Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 2211.59 | 180 / 180 | 100% | 21.52 | 430 / 430 |
| uterus | 100% | 3655.22 | 170 / 170 | 100% | 30.32 | 459 / 459 |
| skin | 100% | 3186.91 | 1808 / 1809 | 100% | 36.92 | 472 / 472 |
| esophagus | 100% | 3117.70 | 1444 / 1445 | 100% | 16.67 | 183 / 183 |
| kidney | 100% | 3254.45 | 89 / 89 | 100% | 20.82 | 900 / 901 |
| thymus | 100% | 2589.53 | 653 / 653 | 100% | 23.89 | 604 / 605 |
| lung | 100% | 2531.44 | 577 / 578 | 100% | 22.08 | 1155 / 1155 |
| brain | 100% | 4250.83 | 2637 / 2642 | 100% | 25.88 | 705 / 705 |
| intestine | 100% | 3135.77 | 964 / 966 | 100% | 19.20 | 526 / 527 |
| bladder | 100% | 3342.90 | 21 / 21 | 100% | 24.27 | 502 / 504 |
| breast | 100% | 5818.78 | 459 / 459 | 100% | 22.42 | 1113 / 1118 |
| prostate | 100% | 2289.47 | 244 / 245 | 100% | 16.20 | 500 / 502 |
| adrenal gland | 100% | 2499.80 | 258 / 258 | 99% | 22.03 | 227 / 230 |
| stomach | 97% | 1988.10 | 350 / 359 | 100% | 17.14 | 285 / 286 |
| liver | 63% | 600.31 | 142 / 226 | 99% | 12.58 | 400 / 406 |
| pancreas | 54% | 504.89 | 178 / 328 | 99% | 21.43 | 177 / 178 |
| adipose | 100% | 7328.61 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 43.30 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 24.67 | 29 / 29 |
| spleen | 100% | 1753.00 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 20.70 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 16.89 | 1 / 1 |
| blood vessel | 100% | 3395.42 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 2618.15 | 848 / 861 | 0% | 0 | 0 / 0 |
| muscle | 97% | 1584.38 | 776 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 69% | 1142.94 | 644 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0090051 | Biological process | negative regulation of cell migration involved in sprouting angiogenesis |
| GO_0051781 | Biological process | positive regulation of cell division |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0006469 | Biological process | negative regulation of protein kinase activity |
| GO_0072659 | Biological process | protein localization to plasma membrane |
| GO_0032148 | Biological process | activation of protein kinase B activity |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0051496 | Biological process | positive regulation of stress fiber assembly |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0006933 | Biological process | negative regulation of cell adhesion involved in substrate-bound cell migration |
| GO_2001044 | Biological process | regulation of integrin-mediated signaling pathway |
| GO_0010595 | Biological process | positive regulation of endothelial cell migration |
| GO_0070373 | Biological process | negative regulation of ERK1 and ERK2 cascade |
| GO_0051895 | Biological process | negative regulation of focal adhesion assembly |
| GO_0035148 | Biological process | tube formation |
| GO_0010764 | Biological process | negative regulation of fibroblast migration |
| GO_0097746 | Biological process | blood vessel diameter maintenance |
| GO_0043113 | Biological process | receptor clustering |
| GO_0002043 | Biological process | blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0043087 | Biological process | regulation of GTPase activity |
| GO_0031214 | Biological process | biomineral tissue development |
| GO_0030154 | Biological process | cell differentiation |
| GO_0033628 | Biological process | regulation of cell adhesion mediated by integrin |
| GO_0090315 | Biological process | negative regulation of protein targeting to membrane |
| GO_0051894 | Biological process | positive regulation of focal adhesion assembly |
| GO_0090314 | Biological process | positive regulation of protein targeting to membrane |
| GO_1900025 | Biological process | negative regulation of substrate adhesion-dependent cell spreading |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0045747 | Biological process | positive regulation of Notch signaling pathway |
| GO_0051451 | Biological process | myoblast migration |
| GO_0032091 | Biological process | negative regulation of protein binding |
| GO_0033622 | Biological process | integrin activation |
| GO_0035924 | Biological process | cellular response to vascular endothelial growth factor stimulus |
| GO_0044344 | Biological process | cellular response to fibroblast growth factor stimulus |
| GO_0016477 | Biological process | cell migration |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0001726 | Cellular component | ruffle |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0034451 | Cellular component | centriolar satellite |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005829 | Cellular component | cytosol |
| GO_0071944 | Cellular component | cell periphery |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0005634 | Cellular component | nucleus |
| GO_0005092 | Molecular function | GDP-dissociation inhibitor activity |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0005178 | Molecular function | integrin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ITGB1BP1 |
| Protein name | Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1) ITGB1BP1 protein Integrin beta 1 binding protein 1, isoform CRA_a (Integrin subunit beta 1 binding protein 1) Integrin subunit beta 1 binding protein 1 Integrin beta 1 binding protein 1, isoform CRA_g (Integrin subunit beta 1 binding protein 1) |
| Synonyms | hCG_1686416 ICAP1 |
| Description | FUNCTION: Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. . |
| Accessions | ENST00000360635.7 [O14713-1] C9IZZ8 ENST00000464228.5 C9J5T5 ENST00000456913.6 Q6IAZ8 ENST00000238091.8 [O14713-2] C9J0J6 ENST00000483795.5 O14713 ENST00000359712.7 ENST00000492079.5 ENST00000460001.5 C9JBU8 C9JZ07 G3V1A3 F8WF20 ENST00000497105.1 ENST00000494563.5 ENST00000467606.5 A8MPU2 ENST00000484735.5 ENST00000488451.5 [O14713-2] C9J6Y2 ENST00000355346.9 [O14713-1] |
