ACTN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	39 studies	32% ± 11%	Explore
endothelial cell	38 studies	32% ± 13%	Explore
smooth muscle cell	33 studies	53% ± 18%	Explore
pericyte	31 studies	39% ± 15%	Explore
endothelial cell of lymphatic vessel	24 studies	49% ± 15%	Explore
macrophage	17 studies	23% ± 7%	Explore
myofibroblast cell	15 studies	50% ± 18%	Explore
classical monocyte	14 studies	26% ± 9%	Explore
endothelial cell of vascular tree	14 studies	32% ± 12%	Explore
vein endothelial cell	13 studies	46% ± 14%	Explore
connective tissue cell	13 studies	34% ± 11%	Explore
basal cell	12 studies	27% ± 14%	Explore
ciliated cell	11 studies	25% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	27% ± 10%	Explore
platelet	10 studies	42% ± 12%	Explore
conventional dendritic cell	10 studies	24% ± 5%	Explore
adipocyte	10 studies	31% ± 10%	Explore
monocyte	9 studies	25% ± 10%	Explore
neutrophil	8 studies	25% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	23% ± 6%	Explore
alveolar macrophage	7 studies	29% ± 10%	Explore
glutamatergic neuron	7 studies	54% ± 21%	Explore
endothelial cell of artery	7 studies	20% ± 3%	Explore
megakaryocyte	6 studies	67% ± 21%	Explore
epithelial cell	6 studies	34% ± 18%	Explore
CD4-positive, alpha-beta T cell	6 studies	29% ± 10%	Explore
type I pneumocyte	6 studies	19% ± 1%	Explore
retinal cone cell	6 studies	37% ± 6%	Explore
myeloid cell	5 studies	36% ± 7%	Explore
CD8-positive, alpha-beta T cell	5 studies	34% ± 11%	Explore
cardiac muscle cell	5 studies	21% ± 3%	Explore
abnormal cell	5 studies	30% ± 8%	Explore
deuterosomal cell	4 studies	25% ± 7%	Explore
neuron	4 studies	34% ± 13%	Explore
retinal bipolar neuron	4 studies	20% ± 2%	Explore
capillary endothelial cell	4 studies	21% ± 2%	Explore
mesothelial cell	4 studies	18% ± 2%	Explore
retinal rod cell	4 studies	21% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	38% ± 10%	Explore
astrocyte	4 studies	24% ± 3%	Explore
GABAergic neuron	4 studies	37% ± 14%	Explore
brush cell	4 studies	42% ± 16%	Explore
goblet cell	4 studies	32% ± 8%	Explore
myoepithelial cell	4 studies	79% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 2%	Explore
ionocyte	3 studies	32% ± 9%	Explore
pancreatic A cell	3 studies	40% ± 14%	Explore
extravillous trophoblast	3 studies	51% ± 9%	Explore
placental villous trophoblast	3 studies	29% ± 8%	Explore
common myeloid progenitor	3 studies	22% ± 4%	Explore
dendritic cell	3 studies	36% ± 14%	Explore
rod bipolar cell	3 studies	32% ± 1%	Explore
hepatocyte	3 studies	48% ± 22%	Explore
muscle cell	3 studies	70% ± 20%	Explore
hematopoietic precursor cell	3 studies	30% ± 14%	Explore
enteroendocrine cell	3 studies	24% ± 6%	Explore
intestinal crypt stem cell	3 studies	19% ± 4%	Explore
secretory cell	3 studies	20% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	12 studies	23% ± 10%	Explore
brain	7 studies	35% ± 19%	Explore
eye	7 studies	21% ± 6%	Explore
intestine	6 studies	24% ± 9%	Explore
uterus	4 studies	27% ± 9%	Explore
breast	4 studies	28% ± 8%	Explore
pancreas	3 studies	37% ± 16%	Explore
placenta	3 studies	34% ± 9%	Explore
heart	3 studies	22% ± 1%	Explore
liver	3 studies	27% ± 11%	Explore
prostate	3 studies	21% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	99%	43001.22	168 / 170	99%	103.19	453 / 459
breast	98%	20498.77	448 / 459	100%	114.90	1113 / 1118
lung	97%	18476.75	563 / 578	99%	90.39	1139 / 1155
prostate	94%	28621.69	231 / 245	99%	92.69	496 / 502
esophagus	90%	56647.11	1300 / 1445	100%	139.16	183 / 183
bladder	95%	54224.14	20 / 21	94%	90.37	476 / 504
intestine	88%	51048.50	848 / 966	99%	97.24	524 / 527
skin	74%	18536.23	1339 / 1809	98%	123.67	462 / 472
ovary	61%	8757.48	109 / 180	99%	83.74	427 / 430
stomach	59%	25699.85	212 / 359	99%	109.48	284 / 286
thymus	34%	3774.31	221 / 653	91%	40.96	550 / 605
adrenal gland	38%	3987.65	99 / 258	80%	53.06	183 / 230
liver	35%	3803.63	79 / 226	82%	39.56	334 / 406
kidney	29%	3969.58	26 / 89	85%	48.32	768 / 901
pancreas	16%	1697.74	51 / 328	99%	127.12	176 / 178
blood vessel	100%	86300.11	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	98%	49.43	78 / 80
adipose	96%	17470.69	1156 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	78.90	42 / 45
brain	24%	2773.41	628 / 2642	67%	48.78	472 / 705
peripheral blood	75%	16754.62	699 / 929	0%	0	0 / 0
heart	65%	10595.48	561 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	62%	21.13	18 / 29
spleen	49%	5393.62	119 / 241	0%	0	0 / 0
muscle	2%	260.33	17 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0099173	Biological process	postsynapse organization
GO_0070527	Biological process	platelet aggregation
GO_0055001	Biological process	muscle cell development
GO_0051639	Biological process	actin filament network formation
GO_0030168	Biological process	platelet activation
GO_0051017	Biological process	actin filament bundle assembly
GO_0030036	Biological process	actin cytoskeleton organization
GO_0042981	Biological process	regulation of apoptotic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0007015	Biological process	actin filament organization
GO_0036344	Biological process	platelet morphogenesis
GO_0048041	Biological process	focal adhesion assembly
GO_0030220	Biological process	platelet formation
GO_0001726	Cellular component	ruffle
GO_0005903	Cellular component	brush border
GO_0005615	Cellular component	extracellular space
GO_0098978	Cellular component	glutamatergic synapse
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0030018	Cellular component	Z disc
GO_0005916	Cellular component	fascia adherens
GO_0070062	Cellular component	extracellular exosome
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0005884	Cellular component	actin filament
GO_0005925	Cellular component	focal adhesion
GO_0005911	Cellular component	cell-cell junction
GO_0001725	Cellular component	stress fiber
GO_0005829	Cellular component	cytosol
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0005737	Cellular component	cytoplasm
GO_0042995	Cellular component	cell projection
GO_0031143	Cellular component	pseudopodium
GO_0030054	Cellular component	cell junction
GO_0042803	Molecular function	protein homodimerization activity
GO_0051015	Molecular function	actin filament binding
GO_0005178	Molecular function	integrin binding
GO_0099186	Molecular function	structural constituent of postsynapse
GO_0017166	Molecular function	vinculin binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005509	Molecular function	calcium ion binding
GO_0030374	Molecular function	nuclear receptor coactivator activity
GO_0005515	Molecular function	protein binding
GO_0003725	Molecular function	double-stranded RNA binding

IV. Literature review

[source]

Gene name	ACTN1
Protein name	ACTN1 protein Actinin alpha 1 Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) Alpha-actinin 1
Synonyms	hCG_22243
Description	FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. . FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. .
Accessions	ENST00000684638.1 A0A804HJN7 A0A804HLD0 ENST00000438964.6 [P12814-2] A0A024R694 A1L0V1 Q5ZEZ4 G3V2E8 A0A804HIN7 ENST00000544964.6 ENST00000684639.1 G3V2N5 A0A804HJQ9 ENST00000538545.6 [P12814-4] A0A804HJU8 P12814 H0YJW3 G3V5M4 A0A804HK61 G3V2W4 A0A804HIY0 ENST00000683342.1 G3V2X9 ENST00000682331.1 ENST00000553370.5 ENST00000553659.1 A0A804HLF4 ENST00000682291.1 H9KV75 ENST00000556433.5 ENST00000679147.1 ENST00000554508.6 ENST00000555075.5 ENST00000394419.9 [P12814-3] H7C5W8 ENST00000193403.10 [P12814-1] ENST00000684182.1 ENST00000555616.5 G3V380 ENST00000376839.7 A0A7I2V4Y4 ENST00000683198.1 ENST00000683225.1 H0YJ11 ENST00000553290.1 ENST00000684713.1 A0A804HL31 ENST00000683267.1 ENST00000553779.5 A0A804HKE2 A0A804HII9 ENST00000684598.1 ENST00000556571.1 ENST00000682559.1

ACTN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review