ABCB4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ABCB4 at tissue level.

III. Associated gene sets

GO_0055085Biological processtransmembrane transport
GO_1901557Biological processresponse to fenofibrate
GO_0061092Biological processpositive regulation of phospholipid translocation
GO_1903413Biological processcellular response to bile acid
GO_0032376Biological processpositive regulation of cholesterol transport
GO_2001140Biological processpositive regulation of phospholipid transport
GO_0045332Biological processphospholipid translocation
GO_0099040Biological processceramide translocation
GO_0055088Biological processlipid homeostasis
GO_0006629Biological processlipid metabolic process
GO_0032782Biological processbile acid secretion
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0046581Cellular componentintercellular canaliculus
GO_0090554Molecular functionphosphatidylcholine floppase activity
GO_0140359Molecular functionABC-type transporter activity
GO_0099038Molecular functionceramide floppase activity
GO_0005548Molecular functionphospholipid transporter activity
GO_0005524Molecular functionATP binding
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCB4
Protein nameABCB4 protein (ATP-binding cassette, sub-family B (MDR/TAP), member 4, isoform CRA_b)
Variant ATP-binding cassette sub-family B member 4
ATP-binding cassette sub-family B member 4
ATP binding cassette subfamily B member 4
Mutant ATP-binding cassette sub-family B member 4
Phosphatidylcholine translocator ABCB4 (EC 7.6.2.1) (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (P-glycoprotein 3)
MDR3 (EC 3.6.3.44)
Truncated ATP-binding cassette sub-family B member 4
ATP-binding cassette, sub-family B (MDR/TAP), member 4
Uncharacterized protein ABCB4
SynonymsPGY3
MDR3
hCG_1743207
DescriptionFUNCTION: [Isoform 1]: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts . Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes . Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner . Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane . In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts . Does not confer multidrug resistance (By similarity). .

AccessionsE7EQI1
H7C0M2
Q4G0Q4
A7J1R1
A7J1R6
A7J1S0
Q6PJ81
ENST00000643670.1
E5LR39
V5N6U4
ENST00000453593.5 [P21439-3]
A7J1Q4
ENST00000359206.8 [P21439-2]
A8HT68
A7J1Q8
A7J1R8
A7J1R0
A7J1S4
A0A2R8Y291
A7J1Q7
Q75MQ5
A7J1S3
A7J1R5
A7J1Q6
ENST00000265723.8 [P21439-1]
A7J1Q9
ENST00000644106.1
A7J1Q3
ENST00000440025.1
A7J1S2
ENST00000417608.1
A7J1R3
A7J1R7
ENST00000649586.2 [P21439-2]
A7J1R4
A7J1Q5
A8HT72
A7J1R9
A7J1S1
A7J1R2
P21439
A0A2R8Y8A1
A7K6Y6
A7J1S5