FES | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
classical monocyte	15 studies	28% ± 12%	Explore
macrophage	10 studies	20% ± 6%	Explore
conventional dendritic cell	8 studies	29% ± 19%	Explore
dendritic cell	7 studies	29% ± 15%	Explore
endothelial cell of artery	5 studies	20% ± 6%	Explore
plasmacytoid dendritic cell	5 studies	20% ± 5%	Explore
endothelial cell	4 studies	21% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	17% ± 2%	Explore
non-classical monocyte	3 studies	21% ± 2%	Explore
common myeloid progenitor	3 studies	25% ± 5%	Explore
myeloid cell	3 studies	25% ± 3%	Explore
monocyte	3 studies	22% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	3 studies	21% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	2548.21	652 / 653	100%	20.54	605 / 605
ovary	100%	1855.88	180 / 180	99%	16.64	426 / 430
lung	100%	4580.06	578 / 578	97%	15.90	1121 / 1155
prostate	100%	2828.55	245 / 245	97%	13.00	485 / 502
breast	100%	3072.39	459 / 459	96%	11.68	1072 / 1118
uterus	99%	2860.30	169 / 170	95%	16.15	436 / 459
bladder	100%	2227.62	21 / 21	94%	15.09	474 / 504
kidney	98%	1531.84	87 / 89	93%	13.39	836 / 901
skin	92%	980.59	1672 / 1809	97%	27.89	458 / 472
liver	100%	1878.82	225 / 226	90%	18.48	364 / 406
intestine	100%	1742.22	964 / 966	85%	8.23	448 / 527
adrenal gland	98%	1127.13	253 / 258	79%	6.60	181 / 230
stomach	87%	1098.04	314 / 359	89%	8.67	254 / 286
esophagus	90%	1385.39	1298 / 1445	83%	7.21	152 / 183
pancreas	66%	556.36	216 / 328	98%	20.46	175 / 178
brain	60%	488.46	1581 / 2642	95%	10.27	670 / 705
adipose	100%	3931.41	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	22.30	80 / 80
lymph node	0%	0	0 / 0	100%	25.99	29 / 29
spleen	100%	16059.39	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	11.03	1 / 1
heart	99%	1473.89	856 / 861	0%	0	0 / 0
blood vessel	99%	1729.47	1326 / 1335	0%	0	0 / 0
peripheral blood	95%	9906.05	879 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	9.83	42 / 45
muscle	48%	346.58	382 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010976	Biological process	positive regulation of neuron projection development
GO_0071305	Biological process	cellular response to vitamin D
GO_0043304	Biological process	regulation of mast cell degranulation
GO_0060627	Biological process	regulation of vesicle-mediated transport
GO_0006935	Biological process	chemotaxis
GO_0007155	Biological process	cell adhesion
GO_0045657	Biological process	positive regulation of monocyte differentiation
GO_0031116	Biological process	positive regulation of microtubule polymerization
GO_0007098	Biological process	centrosome cycle
GO_0060038	Biological process	cardiac muscle cell proliferation
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_0051450	Biological process	myoblast proliferation
GO_0045595	Biological process	regulation of cell differentiation
GO_2000145	Biological process	regulation of cell motility
GO_0008360	Biological process	regulation of cell shape
GO_0045639	Biological process	positive regulation of myeloid cell differentiation
GO_0006468	Biological process	protein phosphorylation
GO_0046777	Biological process	protein autophosphorylation
GO_0030155	Biological process	regulation of cell adhesion
GO_0001578	Biological process	microtubule bundle formation
GO_0042127	Biological process	regulation of cell population proliferation
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0005737	Cellular component	cytoplasm
GO_0004715	Molecular function	non-membrane spanning protein tyrosine kinase activity
GO_0034987	Molecular function	immunoglobulin receptor binding
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0035091	Molecular function	phosphatidylinositol binding
GO_0008017	Molecular function	microtubule binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	FES
Protein name	Fes/fps proto-oncogene FES proto-oncogene, tyrosine kinase C-fes/fps protein Tyrosine-protein kinase (EC 2.7.10.2) Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)
Synonyms	FPS
Description	FUNCTION: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. .
Accessions	ENST00000559355.5 E7EMJ7 ENST00000394300.7 [P07332-3] Q4JFK7 ENST00000443697.1 Q4JFK8 ENST00000414248.6 [P07332-2] H0YNT6 H0YNN8 ENST00000394302.5 C9J3W6 ENST00000444422.2 [P07332-4] ENST00000464684.5 E9PIJ7 ENST00000470152.6 P07332 ENST00000328850.8 [P07332-1] E7ENM8 ENST00000452243.5 ENST00000416779.1 E9PGC7

FES report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review