Insufficient scRNA-seq data for expression of NPHS1 at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 100% | 2752.09 | 328 / 328 | 40% | 1.59 | 72 / 178 |
| kidney | 96% | 7279.47 | 85 / 89 | 12% | 0.54 | 105 / 901 |
| stomach | 76% | 48.28 | 273 / 359 | 10% | 0.21 | 29 / 286 |
| brain | 84% | 46.51 | 2230 / 2642 | 1% | 0.01 | 5 / 705 |
| lymph node | 0% | 0 | 0 / 0 | 34% | 2.26 | 10 / 29 |
| adipose | 31% | 39.46 | 377 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 28% | 6.46 | 67 / 241 | 0% | 0 | 0 / 0 |
| intestine | 17% | 7.72 | 169 / 966 | 7% | 0.18 | 35 / 527 |
| thymus | 11% | 6.92 | 72 / 653 | 12% | 0.42 | 72 / 605 |
| ovary | 11% | 3.83 | 19 / 180 | 12% | 1.57 | 53 / 430 |
| uterus | 13% | 3.54 | 22 / 170 | 6% | 0.40 | 28 / 459 |
| adrenal gland | 4% | 0.62 | 11 / 258 | 12% | 0.35 | 28 / 230 |
| esophagus | 4% | 0.85 | 64 / 1445 | 9% | 0.24 | 17 / 183 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 0.47 | 6 / 45 |
| lung | 6% | 0.93 | 35 / 578 | 7% | 0.24 | 77 / 1155 |
| skin | 4% | 0.79 | 78 / 1809 | 6% | 0.21 | 27 / 472 |
| prostate | 9% | 1.87 | 21 / 245 | 0% | 0.00 | 1 / 502 |
| breast | 4% | 1.21 | 18 / 459 | 3% | 0.10 | 36 / 1118 |
| heart | 5% | 1.24 | 46 / 861 | 0% | 0 | 0 / 0 |
| liver | 1% | 0.20 | 3 / 226 | 3% | 0.24 | 11 / 406 |
| blood vessel | 4% | 1.76 | 49 / 1335 | 0% | 0 | 0 / 0 |
| bladder | 0% | 0 | 0 / 21 | 3% | 0.10 | 14 / 504 |
| peripheral blood | 2% | 0.40 | 22 / 929 | 0% | 0 | 0 / 0 |
| muscle | 2% | 0.32 | 16 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007254 | Biological process | JNK cascade |
| GO_0030838 | Biological process | positive regulation of actin filament polymerization |
| GO_0007519 | Biological process | skeletal muscle tissue development |
| GO_0032836 | Biological process | glomerular basement membrane development |
| GO_0072015 | Biological process | podocyte development |
| GO_0036060 | Biological process | slit diaphragm assembly |
| GO_0010467 | Biological process | gene expression |
| GO_0007520 | Biological process | myoblast fusion |
| GO_0035418 | Biological process | protein localization to synapse |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_0036057 | Cellular component | slit diaphragm |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0042995 | Cellular component | cell projection |
| GO_0017022 | Molecular function | myosin binding |
| GO_0050839 | Molecular function | cell adhesion molecule binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NPHS1 |
| Protein name | Nephrin Nephrin (Renal glomerulus-specific cell adhesion receptor) Truncated NPHS1 |
| Synonyms | NPHN |
| Description | FUNCTION: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity). . |
| Accessions | ENST00000353632.6 [O60500-2] O60500 A0A1B2JLU5 A0A125S6H6 ENST00000378910.10 [O60500-1] A0A125S6H5 A0A125S6H7 |
