RALA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0007265Biological processRas protein signal transduction
GO_0031623Biological processreceptor internalization
GO_0090141Biological processpositive regulation of mitochondrial fission
GO_0051665Biological processmembrane raft localization
GO_0007165Biological processsignal transduction
GO_0017157Biological processregulation of exocytosis
GO_0051301Biological processcell division
GO_0006935Biological processchemotaxis
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0051491Biological processpositive regulation of filopodium assembly
GO_0006887Biological processexocytosis
GO_0072655Biological processestablishment of protein localization to mitochondrion
GO_0099149Biological processregulation of postsynaptic neurotransmitter receptor internalization
GO_0001843Biological processneural tube closure
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005886Cellular componentplasma membrane
GO_0030139Cellular componentendocytic vesicle
GO_0005739Cellular componentmitochondrion
GO_0097060Cellular componentsynaptic membrane
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0090543Cellular componentFlemming body
GO_0009986Cellular componentcell surface
GO_0032154Cellular componentcleavage furrow
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0019003Molecular functionGDP binding
GO_0017022Molecular functionmyosin binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003925Molecular functionG protein activity
GO_0005525Molecular functionGTP binding
GO_0031755Molecular functionEdg-2 lysophosphatidic acid receptor binding
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRALA
Protein nameRAS like proto-oncogene A
Ras-related protein Ral-A (EC 3.6.5.2)
SynonymsRAL
DescriptionFUNCTION: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors . Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling . Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells . During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody . During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 . .

AccessionsP11233
ENST00000005257.7
C9JPE8
ENST00000436179.1
ENST00000434466.1
H7C3P7