SLC9A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035994Biological processresponse to muscle stretch
GO_0030011Biological processmaintenance of cell polarity
GO_0010882Biological processregulation of cardiac muscle contraction by calcium ion signaling
GO_0071236Biological processcellular response to antibiotic
GO_0071260Biological processcellular response to mechanical stimulus
GO_0086092Biological processregulation of the force of heart contraction by cardiac conduction
GO_0032869Biological processcellular response to insulin stimulus
GO_0030307Biological processpositive regulation of cell growth
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0055007Biological processcardiac muscle cell differentiation
GO_0070886Biological processpositive regulation of calcineurin-NFAT signaling cascade
GO_0006811Biological processmonoatomic ion transport
GO_0071456Biological processcellular response to hypoxia
GO_0071872Biological processcellular response to epinephrine stimulus
GO_0006885Biological processregulation of pH
GO_0006883Biological processintracellular sodium ion homeostasis
GO_0086003Biological processcardiac muscle cell contraction
GO_0071468Biological processcellular response to acidic pH
GO_0071805Biological processpotassium ion transmembrane transport
GO_0010447Biological processresponse to acidic pH
GO_0070417Biological processcellular response to cold
GO_0051259Biological processprotein complex oligomerization
GO_0045760Biological processpositive regulation of action potential
GO_0043066Biological processnegative regulation of apoptotic process
GO_0051492Biological processregulation of stress fiber assembly
GO_0098719Biological processsodium ion import across plasma membrane
GO_0035794Biological processpositive regulation of mitochondrial membrane permeability
GO_0051893Biological processregulation of focal adhesion assembly
GO_0071257Biological processcellular response to electrical stimulus
GO_1903281Biological processpositive regulation of calcium:sodium antiporter activity
GO_0051453Biological processregulation of intracellular pH
GO_0086036Biological processregulation of cardiac muscle cell membrane potential
GO_0048863Biological processstem cell differentiation
GO_0098735Biological processpositive regulation of the force of heart contraction
GO_0043065Biological processpositive regulation of apoptotic process
GO_0071407Biological processcellular response to organic cyclic compound
GO_0016477Biological processcell migration
GO_1902600Biological processproton transmembrane transport
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0036376Biological processsodium ion export across plasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005925Cellular componentfocal adhesion
GO_0009986Cellular componentcell surface
GO_0030315Cellular componentT-tubule
GO_0005737Cellular componentcytoplasm
GO_0090533Cellular componentcation-transporting ATPase complex
GO_0030027Cellular componentlamellipodium
GO_0014704Cellular componentintercalated disc
GO_0060090Molecular functionmolecular adaptor activity
GO_0005543Molecular functionphospholipid binding
GO_0015385Molecular functionsodium:proton antiporter activity
GO_0015386Molecular functionpotassium:proton antiporter activity
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0042802Molecular functionidentical protein binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding
GO_0086040Molecular functionsodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
GO_0030346Molecular functionprotein phosphatase 2B binding

IV. Literature review

[source]
Gene nameSLC9A1
Protein nameSodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)
Solute carrier family 9 member A1
SynonymsNHE1
APNH1
DescriptionFUNCTION: Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism . Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival . In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter . SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs . .

AccessionsENST00000374084.2
B1ALD5
ENST00000263980.8 [P19634-1]
P19634
ENST00000374086.3 [P19634-2]