HMGA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0090402Biological processoncogene-induced cell senescence
GO_0006268Biological processDNA unwinding involved in DNA replication
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006337Biological processnucleosome disassembly
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035985Cellular componentsenescence-associated heterochromatin focus
GO_0005654Cellular componentnucleoplasm
GO_0005925Cellular componentfocal adhesion
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140677Molecular functionmolecular function activator activity
GO_0008301Molecular functionDNA binding, bending
GO_0060090Molecular functionmolecular adaptor activity
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0001221Molecular functiontranscription coregulator binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0030527Molecular functionstructural constituent of chromatin
GO_0046965Molecular functionnuclear retinoid X receptor binding
GO_0042974Molecular functionnuclear retinoic acid receptor binding
GO_0003680Molecular functionminor groove of adenine-thymine-rich DNA binding
GO_0042975Molecular functionperoxisome proliferator activated receptor binding
GO_0003723Molecular functionRNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHMGA1
Protein nameHigh mobility group protein HMG-I/HMG-Y (High mobility group AT-hook protein 1)
High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R)
High mobility group AT-hook 1
SynonymsHMGIY
DescriptionFUNCTION: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

FUNCTION: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. .

FUNCTION: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. .

FUNCTION: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. .

FUNCTION: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. .

AccessionsENST00000703808.1
ENST00000374116.3 [P17096-2]
Q6IPL9
A0A994J705
ENST00000703809.1
ENST00000674029.1
P17096
ENST00000347617.10 [P17096-2]
A0A994J434
ENST00000311487.9 [P17096-1]
Q5T6U8
ENST00000447654.5 [P17096-1]
A0A669KAX1
ENST00000401473.7 [P17096-2]