LPXN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	21 studies	24% ± 8%	Explore
regulatory T cell	20 studies	29% ± 11%	Explore
CD8-positive, alpha-beta T cell	19 studies	29% ± 11%	Explore
natural killer cell	18 studies	22% ± 5%	Explore
memory B cell	17 studies	21% ± 7%	Explore
macrophage	16 studies	23% ± 7%	Explore
B cell	15 studies	23% ± 6%	Explore
T cell	15 studies	23% ± 6%	Explore
conventional dendritic cell	14 studies	27% ± 13%	Explore
plasmacytoid dendritic cell	14 studies	32% ± 12%	Explore
gamma-delta T cell	12 studies	27% ± 9%	Explore
classical monocyte	11 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	25% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	21% ± 5%	Explore
mucosal invariant T cell	10 studies	24% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	30% ± 14%	Explore
mature NK T cell	9 studies	26% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	23% ± 7%	Explore
monocyte	9 studies	20% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	32% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	18% ± 2%	Explore
dendritic cell	8 studies	27% ± 13%	Explore
innate lymphoid cell	7 studies	26% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	33% ± 15%	Explore
naive B cell	6 studies	26% ± 5%	Explore
myeloid cell	6 studies	31% ± 9%	Explore
alveolar macrophage	5 studies	26% ± 7%	Explore
T follicular helper cell	5 studies	24% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	28% ± 14%	Explore
microglial cell	5 studies	26% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	19% ± 3%	Explore
leukocyte	4 studies	24% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	42% ± 11%	Explore
astrocyte	4 studies	23% ± 5%	Explore
oligodendrocyte	4 studies	17% ± 1%	Explore
plasmablast	3 studies	28% ± 13%	Explore
plasma cell	3 studies	35% ± 15%	Explore
immature B cell	3 studies	24% ± 5%	Explore
mononuclear phagocyte	3 studies	27% ± 5%	Explore
lymphocyte	3 studies	28% ± 8%	Explore
germinal center B cell	3 studies	36% ± 4%	Explore
exhausted T cell	3 studies	41% ± 12%	Explore
CD4-positive helper T cell	3 studies	21% ± 3%	Explore
GABAergic neuron	3 studies	27% ± 2%	Explore
glutamatergic neuron	3 studies	32% ± 6%	Explore
non-classical monocyte	3 studies	21% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 7%	Explore
T-helper 17 cell	3 studies	30% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	19% ± 3%	Explore
brain	4 studies	26% ± 4%	Explore
lymph node	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	1016.26	653 / 653	100%	35.50	603 / 605
prostate	100%	840.76	245 / 245	100%	23.94	500 / 502
breast	100%	754.55	458 / 459	99%	29.00	1107 / 1118
lung	100%	1811.90	578 / 578	98%	28.42	1136 / 1155
kidney	100%	727.18	89 / 89	98%	28.84	880 / 901
intestine	100%	1106.82	966 / 966	97%	21.19	513 / 527
skin	99%	1436.76	1783 / 1809	98%	53.39	463 / 472
brain	96%	480.33	2537 / 2642	100%	23.26	705 / 705
stomach	99%	554.99	356 / 359	97%	24.57	277 / 286
uterus	99%	721.31	169 / 170	95%	17.58	438 / 459
ovary	100%	826.26	180 / 180	95%	13.65	407 / 430
pancreas	96%	428.60	316 / 328	97%	26.15	172 / 178
bladder	100%	941.10	21 / 21	91%	21.61	458 / 504
liver	100%	543.38	225 / 226	89%	11.51	362 / 406
esophagus	92%	440.01	1333 / 1445	92%	15.53	168 / 183
adrenal gland	100%	727.48	257 / 258	80%	7.10	185 / 230
lymph node	0%	0	0 / 0	100%	252.44	29 / 29
peripheral blood	100%	5610.37	929 / 929	0%	0	0 / 0
spleen	100%	3816.62	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.56	45 / 45
ureter	0%	0	0 / 0	100%	15.26	1 / 1
adipose	100%	872.53	1201 / 1204	0%	0	0 / 0
blood vessel	99%	825.96	1327 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	93%	11.32	74 / 80
heart	75%	254.38	643 / 861	0%	0	0 / 0
muscle	39%	115.53	316 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0050859	Biological process	negative regulation of B cell receptor signaling pathway
GO_0007165	Biological process	signal transduction
GO_0007162	Biological process	negative regulation of cell adhesion
GO_0007155	Biological process	cell adhesion
GO_0065003	Biological process	protein-containing complex assembly
GO_0034446	Biological process	substrate adhesion-dependent cell spreading
GO_0043542	Biological process	endothelial cell migration
GO_0033628	Biological process	regulation of cell adhesion mediated by integrin
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0016607	Cellular component	nuclear speck
GO_0002102	Cellular component	podosome
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0042995	Cellular component	cell projection
GO_0005634	Cellular component	nucleus
GO_0003712	Molecular function	transcription coregulator activity
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LPXN
Protein name	Leupaxin
Synonyms	LDLP
Description	FUNCTION: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. . FUNCTION: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). .
Accessions	ENST00000528954.5 [O60711-2] E9PNX9 B7Z5P7 O60711 ENST00000528489.1 ENST00000395074.7 [O60711-1] ENST00000530561.5

LPXN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review