HSPA9 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	31 studies	29% ± 11%	Explore
B cell	28 studies	25% ± 6%	Explore
fibroblast	28 studies	28% ± 12%	Explore
endothelial cell	27 studies	29% ± 11%	Explore
CD8-positive, alpha-beta T cell	27 studies	28% ± 10%	Explore
macrophage	26 studies	25% ± 8%	Explore
T cell	25 studies	27% ± 11%	Explore
CD4-positive, alpha-beta T cell	25 studies	29% ± 12%	Explore
pericyte	22 studies	25% ± 8%	Explore
smooth muscle cell	21 studies	27% ± 8%	Explore
conventional dendritic cell	21 studies	29% ± 14%	Explore
basal cell	19 studies	31% ± 12%	Explore
regulatory T cell	19 studies	29% ± 11%	Explore
classical monocyte	17 studies	23% ± 9%	Explore
mast cell	16 studies	27% ± 10%	Explore
epithelial cell	16 studies	36% ± 20%	Explore
naive B cell	15 studies	25% ± 7%	Explore
memory B cell	15 studies	30% ± 10%	Explore
monocyte	14 studies	20% ± 4%	Explore
mature NK T cell	14 studies	26% ± 7%	Explore
gamma-delta T cell	14 studies	34% ± 13%	Explore
plasmacytoid dendritic cell	13 studies	32% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	32% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	31% ± 11%	Explore
ciliated cell	12 studies	32% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	25% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	28% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	33% ± 8%	Explore
connective tissue cell	12 studies	26% ± 7%	Explore
astrocyte	12 studies	29% ± 10%	Explore
non-classical monocyte	11 studies	25% ± 10%	Explore
myofibroblast cell	11 studies	25% ± 7%	Explore
mucosal invariant T cell	11 studies	33% ± 10%	Explore
dendritic cell	10 studies	34% ± 19%	Explore
endothelial cell of lymphatic vessel	10 studies	25% ± 7%	Explore
endothelial cell of vascular tree	10 studies	25% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	29% ± 9%	Explore
abnormal cell	9 studies	34% ± 15%	Explore
plasma cell	8 studies	35% ± 17%	Explore
plasmablast	8 studies	44% ± 18%	Explore
vein endothelial cell	8 studies	21% ± 8%	Explore
myeloid cell	8 studies	30% ± 11%	Explore
secretory cell	7 studies	27% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	27% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	34% ± 8%	Explore
epithelial cell of proximal tubule	7 studies	29% ± 6%	Explore
microglial cell	7 studies	23% ± 8%	Explore
GABAergic neuron	7 studies	35% ± 20%	Explore
type I pneumocyte	6 studies	23% ± 8%	Explore
hematopoietic precursor cell	6 studies	38% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	28% ± 6%	Explore
leukocyte	6 studies	29% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	29% ± 6%	Explore
renal alpha-intercalated cell	6 studies	37% ± 5%	Explore
neuron	6 studies	29% ± 15%	Explore
transit amplifying cell	6 studies	30% ± 15%	Explore
glutamatergic neuron	6 studies	43% ± 23%	Explore
innate lymphoid cell	6 studies	27% ± 6%	Explore
adipocyte	6 studies	24% ± 8%	Explore
T follicular helper cell	6 studies	27% ± 7%	Explore
oligodendrocyte precursor cell	6 studies	29% ± 11%	Explore
goblet cell	6 studies	27% ± 9%	Explore
ionocyte	5 studies	31% ± 10%	Explore
mononuclear phagocyte	5 studies	25% ± 9%	Explore
progenitor cell	5 studies	30% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	38% ± 4%	Explore
erythroblast	5 studies	39% ± 16%	Explore
hematopoietic stem cell	5 studies	35% ± 7%	Explore
precursor B cell	5 studies	27% ± 9%	Explore
type II pneumocyte	5 studies	26% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	32% ± 12%	Explore
oligodendrocyte	5 studies	27% ± 9%	Explore
deuterosomal cell	4 studies	26% ± 6%	Explore
pancreatic A cell	4 studies	43% ± 8%	Explore
exhausted T cell	4 studies	28% ± 5%	Explore
retinal ganglion cell	4 studies	59% ± 23%	Explore
lymphocyte	4 studies	32% ± 11%	Explore
club cell	4 studies	29% ± 8%	Explore
capillary endothelial cell	4 studies	22% ± 8%	Explore
immature B cell	4 studies	26% ± 2%	Explore
retina horizontal cell	4 studies	30% ± 9%	Explore
retinal cone cell	4 studies	27% ± 12%	Explore
retinal rod cell	4 studies	24% ± 8%	Explore
Mueller cell	4 studies	32% ± 9%	Explore
endothelial cell of artery	4 studies	22% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	31% ± 6%	Explore
hepatocyte	4 studies	45% ± 25%	Explore
granulocyte	4 studies	26% ± 4%	Explore
alveolar macrophage	4 studies	23% ± 3%	Explore
erythrocyte	4 studies	37% ± 22%	Explore
interneuron	4 studies	38% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	26% ± 7%	Explore
hillock cell	3 studies	26% ± 5%	Explore
respiratory goblet cell	3 studies	36% ± 17%	Explore
type B pancreatic cell	3 studies	48% ± 13%	Explore
enterocyte	3 studies	19% ± 1%	Explore
intestinal crypt stem cell	3 studies	30% ± 8%	Explore
neural crest cell	3 studies	24% ± 1%	Explore
retinal bipolar neuron	3 studies	31% ± 10%	Explore
placental villous trophoblast	3 studies	39% ± 7%	Explore
common myeloid progenitor	3 studies	34% ± 14%	Explore
pro-B cell	3 studies	27% ± 7%	Explore
retinal pigment epithelial cell	3 studies	44% ± 15%	Explore
cardiac muscle cell	3 studies	20% ± 3%	Explore
ON-bipolar cell	3 studies	30% ± 14%	Explore
rod bipolar cell	3 studies	30% ± 7%	Explore
intermediate monocyte	3 studies	34% ± 20%	Explore
CD4-positive helper T cell	3 studies	33% ± 15%	Explore
muscle cell	3 studies	36% ± 9%	Explore
pancreatic ductal cell	3 studies	56% ± 17%	Explore
granulocyte monocyte progenitor cell	3 studies	37% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	49% ± 16%	Explore
enteroendocrine cell	3 studies	28% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 10%	Explore
T-helper 17 cell	3 studies	31% ± 7%	Explore
T-helper 1 cell	3 studies	30% ± 1%	Explore
double negative thymocyte	3 studies	45% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	21% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	25% ± 8%	Explore
peripheral blood	15 studies	29% ± 9%	Explore
eye	9 studies	28% ± 11%	Explore
brain	9 studies	34% ± 16%	Explore
kidney	8 studies	26% ± 4%	Explore
intestine	8 studies	21% ± 7%	Explore
liver	6 studies	28% ± 15%	Explore
uterus	5 studies	30% ± 10%	Explore
pancreas	4 studies	40% ± 14%	Explore
bone marrow	4 studies	26% ± 5%	Explore
lymph node	4 studies	29% ± 7%	Explore
breast	4 studies	26% ± 6%	Explore
prostate	4 studies	24% ± 6%	Explore
placenta	3 studies	30% ± 3%	Explore
adrenal gland	3 studies	24% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	35703.83	258 / 258	100%	165.74	230 / 230
breast	100%	12570.32	459 / 459	100%	131.03	1118 / 1118
intestine	100%	11970.81	966 / 966	100%	111.15	527 / 527
kidney	100%	15143.03	89 / 89	100%	117.38	901 / 901
liver	100%	17507.35	226 / 226	100%	120.56	406 / 406
ovary	100%	13026.18	180 / 180	100%	69.79	430 / 430
stomach	100%	11658.86	359 / 359	100%	94.75	286 / 286
uterus	100%	10376.48	170 / 170	100%	93.23	459 / 459
esophagus	100%	11263.65	1444 / 1445	100%	81.81	183 / 183
bladder	100%	12410.10	21 / 21	100%	88.77	503 / 504
prostate	100%	10174.16	245 / 245	100%	108.27	501 / 502
brain	100%	12359.75	2635 / 2642	100%	120.29	705 / 705
lung	100%	11087.79	576 / 578	100%	85.10	1155 / 1155
thymus	100%	12736.18	653 / 653	99%	87.65	601 / 605
skin	100%	15681.15	1809 / 1809	99%	130.73	468 / 472
pancreas	100%	7255.36	327 / 328	99%	69.53	177 / 178
adipose	100%	13136.47	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	95.64	29 / 29
muscle	100%	26391.03	803 / 803	0%	0	0 / 0
spleen	100%	9323.40	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	102.95	45 / 45
ureter	0%	0	0 / 0	100%	21.43	1 / 1
blood vessel	100%	10803.54	1333 / 1335	0%	0	0 / 0
heart	96%	16817.19	829 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	84.57	77 / 80
peripheral blood	54%	8102.76	500 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903707	Biological process	negative regulation of hemopoiesis
GO_0006611	Biological process	protein export from nucleus
GO_0045647	Biological process	negative regulation of erythrocyte differentiation
GO_0007007	Biological process	inner mitochondrial membrane organization
GO_1902037	Biological process	negative regulation of hematopoietic stem cell differentiation
GO_0006886	Biological process	intracellular protein transport
GO_0030218	Biological process	erythrocyte differentiation
GO_0016226	Biological process	iron-sulfur cluster assembly
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0045646	Biological process	regulation of erythrocyte differentiation
GO_0042026	Biological process	protein refolding
GO_0051085	Biological process	chaperone cofactor-dependent protein refolding
GO_0036444	Biological process	calcium import into the mitochondrion
GO_0005730	Cellular component	nucleolus
GO_0042645	Cellular component	mitochondrial nucleoid
GO_0001401	Cellular component	SAM complex
GO_0005739	Cellular component	mitochondrion
GO_0070062	Cellular component	extracellular exosome
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005925	Cellular component	focal adhesion
GO_0005759	Cellular component	mitochondrial matrix
GO_0140275	Cellular component	MIB complex
GO_0005737	Cellular component	cytoplasm
GO_0005744	Cellular component	TIM23 mitochondrial import inner membrane translocase complex
GO_0005634	Cellular component	nucleus
GO_0044183	Molecular function	protein folding chaperone
GO_0031072	Molecular function	heat shock protein binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0051082	Molecular function	unfolded protein binding
GO_0140662	Molecular function	ATP-dependent protein folding chaperone
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	HSPA9
Protein name	Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (Heat shock 70 kDa protein 9) Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) Heat shock protein family A (Hsp70) member 9
Synonyms	hCG_18779 mt-HSP70 HSPA9B GRP75
Description	FUNCTION: Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU . Regulates erythropoiesis via stabilization of ISC assembly . May play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 . May play a role in the control of cell proliferation and cellular aging (By similarity). .
Accessions	ENST00000512328.1 ENST00000677988.1 ENST00000677066.1 H0Y8K0 A0A7I2V2S7 ENST00000678051.1 A0A7I2V3F7 ENST00000677064.1 ENST00000678300.1 A0A3B3ITI4 ENST00000649578.2 ENST00000678384.1 ENST00000677527.1 A0A7I2YQB2 A0A7I2V4A9 ENST00000507115.6 P38646 D6RCD7 H0Y8S0 ENST00000677693.1 A0A7I2YQQ5 ENST00000678794.1 Q8N1C8 A0A7I2V3D9 A0A7I2V2G2 A0A7I2V2K6 ENST00000677553.1 ENST00000297185.9 ENST00000677425.1 ENST00000504902.6

HSPA9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review