CFL1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	48 studies	73% ± 22%	Explore
natural killer cell	46 studies	83% ± 19%	Explore
macrophage	45 studies	75% ± 25%	Explore
endothelial cell	45 studies	67% ± 25%	Explore
T cell	42 studies	73% ± 26%	Explore
CD8-positive, alpha-beta T cell	40 studies	80% ± 19%	Explore
fibroblast	39 studies	68% ± 22%	Explore
CD4-positive, alpha-beta T cell	34 studies	80% ± 20%	Explore
pericyte	33 studies	74% ± 24%	Explore
conventional dendritic cell	31 studies	91% ± 11%	Explore
dendritic cell	30 studies	82% ± 19%	Explore
classical monocyte	29 studies	85% ± 17%	Explore
smooth muscle cell	28 studies	74% ± 24%	Explore
plasmacytoid dendritic cell	28 studies	88% ± 15%	Explore
regulatory T cell	28 studies	87% ± 13%	Explore
monocyte	27 studies	76% ± 25%	Explore
non-classical monocyte	25 studies	91% ± 13%	Explore
epithelial cell	24 studies	78% ± 20%	Explore
plasma cell	23 studies	61% ± 22%	Explore
endothelial cell of lymphatic vessel	23 studies	77% ± 22%	Explore
mature NK T cell	22 studies	80% ± 20%	Explore
mast cell	21 studies	64% ± 21%	Explore
gamma-delta T cell	21 studies	80% ± 22%	Explore
basal cell	21 studies	75% ± 20%	Explore
memory B cell	20 studies	87% ± 9%	Explore
naive B cell	19 studies	79% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	77% ± 16%	Explore
connective tissue cell	19 studies	74% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	81% ± 23%	Explore
mucosal invariant T cell	16 studies	83% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	91% ± 10%	Explore
ciliated cell	16 studies	56% ± 21%	Explore
neutrophil	16 studies	63% ± 25%	Explore
capillary endothelial cell	16 studies	67% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	84% ± 20%	Explore
myofibroblast cell	15 studies	79% ± 21%	Explore
myeloid cell	15 studies	77% ± 27%	Explore
endothelial cell of artery	14 studies	73% ± 18%	Explore
astrocyte	14 studies	36% ± 20%	Explore
vein endothelial cell	14 studies	69% ± 24%	Explore
innate lymphoid cell	13 studies	82% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	79% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	83% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	79% ± 22%	Explore
plasmablast	12 studies	78% ± 21%	Explore
secretory cell	12 studies	79% ± 15%	Explore
endothelial cell of vascular tree	12 studies	80% ± 22%	Explore
platelet	11 studies	69% ± 26%	Explore
microglial cell	11 studies	52% ± 31%	Explore
type I pneumocyte	10 studies	67% ± 21%	Explore
T follicular helper cell	10 studies	84% ± 9%	Explore
leukocyte	10 studies	77% ± 19%	Explore
glutamatergic neuron	10 studies	45% ± 15%	Explore
progenitor cell	10 studies	90% ± 10%	Explore
abnormal cell	10 studies	72% ± 25%	Explore
goblet cell	10 studies	80% ± 16%	Explore
mesothelial cell	10 studies	73% ± 22%	Explore
oligodendrocyte	10 studies	32% ± 13%	Explore
type II pneumocyte	9 studies	63% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	87% ± 14%	Explore
enterocyte	9 studies	72% ± 29%	Explore
oligodendrocyte precursor cell	9 studies	43% ± 28%	Explore
club cell	8 studies	70% ± 22%	Explore
IgG plasma cell	8 studies	42% ± 18%	Explore
hematopoietic stem cell	8 studies	89% ± 11%	Explore
neuron	8 studies	68% ± 23%	Explore
erythrocyte	8 studies	65% ± 20%	Explore
alveolar macrophage	7 studies	73% ± 27%	Explore
ionocyte	7 studies	70% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	80% ± 26%	Explore
mononuclear phagocyte	7 studies	77% ± 22%	Explore
epithelial cell of proximal tubule	7 studies	63% ± 16%	Explore
IgA plasma cell	7 studies	40% ± 19%	Explore
GABAergic neuron	7 studies	33% ± 14%	Explore
amacrine cell	7 studies	52% ± 28%	Explore
precursor B cell	7 studies	82% ± 27%	Explore
interneuron	7 studies	48% ± 23%	Explore
hematopoietic precursor cell	6 studies	76% ± 23%	Explore
respiratory goblet cell	6 studies	64% ± 20%	Explore
kidney loop of Henle epithelial cell	6 studies	64% ± 9%	Explore
renal alpha-intercalated cell	6 studies	86% ± 7%	Explore
megakaryocyte	6 studies	78% ± 23%	Explore
brush cell	6 studies	73% ± 20%	Explore
glial cell	6 studies	56% ± 24%	Explore
immature B cell	6 studies	94% ± 4%	Explore
intermediate monocyte	6 studies	90% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	88% ± 7%	Explore
CD4-positive helper T cell	5 studies	76% ± 11%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	80% ± 23%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	87% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	87% ± 7%	Explore
exhausted T cell	5 studies	94% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	77% ± 19%	Explore
enteroendocrine cell	5 studies	88% ± 10%	Explore
erythroblast	5 studies	70% ± 24%	Explore
transit amplifying cell	5 studies	80% ± 20%	Explore
OFF-bipolar cell	5 studies	49% ± 30%	Explore
ON-bipolar cell	5 studies	48% ± 30%	Explore
retinal ganglion cell	5 studies	75% ± 30%	Explore
retinal cone cell	5 studies	51% ± 27%	Explore
retinal rod cell	5 studies	38% ± 19%	Explore
lymphocyte	5 studies	78% ± 31%	Explore
neuroendocrine cell	5 studies	85% ± 14%	Explore
T-helper 17 cell	5 studies	91% ± 8%	Explore
group 3 innate lymphoid cell	5 studies	91% ± 6%	Explore
retina horizontal cell	5 studies	60% ± 25%	Explore
double negative thymocyte	5 studies	94% ± 4%	Explore
granulocyte	5 studies	80% ± 11%	Explore
deuterosomal cell	4 studies	44% ± 12%	Explore
duct epithelial cell	4 studies	73% ± 1%	Explore
precursor cell	4 studies	74% ± 32%	Explore
squamous epithelial cell	4 studies	56% ± 24%	Explore
pancreatic A cell	4 studies	91% ± 7%	Explore
type B pancreatic cell	4 studies	80% ± 13%	Explore
glomerular endothelial cell	4 studies	69% ± 14%	Explore
podocyte	4 studies	83% ± 10%	Explore
intestinal crypt stem cell	4 studies	92% ± 6%	Explore
retinal bipolar neuron	4 studies	55% ± 31%	Explore
GABAergic amacrine cell	4 studies	52% ± 20%	Explore
glycinergic amacrine cell	4 studies	40% ± 18%	Explore
pro-B cell	4 studies	92% ± 4%	Explore
adventitial cell	4 studies	68% ± 14%	Explore
mucus secreting cell	4 studies	67% ± 17%	Explore
Mueller cell	4 studies	54% ± 23%	Explore
inflammatory macrophage	4 studies	72% ± 15%	Explore
acinar cell	4 studies	50% ± 26%	Explore
muscle cell	4 studies	52% ± 24%	Explore
germinal center B cell	4 studies	93% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	91% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	61% ± 20%	Explore
hepatocyte	4 studies	47% ± 21%	Explore
melanocyte	4 studies	75% ± 17%	Explore
T-helper 1 cell	4 studies	94% ± 5%	Explore
pancreatic D cell	3 studies	84% ± 15%	Explore
monocyte-derived dendritic cell	3 studies	92% ± 11%	Explore
renal beta-intercalated cell	3 studies	91% ± 4%	Explore
neural crest cell	3 studies	90% ± 11%	Explore
renal principal cell	3 studies	77% ± 7%	Explore
thymocyte	3 studies	76% ± 16%	Explore
extravillous trophoblast	3 studies	87% ± 8%	Explore
placental villous trophoblast	3 studies	95% ± 3%	Explore
retinal pigment epithelial cell	3 studies	58% ± 26%	Explore
serous secreting cell	3 studies	55% ± 9%	Explore
tissue-resident macrophage	3 studies	71% ± 29%	Explore
follicular B cell	3 studies	71% ± 10%	Explore
intraepithelial lymphocyte	3 studies	94% ± 3%	Explore
rod bipolar cell	3 studies	56% ± 21%	Explore
myoepithelial cell	3 studies	88% ± 4%	Explore
IgM plasma cell	3 studies	62% ± 18%	Explore
pancreatic ductal cell	3 studies	93% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	98% ± 3%	Explore
keratinocyte	3 studies	83% ± 12%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	92% ± 3%	Explore
double-positive, alpha-beta thymocyte	3 studies	95% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	90% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	83% ± 15%	Explore
lung	19 studies	73% ± 18%	Explore
brain	16 studies	45% ± 20%	Explore
intestine	14 studies	66% ± 24%	Explore
kidney	9 studies	72% ± 19%	Explore
eye	9 studies	54% ± 21%	Explore
liver	8 studies	55% ± 26%	Explore
lymph node	7 studies	83% ± 9%	Explore
bone marrow	6 studies	71% ± 24%	Explore
uterus	6 studies	70% ± 28%	Explore
pancreas	5 studies	73% ± 23%	Explore
prostate	5 studies	62% ± 32%	Explore
placenta	4 studies	75% ± 25%	Explore
heart	4 studies	35% ± 17%	Explore
breast	4 studies	85% ± 7%	Explore
ovary	3 studies	49% ± 15%	Explore
adipose	3 studies	42% ± 29%	Explore
adrenal gland	3 studies	73% ± 19%	Explore
esophagus	3 studies	71% ± 13%	Explore
skin	3 studies	72% ± 13%	Explore
stomach	3 studies	44% ± 22%	Explore
thymus	3 studies	81% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	29093.09	1445 / 1445	100%	378.33	183 / 183
intestine	100%	38068.26	966 / 966	100%	528.84	527 / 527
ovary	100%	16696.26	180 / 180	100%	489.75	430 / 430
skin	100%	35002.82	1809 / 1809	100%	452.44	472 / 472
uterus	100%	29840.95	170 / 170	100%	450.78	459 / 459
brain	100%	30914.80	2640 / 2642	100%	412.56	705 / 705
thymus	100%	20416.45	652 / 653	100%	299.54	604 / 605
stomach	100%	22530.96	359 / 359	100%	499.39	285 / 286
bladder	100%	26374.38	21 / 21	100%	506.82	502 / 504
kidney	100%	26326.39	89 / 89	99%	224.62	896 / 901
prostate	100%	23908.58	244 / 245	100%	308.64	501 / 502
breast	100%	26685.64	459 / 459	99%	408.27	1110 / 1118
lung	100%	35009.32	577 / 578	99%	385.27	1147 / 1155
adrenal gland	100%	21551.24	258 / 258	96%	213.60	221 / 230
liver	96%	13172.57	216 / 226	100%	206.19	405 / 406
pancreas	78%	7196.66	256 / 328	99%	425.16	177 / 178
adipose	100%	28633.64	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	342.20	80 / 80
lymph node	0%	0	0 / 0	100%	677.28	29 / 29
spleen	100%	39028.28	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	433.14	45 / 45
ureter	0%	0	0 / 0	100%	1115.81	1 / 1
blood vessel	100%	35432.55	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	63653.36	926 / 929	0%	0	0 / 0
heart	97%	15886.19	836 / 861	0%	0	0 / 0
muscle	75%	6429.40	601 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030042	Biological process	actin filament depolymerization
GO_0022604	Biological process	regulation of cell morphogenesis
GO_0009615	Biological process	response to virus
GO_0000281	Biological process	mitotic cytokinesis
GO_0007010	Biological process	cytoskeleton organization
GO_0044794	Biological process	positive regulation by host of viral process
GO_0051293	Biological process	establishment of spindle localization
GO_0040019	Biological process	positive regulation of embryonic development
GO_0051014	Biological process	actin filament severing
GO_0030036	Biological process	actin cytoskeleton organization
GO_0061001	Biological process	regulation of dendritic spine morphogenesis
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0030043	Biological process	actin filament fragmentation
GO_0007266	Biological process	Rho protein signal transduction
GO_0032587	Cellular component	ruffle membrane
GO_0005615	Cellular component	extracellular space
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0016363	Cellular component	nuclear matrix
GO_0015629	Cellular component	actin cytoskeleton
GO_0031258	Cellular component	lamellipodium membrane
GO_0005829	Cellular component	cytosol
GO_0030426	Cellular component	growth cone
GO_0005737	Cellular component	cytoplasm
GO_0030027	Cellular component	lamellipodium
GO_0031982	Cellular component	vesicle
GO_0005634	Cellular component	nucleus
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CFL1
Protein name	Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform) Cofilin-1 (Cofilin, non-muscle isoform)
Synonyms	hCG_2039457 CFL
Description	FUNCTION: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity . In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics . Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells . Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation . Required for neural tube morphogenesis and neural crest cell migration (By similarity). .
Accessions	ENST00000308162.10 ENST00000534769.5 E9PQB7 E9PS23 ENST00000524553.5 ENST00000527344.5 E9PK25 E9PLJ3 ENST00000532134.5 ENST00000530413.1 G3V1A4 ENST00000525451.6 E9PP50 ENST00000526975.1 ENST00000531407.5 P23528 ENST00000531413.5 ENST00000534784.1

CFL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review