GAK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046907Biological processintracellular transport
GO_0072659Biological processprotein localization to plasma membrane
GO_0016191Biological processsynaptic vesicle uncoating
GO_0006898Biological processreceptor-mediated endocytosis
GO_1905443Biological processregulation of clathrin coat assembly
GO_0007029Biological processendoplasmic reticulum organization
GO_0072318Biological processclathrin coat disassembly
GO_0034067Biological processprotein localization to Golgi apparatus
GO_0007030Biological processGolgi organization
GO_0048268Biological processclathrin coat assembly
GO_0010977Biological processnegative regulation of neuron projection development
GO_0090160Biological processGolgi to lysosome transport
GO_0072583Biological processclathrin-dependent endocytosis
GO_0051085Biological processchaperone cofactor-dependent protein refolding
GO_0098793Cellular componentpresynapse
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031982Cellular componentvesicle
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0005524Molecular functionATP binding
GO_0030276Molecular functionclathrin binding
GO_0005515Molecular functionprotein binding
GO_0030332Molecular functioncyclin binding

IV. Literature review

[source]
Gene nameGAK
Protein nameCyclin-G-associated kinase (EC 2.7.11.1)
Cyclin G associated kinase
GAK protein
SynonymshCG_1982003
DescriptionFUNCTION: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 . May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly . .

AccessionsENST00000502656.5
ENST00000510799.1
D6RC24
D6RF16
ENST00000507580.5
H0Y8H5
ENST00000511229.5
ENST00000511163.5 [O14976-2]
ENST00000628912.1
D6RAW3
ENST00000511980.5
ENST00000314167.9 [O14976-1]
O14976
H0Y9M4
ENST00000505819.5
ENST00000512325.3
H0YA39
ENST00000504668.5
D6RAQ7
Q3B835
D6RE78