HACD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0007254Biological processJNK cascade
GO_0042761Biological processvery long-chain fatty acid biosynthetic process
GO_0030497Biological processfatty acid elongation
GO_0046726Biological processpositive regulation by virus of viral protein levels in host cell
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0045070Biological processpositive regulation of viral genome replication
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0016601Biological processRac protein signal transduction
GO_0007266Biological processRho protein signal transduction
GO_1902532Biological processnegative regulation of intracellular signal transduction
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005925Cellular componentfocal adhesion
GO_0005783Cellular componentendoplasmic reticulum
GO_0031965Cellular componentnuclear membrane
GO_0019899Molecular functionenzyme binding
GO_0018812Molecular function3-hydroxyacyl-CoA dehydratase activity
GO_0005096Molecular functionGTPase activator activity
GO_0005515Molecular functionprotein binding
GO_0102158Molecular functionvery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity

IV. Literature review

[source]
Gene nameHACD3
Protein nameVery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134)
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 3) (HACD3) (Butyrate-induced protein 1) (B-ind1) (hB-ind1) (Protein-tyrosine phosphatase-like A domain-containing protein 1)
SynonymsBIND1
PTPLAD1
DescriptionFUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization . .

FUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .

FUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .

FUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .

FUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .

AccessionsH3BS72
ENST00000442729.6 [Q9P035-2]
Q9P035
H3BPZ1
ENST00000569894.5
ENST00000562832.1
ENST00000562901.5
ENST00000261875.10 [Q9P035-1]
H3BMZ1
ENST00000568793.5
H3BRL8
ENST00000566511.5
ENST00000565299.5
ENST00000566074.5