pancreas	35%	135.59	114 / 328	97%	17.93	173 / 178
adipose	100%	2681.00	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	7.39	1 / 1
blood vessel	100%	1574.74	1333 / 1335	0%	0	0 / 0
muscle	100%	1769.10	801 / 803	0%	0	0 / 0
spleen	99%	601.61	238 / 241	0%	0	0 / 0
heart	98%	1037.42	844 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	15.62	28 / 29
tonsil	0%	0	0 / 0	91%	8.80	41 / 45
eye	0%	0	0 / 0	53%	3.12	42 / 80
peripheral blood	9%	52.96	79 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0007173	Biological process	epidermal growth factor receptor signaling pathway
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0086100	Biological process	endothelin receptor signaling pathway
GO_0002089	Biological process	lens morphogenesis in camera-type eye
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0008286	Biological process	insulin receptor signaling pathway
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005925	Cellular component	focal adhesion
GO_0019900	Molecular function	kinase binding
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0005515	Molecular function	protein binding
GO_0001784	Molecular function	phosphotyrosine residue binding

IV. Literature review

[source]

Gene name	BCAR3
Protein name	Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)
Synonyms	NSP2 UNQ271/PRO308 SH2D3B
Description	FUNCTION: Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers . Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis . Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 . Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis . Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 . .
Accessions	ENST00000539242.5 [O75815-2] ENST00000370247.7 [O75815-3] ENST00000260502.11 [O75815-1] ENST00000370244.5 [O75815-1] O75815 ENST00000370243.1 [O75815-1]

BCAR3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review