GRB7 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of GRB7 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	2058.08	328 / 328	96%	53.69	171 / 178
lung	93%	1161.31	539 / 578	96%	54.60	1109 / 1155
kidney	100%	4130.66	89 / 89	82%	30.31	740 / 901
prostate	88%	1728.00	215 / 245	94%	21.32	470 / 502
thymus	97%	829.60	633 / 653	80%	33.43	481 / 605
stomach	75%	1320.03	269 / 359	95%	79.13	273 / 286
breast	61%	1828.82	279 / 459	95%	66.69	1061 / 1118
bladder	48%	691.29	10 / 21	96%	82.19	482 / 504
intestine	41%	508.06	399 / 966	98%	82.16	514 / 527
esophagus	39%	2155.78	564 / 1445	98%	130.53	179 / 183
liver	81%	610.78	182 / 226	49%	17.76	198 / 406
ovary	8%	41.86	14 / 180	100%	117.44	428 / 430
uterus	19%	184.84	33 / 170	88%	73.72	402 / 459
tonsil	0%	0	0 / 0	100%	57.11	45 / 45
ureter	0%	0	0 / 0	100%	51.16	1 / 1
skin	72%	2855.85	1305 / 1809	2%	0.37	10 / 472
adipose	28%	296.69	343 / 1204	0%	0	0 / 0
brain	17%	200.14	462 / 2642	0%	0.03	2 / 705
lymph node	0%	0	0 / 0	10%	2.23	3 / 29
heart	3%	18.24	26 / 861	0%	0	0 / 0
blood vessel	1%	5.79	12 / 1335	0%	0	0 / 0
adrenal gland	0%	0	0 / 258	1%	0.28	2 / 230
muscle	0%	2.19	4 / 803	0%	0	0 / 0
peripheral blood	0%	3.15	4 / 929	0%	0	0 / 0
spleen	0%	1.47	1 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007173	Biological process	epidermal growth factor receptor signaling pathway
GO_0008286	Biological process	insulin receptor signaling pathway
GO_0030335	Biological process	positive regulation of cell migration
GO_0017148	Biological process	negative regulation of translation
GO_0034063	Biological process	stress granule assembly
GO_0046627	Biological process	negative regulation of insulin receptor signaling pathway
GO_0042995	Cellular component	cell projection
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0010494	Cellular component	cytoplasmic stress granule
GO_0005925	Cellular component	focal adhesion
GO_0019901	Molecular function	protein kinase binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0035091	Molecular function	phosphatidylinositol binding
GO_0003723	Molecular function	RNA binding

Gene name	GRB7
Protein name	Growth factor receptor-bound protein 7 isoform 2 Growth factor receptor-bound protein 7 isoform 1 Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) Growth factor receptor bound protein 7
Synonyms
Description	FUNCTION: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). .
Accessions	ENST00000394211.7 [Q14451-1] J3QKK7 ENST00000445327.6 [Q14451-3] A0A0S2Z4F6 A0A0S2Z3V3 ENST00000583813.1 ENST00000577695.5 J3QL76 ENST00000394209.6 [Q14451-1] ENST00000394204.1 [Q14451-2] Q14451 ENST00000309156.9 [Q14451-1]

GRB7 report