SYNPO2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
smooth muscle cell	34 studies	47% ± 21%	Explore
pericyte	24 studies	35% ± 16%	Explore
fibroblast	18 studies	35% ± 18%	Explore
myofibroblast cell	12 studies	37% ± 19%	Explore
glutamatergic neuron	10 studies	42% ± 24%	Explore
endothelial cell	7 studies	30% ± 8%	Explore
cardiac muscle cell	6 studies	63% ± 24%	Explore
astrocyte	6 studies	40% ± 16%	Explore
neuron	5 studies	24% ± 7%	Explore
connective tissue cell	5 studies	26% ± 9%	Explore
muscle cell	4 studies	58% ± 24%	Explore
GABAergic neuron	3 studies	47% ± 13%	Explore
interneuron	3 studies	51% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
heart	6 studies	36% ± 17%	Explore
brain	6 studies	38% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	85%	54631.97	208 / 245	98%	64.38	494 / 502
esophagus	83%	110775.46	1198 / 1445	61%	18.32	111 / 183
breast	67%	13449.67	309 / 459	74%	9.59	825 / 1118
uterus	96%	43983.93	163 / 170	36%	13.89	164 / 459
bladder	86%	100976.48	18 / 21	41%	9.60	208 / 504
intestine	78%	92842.29	752 / 966	48%	8.26	253 / 527
stomach	56%	48361.26	202 / 359	59%	30.44	169 / 286
muscle	100%	190659.56	801 / 803	0%	0	0 / 0
blood vessel	97%	73826.02	1297 / 1335	0%	0	0 / 0
adipose	70%	18235.79	842 / 1204	0%	0	0 / 0
ovary	44%	8793.88	80 / 180	22%	1.97	93 / 430
brain	0%	29.50	4 / 2642	65%	5.32	460 / 705
pancreas	0%	0	0 / 328	65%	12.93	116 / 178
kidney	4%	722.73	4 / 89	59%	9.01	532 / 901
adrenal gland	1%	147.93	2 / 258	61%	5.44	141 / 230
thymus	8%	1683.73	52 / 653	53%	3.45	318 / 605
tonsil	0%	0	0 / 0	60%	15.06	27 / 45
lung	11%	1953.87	66 / 578	38%	15.19	438 / 1155
skin	10%	1990.62	182 / 1809	23%	3.08	108 / 472
heart	32%	7348.89	277 / 861	0%	0	0 / 0
liver	0%	56.88	1 / 226	12%	0.69	49 / 406
lymph node	0%	0	0 / 0	7%	0.31	2 / 29
spleen	1%	119.86	2 / 241	0%	0	0 / 0
peripheral blood	0%	20.68	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0032233	Biological process	positive regulation of actin filament bundle assembly
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0001725	Cellular component	stress fiber
GO_0015629	Cellular component	actin cytoskeleton
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005925	Cellular component	focal adhesion
GO_0030018	Cellular component	Z disc
GO_0005634	Cellular component	nucleus
GO_0051393	Molecular function	alpha-actinin binding
GO_0051371	Molecular function	muscle alpha-actinin binding
GO_0071889	Molecular function	14-3-3 protein binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding
GO_0031005	Molecular function	filamin binding

IV. Literature review

[source]

Gene name	SYNPO2
Protein name	Synaptopodin 2 (cDNA FLJ52650, moderately similar to Synaptopodin-2) Synaptopodin-2 (Genethonin-2) (Myopodin) Synaptopodin 2
Synonyms
Description	FUNCTION: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner . At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration . May be a tumor suppressor . .; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. .; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. .; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. .; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. .; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia . Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. .
Accessions	ENST00000627783.2 [Q9UMS6-5] ENST00000434046.6 [Q9UMS6-3] ENST00000610556.4 [Q9UMS6-4] B9EG60 B4E258 ENST00000504178.1 ENST00000448416.6 ENST00000307142.9 [Q9UMS6-2] ENST00000429713.7 [Q9UMS6-1] H0Y9Y3 Q9UMS6

SYNPO2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review