HSPA5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903894Biological processregulation of IRE1-mediated unfolded protein response
GO_0042149Biological processcellular response to glucose starvation
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0060904Biological processregulation of protein folding in endoplasmic reticulum
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_1903895Biological processnegative regulation of IRE1-mediated unfolded protein response
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0006983Biological processER overload response
GO_1903897Biological processregulation of PERK-mediated unfolded protein response
GO_0031204Biological processpost-translational protein targeting to membrane, translocation
GO_0071353Biological processcellular response to interleukin-4
GO_0021680Biological processcerebellar Purkinje cell layer development
GO_1903891Biological processregulation of ATF6-mediated unfolded protein response
GO_0021589Biological processcerebellum structural organization
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_0034975Biological processprotein folding in endoplasmic reticulum
GO_0042026Biological processprotein refolding
GO_0021762Biological processsubstantia nigra development
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0035437Biological processmaintenance of protein localization in endoplasmic reticulum
GO_0051085Biological processchaperone cofactor-dependent protein refolding
GO_0036503Biological processERAD pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005925Cellular componentfocal adhesion
GO_0009986Cellular componentcell surface
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0008180Cellular componentCOP9 signalosome
GO_0005737Cellular componentcytoplasm
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0034663Cellular componentendoplasmic reticulum chaperone complex
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0042470Cellular componentmelanosome
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0051787Molecular functionmisfolded protein binding
GO_0019904Molecular functionprotein domain specific binding
GO_0044183Molecular functionprotein folding chaperone
GO_0043022Molecular functionribosome binding
GO_0045296Molecular functioncadherin binding
GO_0031072Molecular functionheat shock protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0051082Molecular functionunfolded protein binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0140662Molecular functionATP-dependent protein folding chaperone
GO_0005524Molecular functionATP binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameHSPA5
Protein name78 kDa glucose-regulated protein (Binding-immunoglobulin protein) (Heat shock protein 70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
SynonymsGRP78
DescriptionFUNCTION: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen . Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) . In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation . .; FUNCTION: (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus . Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells . .; FUNCTION: (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi . Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression . .

AccessionsENST00000680272.1
A0A7P0TAI0
P11021
ENST00000680032.1
ENST00000324460.7
A0A7P0TB36