FLNA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	38 studies	47% ± 19%	Explore
fibroblast	38 studies	36% ± 15%	Explore
pericyte	37 studies	51% ± 20%	Explore
smooth muscle cell	34 studies	65% ± 21%	Explore
endothelial cell	31 studies	31% ± 10%	Explore
CD8-positive, alpha-beta T cell	28 studies	39% ± 20%	Explore
classical monocyte	27 studies	56% ± 16%	Explore
T cell	26 studies	35% ± 17%	Explore
non-classical monocyte	25 studies	61% ± 18%	Explore
B cell	23 studies	24% ± 7%	Explore
macrophage	23 studies	38% ± 17%	Explore
regulatory T cell	22 studies	35% ± 12%	Explore
CD4-positive, alpha-beta T cell	22 studies	33% ± 14%	Explore
monocyte	20 studies	46% ± 17%	Explore
conventional dendritic cell	20 studies	41% ± 18%	Explore
dendritic cell	19 studies	41% ± 16%	Explore
gamma-delta T cell	17 studies	42% ± 16%	Explore
mature NK T cell	17 studies	45% ± 15%	Explore
memory B cell	15 studies	25% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	58% ± 19%	Explore
myofibroblast cell	15 studies	61% ± 15%	Explore
endothelial cell of lymphatic vessel	14 studies	27% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	37% ± 12%	Explore
mucosal invariant T cell	14 studies	41% ± 15%	Explore
basal cell	14 studies	26% ± 7%	Explore
connective tissue cell	14 studies	36% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	42% ± 15%	Explore
myeloid cell	13 studies	40% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	24% ± 5%	Explore
endothelial cell of artery	12 studies	28% ± 13%	Explore
vein endothelial cell	12 studies	27% ± 10%	Explore
type I pneumocyte	11 studies	43% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	45% ± 14%	Explore
platelet	11 studies	56% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	35% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	34% ± 9%	Explore
capillary endothelial cell	10 studies	23% ± 9%	Explore
type II pneumocyte	9 studies	21% ± 10%	Explore
alveolar macrophage	8 studies	49% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	52% ± 19%	Explore
mesothelial cell	8 studies	27% ± 12%	Explore
epithelial cell	8 studies	28% ± 12%	Explore
plasmablast	7 studies	42% ± 15%	Explore
naive B cell	7 studies	20% ± 4%	Explore
endothelial cell of vascular tree	7 studies	32% ± 19%	Explore
innate lymphoid cell	6 studies	34% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	42% ± 15%	Explore
megakaryocyte	6 studies	65% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	49% ± 18%	Explore
CD4-positive helper T cell	5 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	49% ± 10%	Explore
exhausted T cell	5 studies	49% ± 20%	Explore
neutrophil	5 studies	32% ± 9%	Explore
leukocyte	5 studies	29% ± 9%	Explore
progenitor cell	5 studies	35% ± 12%	Explore
abnormal cell	5 studies	37% ± 12%	Explore
mononuclear phagocyte	5 studies	30% ± 8%	Explore
double negative thymocyte	5 studies	47% ± 21%	Explore
intermediate monocyte	5 studies	63% ± 19%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	30% ± 10%	Explore
plasmacytoid dendritic cell	4 studies	27% ± 14%	Explore
hematopoietic precursor cell	4 studies	34% ± 11%	Explore
astrocyte	4 studies	19% ± 2%	Explore
lymphocyte	4 studies	38% ± 17%	Explore
adventitial cell	4 studies	23% ± 9%	Explore
inflammatory macrophage	4 studies	33% ± 13%	Explore
myoepithelial cell	4 studies	48% ± 12%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	44% ± 17%	Explore
plasma cell	3 studies	29% ± 12%	Explore
monocyte-derived dendritic cell	3 studies	46% ± 10%	Explore
neural crest cell	3 studies	20% ± 2%	Explore
glial cell	3 studies	27% ± 12%	Explore
common myeloid progenitor	3 studies	32% ± 7%	Explore
hematopoietic stem cell	3 studies	36% ± 27%	Explore
muscle cell	3 studies	75% ± 10%	Explore
pancreatic ductal cell	3 studies	49% ± 10%	Explore
melanocyte	3 studies	27% ± 8%	Explore
T-helper 17 cell	3 studies	30% ± 13%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	34% ± 7%	Explore
erythrocyte	3 studies	27% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	45% ± 10%	Explore
lung	17 studies	29% ± 11%	Explore
kidney	6 studies	26% ± 8%	Explore
intestine	5 studies	24% ± 7%	Explore
bone marrow	4 studies	33% ± 17%	Explore
uterus	4 studies	40% ± 8%	Explore
brain	3 studies	22% ± 4%	Explore
breast	3 studies	26% ± 2%	Explore
liver	3 studies	23% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	99%	502737.86	168 / 170	95%	515.62	438 / 459
lung	94%	138106.14	545 / 578	95%	429.96	1097 / 1155
prostate	89%	266503.26	219 / 245	96%	531.21	482 / 502
esophagus	83%	514531.35	1195 / 1445	96%	606.19	176 / 183
ovary	80%	120493.86	144 / 180	97%	343.73	415 / 430
bladder	95%	569599.62	20 / 21	81%	300.01	407 / 504
breast	72%	79199.10	330 / 459	95%	317.05	1062 / 1118
intestine	79%	500940.02	766 / 966	85%	246.19	448 / 527
skin	46%	73416.53	827 / 1809	99%	519.96	467 / 472
stomach	48%	229061.54	174 / 359	91%	425.46	260 / 286
thymus	20%	21724.77	133 / 653	95%	268.15	577 / 605
kidney	18%	18189.72	16 / 89	85%	258.41	768 / 901
ureter	0%	0	0 / 0	100%	134.33	1 / 1
blood vessel	100%	776668.90	1334 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	430.24	44 / 45
pancreas	1%	647.66	2 / 328	93%	379.85	166 / 178
eye	0%	0	0 / 0	91%	189.05	73 / 80
lymph node	0%	0	0 / 0	86%	233.28	25 / 29
adipose	80%	110012.34	960 / 1204	0%	0	0 / 0
brain	0%	345.57	8 / 2642	75%	159.90	530 / 705
adrenal gland	5%	3521.80	12 / 258	53%	81.60	123 / 230
spleen	37%	35333.29	89 / 241	0%	0	0 / 0
liver	1%	856.29	2 / 226	29%	76.59	116 / 406
peripheral blood	27%	30698.13	254 / 929	0%	0	0 / 0
heart	13%	12307.97	116 / 861	0%	0	0 / 0
muscle	2%	1957.95	14 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001974	Biological process	blood vessel remodeling
GO_0007195	Biological process	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO_0072659	Biological process	protein localization to plasma membrane
GO_0070527	Biological process	platelet aggregation
GO_0032233	Biological process	positive regulation of actin filament bundle assembly
GO_0043113	Biological process	receptor clustering
GO_0030036	Biological process	actin cytoskeleton organization
GO_2000179	Biological process	positive regulation of neural precursor cell proliferation
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0030334	Biological process	regulation of cell migration
GO_0050821	Biological process	protein stabilization
GO_0044319	Biological process	wound healing, spreading of cells
GO_0042789	Biological process	mRNA transcription by RNA polymerase II
GO_1900026	Biological process	positive regulation of substrate adhesion-dependent cell spreading
GO_0042177	Biological process	negative regulation of protein catabolic process
GO_0060271	Biological process	cilium assembly
GO_1901381	Biological process	positive regulation of potassium ion transmembrane transport
GO_0001525	Biological process	angiogenesis
GO_0042307	Biological process	positive regulation of protein import into nucleus
GO_2001046	Biological process	positive regulation of integrin-mediated signaling pathway
GO_1902396	Biological process	protein localization to bicellular tight junction
GO_0045216	Biological process	cell-cell junction organization
GO_0051220	Biological process	cytoplasmic sequestering of protein
GO_0048680	Biological process	positive regulation of axon regeneration
GO_0003007	Biological process	heart morphogenesis
GO_0016479	Biological process	negative regulation of transcription by RNA polymerase I
GO_2001224	Biological process	positive regulation of neuron migration
GO_0090042	Biological process	tubulin deacetylation
GO_0097368	Biological process	establishment of Sertoli cell barrier
GO_0043433	Biological process	negative regulation of DNA-binding transcription factor activity
GO_0090307	Biological process	mitotic spindle assembly
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0051764	Biological process	actin crosslink formation
GO_0021943	Biological process	formation of radial glial scaffolds
GO_0007597	Biological process	blood coagulation, intrinsic pathway
GO_0010572	Biological process	positive regulation of platelet activation
GO_0045022	Biological process	early endosome to late endosome transport
GO_1905031	Biological process	regulation of membrane repolarization during cardiac muscle cell action potential
GO_0050808	Biological process	synapse organization
GO_0001837	Biological process	epithelial to mesenchymal transition
GO_1905000	Biological process	regulation of membrane repolarization during atrial cardiac muscle cell action potential
GO_0045184	Biological process	establishment of protein localization
GO_0051209	Biological process	release of sequestered calcium ion into cytosol
GO_0034394	Biological process	protein localization to cell surface
GO_0035855	Biological process	megakaryocyte development
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0021987	Biological process	cerebral cortex development
GO_0071526	Biological process	semaphorin-plexin signaling pathway
GO_0098978	Cellular component	glutamatergic synapse
GO_0030018	Cellular component	Z disc
GO_0098794	Cellular component	postsynapse
GO_0005802	Cellular component	trans-Golgi network
GO_0005634	Cellular component	nucleus
GO_0005730	Cellular component	nucleolus
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0030863	Cellular component	cortical cytoskeleton
GO_0015629	Cellular component	actin cytoskeleton
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0043198	Cellular component	dendritic shaft
GO_0043204	Cellular component	perikaryon
GO_0005884	Cellular component	actin filament
GO_0005737	Cellular component	cytoplasm
GO_0044295	Cellular component	axonal growth cone
GO_0005903	Cellular component	brush border
GO_1990779	Cellular component	glycoprotein Ib-IX-V complex
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005925	Cellular component	focal adhesion
GO_0005911	Cellular component	cell-cell junction
GO_0005829	Cellular component	cytosol
GO_0097440	Cellular component	apical dendrite
GO_0032432	Cellular component	actin filament bundle
GO_0031523	Cellular component	Myb complex
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0051020	Molecular function	GTPase binding
GO_0001664	Molecular function	G protein-coupled receptor binding
GO_0005080	Molecular function	protein kinase C binding
GO_0019900	Molecular function	kinase binding
GO_0051015	Molecular function	actin filament binding
GO_0046332	Molecular function	SMAD binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0045296	Molecular function	cadherin binding
GO_0031267	Molecular function	small GTPase binding
GO_0034988	Molecular function	Fc-gamma receptor I complex binding
GO_0015459	Molecular function	potassium channel regulator activity

IV. Literature review

[source]

Gene name	FLNA
Protein name	Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) MLL/FLNA fusion protein Filamin A Filamin-A FLNA protein
Synonyms	fusion FLN1 FLN MLL
Description	FUNCTION: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons . .
Accessions	A6NDY9 A0A7I2V3E6 ENST00000422373.6 A0A087WWY3 A0A7S5A4Z7 ENST00000360319.9 [P21333-2] F8WE98 Q2VP91 ENST00000676696.1 ENST00000444578.1 ENST00000673639.2 ENST00000438732.2 Q60FE6 Q6NXF2 H0Y5C6 A0A075TSG1 A0A075TKX8 ENST00000369850.10 [P21333-1] Q60FE5 ENST00000369856.8 ENST00000415241.1 A0A7P0NMY4 A0A669KBC6 H0Y5F3 ENST00000610817.5 H7C2E7 P21333 ENST00000420627.5

FLNA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review