SSH2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	28 studies	31% ± 15%	Explore
B cell	27 studies	36% ± 17%	Explore
endothelial cell	26 studies	39% ± 16%	Explore
macrophage	21 studies	44% ± 23%	Explore
non-classical monocyte	20 studies	36% ± 13%	Explore
classical monocyte	19 studies	29% ± 10%	Explore
CD8-positive, alpha-beta T cell	19 studies	28% ± 11%	Explore
T cell	18 studies	34% ± 18%	Explore
memory B cell	18 studies	26% ± 6%	Explore
naive B cell	18 studies	30% ± 9%	Explore
CD4-positive, alpha-beta T cell	17 studies	31% ± 13%	Explore
astrocyte	16 studies	37% ± 16%	Explore
regulatory T cell	16 studies	27% ± 10%	Explore
oligodendrocyte	15 studies	65% ± 14%	Explore
oligodendrocyte precursor cell	15 studies	45% ± 17%	Explore
microglial cell	15 studies	70% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	34% ± 12%	Explore
monocyte	12 studies	44% ± 26%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	29% ± 14%	Explore
glutamatergic neuron	12 studies	63% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	33% ± 15%	Explore
mature NK T cell	12 studies	26% ± 13%	Explore
pericyte	12 studies	34% ± 18%	Explore
GABAergic neuron	11 studies	62% ± 21%	Explore
mucosal invariant T cell	11 studies	28% ± 13%	Explore
dendritic cell	11 studies	43% ± 21%	Explore
fibroblast	11 studies	44% ± 13%	Explore
myeloid cell	10 studies	44% ± 21%	Explore
smooth muscle cell	10 studies	34% ± 13%	Explore
gamma-delta T cell	10 studies	26% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	26% ± 8%	Explore
adipocyte	9 studies	61% ± 13%	Explore
endothelial cell of lymphatic vessel	9 studies	44% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	22% ± 6%	Explore
neutrophil	8 studies	39% ± 25%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	33% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	25% ± 7%	Explore
epithelial cell	8 studies	37% ± 19%	Explore
mast cell	8 studies	36% ± 16%	Explore
neuron	7 studies	52% ± 23%	Explore
interneuron	6 studies	68% ± 16%	Explore
ciliated cell	6 studies	27% ± 8%	Explore
type I pneumocyte	6 studies	45% ± 13%	Explore
type II pneumocyte	6 studies	59% ± 14%	Explore
basal cell	6 studies	34% ± 22%	Explore
leukocyte	5 studies	64% ± 24%	Explore
conventional dendritic cell	5 studies	32% ± 17%	Explore
lymphocyte	5 studies	46% ± 25%	Explore
plasmacytoid dendritic cell	5 studies	24% ± 3%	Explore
pro-B cell	5 studies	30% ± 5%	Explore
capillary endothelial cell	5 studies	28% ± 15%	Explore
cardiac muscle cell	5 studies	57% ± 13%	Explore
mesothelial cell	5 studies	32% ± 13%	Explore
T follicular helper cell	5 studies	27% ± 5%	Explore
innate lymphoid cell	5 studies	31% ± 17%	Explore
club cell	5 studies	37% ± 14%	Explore
plasmablast	4 studies	31% ± 13%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	48% ± 20%	Explore
granule cell	4 studies	57% ± 11%	Explore
precursor B cell	4 studies	24% ± 6%	Explore
plasma cell	4 studies	40% ± 8%	Explore
immature B cell	4 studies	23% ± 6%	Explore
amacrine cell	4 studies	35% ± 8%	Explore
retina horizontal cell	4 studies	42% ± 7%	Explore
retinal cone cell	4 studies	34% ± 6%	Explore
retinal ganglion cell	4 studies	48% ± 13%	Explore
retinal rod cell	4 studies	38% ± 3%	Explore
alveolar macrophage	4 studies	62% ± 25%	Explore
goblet cell	4 studies	31% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	31% ± 18%	Explore
abnormal cell	4 studies	29% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	19% ± 5%	Explore
GABAergic interneuron	3 studies	58% ± 6%	Explore
glial cell	3 studies	39% ± 6%	Explore
progenitor cell	3 studies	36% ± 5%	Explore
mononuclear phagocyte	3 studies	55% ± 23%	Explore
vein endothelial cell	3 studies	32% ± 10%	Explore
GABAergic amacrine cell	3 studies	38% ± 10%	Explore
Mueller cell	3 studies	30% ± 14%	Explore
OFF-bipolar cell	3 studies	30% ± 11%	Explore
ON-bipolar cell	3 studies	30% ± 6%	Explore
glycinergic amacrine cell	3 studies	33% ± 10%	Explore
intermediate monocyte	3 studies	48% ± 14%	Explore
endothelial cell of vascular tree	3 studies	33% ± 5%	Explore
hepatocyte	3 studies	56% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore
neural progenitor cell	3 studies	34% ± 15%	Explore
connective tissue cell	3 studies	25% ± 5%	Explore
respiratory goblet cell	3 studies	52% ± 19%	Explore
group 3 innate lymphoid cell	3 studies	21% ± 4%	Explore
double negative thymocyte	3 studies	35% ± 10%	Explore
mural cell	3 studies	51% ± 11%	Explore
mucus secreting cell	3 studies	39% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	54% ± 22%	Explore
peripheral blood	13 studies	28% ± 7%	Explore
lung	8 studies	39% ± 17%	Explore
heart	5 studies	45% ± 16%	Explore
eye	5 studies	41% ± 12%	Explore
kidney	5 studies	27% ± 9%	Explore
bone marrow	4 studies	24% ± 10%	Explore
lymph node	4 studies	22% ± 5%	Explore
liver	4 studies	34% ± 14%	Explore
adipose	4 studies	49% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	1854.48	21 / 21	99%	7.91	501 / 504
lung	100%	7213.05	578 / 578	99%	9.69	1148 / 1155
thymus	100%	2679.00	651 / 653	99%	9.56	601 / 605
skin	99%	2337.09	1796 / 1809	99%	12.13	468 / 472
esophagus	99%	2106.53	1424 / 1445	99%	11.11	182 / 183
breast	98%	2775.75	452 / 459	99%	10.15	1108 / 1118
stomach	96%	1846.66	346 / 359	100%	8.64	286 / 286
intestine	97%	2900.35	940 / 966	99%	7.81	522 / 527
kidney	96%	1743.43	85 / 89	97%	14.20	874 / 901
uterus	92%	1613.87	157 / 170	99%	7.87	456 / 459
brain	90%	1777.18	2379 / 2642	100%	11.49	703 / 705
prostate	87%	1520.74	213 / 245	90%	4.07	451 / 502
adrenal gland	92%	1672.63	237 / 258	85%	3.49	195 / 230
pancreas	57%	707.63	187 / 328	98%	8.36	175 / 178
ovary	43%	612.59	78 / 180	96%	4.65	411 / 430
liver	50%	598.60	113 / 226	69%	2.94	280 / 406
eye	0%	0	0 / 0	100%	15.19	80 / 80
lymph node	0%	0	0 / 0	100%	13.79	29 / 29
muscle	100%	16988.67	803 / 803	0%	0	0 / 0
peripheral blood	100%	16087.43	929 / 929	0%	0	0 / 0
spleen	100%	10324.22	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.58	45 / 45
ureter	0%	0	0 / 0	100%	4.04	1 / 1
adipose	100%	3834.91	1203 / 1204	0%	0	0 / 0
heart	95%	2578.89	820 / 861	0%	0	0 / 0
blood vessel	76%	1384.78	1017 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030036	Biological process	actin cytoskeleton organization
GO_0030837	Biological process	negative regulation of actin filament polymerization
GO_0007283	Biological process	spermatogenesis
GO_0006470	Biological process	protein dephosphorylation
GO_0030154	Biological process	cell differentiation
GO_0005615	Cellular component	extracellular space
GO_0005856	Cellular component	cytoskeleton
GO_0001669	Cellular component	acrosomal vesicle
GO_0005925	Cellular component	focal adhesion
GO_0005737	Cellular component	cytoplasm
GO_0004721	Molecular function	phosphoprotein phosphatase activity
GO_0003779	Molecular function	actin binding
GO_0017018	Molecular function	myosin phosphatase activity
GO_0004725	Molecular function	protein tyrosine phosphatase activity

IV. Literature review

[source]

Gene name	SSH2
Protein name	Slingshot homolog 2 (Drosophila), isoform CRA_a (Slingshot protein phosphatase 2) Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) Alternative protein SSH2 Slingshot protein phosphatase 2 protein-serine/threonine phosphatase (EC 3.1.3.16)
Synonyms	KIAA1725 SSH2L hCG_2003225
Description	FUNCTION: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein . Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). .
Accessions	ENST00000577991.1 A0A3B3ITS1 J3KSQ9 ENST00000324677.12 ENST00000592397.1 J3KSP5 ENST00000579954.1 ENST00000590153.1 L8E929 ENST00000582084.1 K7EKN7 ENST00000540801.6 Q76I76 K7EQZ0 F5H527 ENST00000579040.5 K7EP00 ENST00000269033.7 [Q76I76-1] A0A3B3IS79 ENST00000649863.1

SSH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review