LIMK1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LIMK1 at tissue level.

III. Associated gene sets

GO_0045773Biological processpositive regulation of axon extension
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0007165Biological processsignal transduction
GO_0032233Biological processpositive regulation of actin filament bundle assembly
GO_0030036Biological processactin cytoskeleton organization
GO_0048675Biological processaxon extension
GO_0007266Biological processRho protein signal transduction
GO_0043149Biological processstress fiber assembly
GO_0006468Biological processprotein phosphorylation
GO_0051444Biological processnegative regulation of ubiquitin-protein transferase activity
GO_0007399Biological processnervous system development
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0098978Cellular componentglutamatergic synapse
GO_0005856Cellular componentcytoskeleton
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0098794Cellular componentpostsynapse
GO_0043005Cellular componentneuron projection
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0001673Cellular componentmale germ cell nucleus
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0031072Molecular functionheat shock protein binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLIMK1
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1)
Uncharacterized protein LIMK1
LIM domain kinase 1 (EC 2.7.11.1)
SynonymsLIMK
DescriptionFUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways . Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop . LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton . In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation . Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly . Stimulates axonal outgrowth and may be involved in brain development . .; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). .

AccessionsE9PC47
ENST00000538333.3 [P53667-4]
P53667
Q75MU0
Q75MU4
ENST00000336180.7 [P53667-1]
ENST00000435201.5 [P53667-3]
ENST00000418310.5