CBL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033574Biological processresponse to testosterone
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0016567Biological processprotein ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0042059Biological processnegative regulation of epidermal growth factor receptor signaling pathway
GO_0070086Biological processubiquitin-dependent endocytosis
GO_0010332Biological processresponse to gamma radiation
GO_0007165Biological processsignal transduction
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0051865Biological processprotein autoubiquitination
GO_0014823Biological processresponse to activity
GO_0045471Biological processresponse to ethanol
GO_2000583Biological processregulation of platelet-derived growth factor receptor-alpha signaling pathway
GO_0042594Biological processresponse to starvation
GO_0048260Biological processpositive regulation of receptor-mediated endocytosis
GO_0043303Biological processmast cell degranulation
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0032487Biological processregulation of Rap protein signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0035635Biological processentry of bacterium into host cell
GO_0008584Biological processmale gonad development
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007175Biological processnegative regulation of epidermal growth factor-activated receptor activity
GO_0006513Biological processprotein monoubiquitination
GO_0036120Biological processcellular response to platelet-derived growth factor stimulus
GO_0071456Biological processcellular response to hypoxia
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0016600Cellular componentflotillin complex
GO_0005925Cellular componentfocal adhesion
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0030426Cellular componentgrowth cone
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0046875Molecular functionephrin receptor binding
GO_0045296Molecular functioncadherin binding
GO_0036312Molecular functionphosphatidylinositol 3-kinase regulatory subunit binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameCBL
Protein nameE3 ubiquitin-protein ligase CBL (EC 2.3.2.27)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Alternative protein CBL
Cbl proto-oncogene
SynonymsCBL2
RNF55
DescriptionFUNCTION: Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome . Ubiquitinates SPRY2 . Ubiquitinates EGFR . Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

AccessionsA0A1B0GW38
A0A8V8TQA9
A0A0U1RR39
ENST00000637974.1
ENST00000634301.1
P22681
ENST00000264033.6
A0A0U1RQX8
ENST00000700472.1
A0A0U1RRJ5
L0R4V5
ENST00000634840.1
ENST00000634586.1