Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 20 studies | 68% ± 15% | |
| lung | 19 studies | 60% ± 16% | |
| intestine | 12 studies | 46% ± 19% | |
| brain | 11 studies | 38% ± 13% | |
| kidney | 9 studies | 54% ± 19% | |
| eye | 8 studies | 33% ± 14% | |
| liver | 7 studies | 44% ± 18% | |
| lymph node | 6 studies | 57% ± 24% | |
| bone marrow | 6 studies | 48% ± 24% | |
| pancreas | 5 studies | 65% ± 26% | |
| heart | 5 studies | 28% ± 10% | |
| uterus | 5 studies | 61% ± 16% | |
| adipose | 5 studies | 35% ± 21% | |
| prostate | 5 studies | 34% ± 13% | |
| placenta | 4 studies | 70% ± 18% | |
| esophagus | 4 studies | 48% ± 27% | |
| breast | 4 studies | 60% ± 7% | |
| adrenal gland | 3 studies | 56% ± 11% | |
| skin | 3 studies | 45% ± 15% | |
| thymus | 3 studies | 67% ± 25% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 28351.92 | 1445 / 1445 | 100% | 255.03 | 183 / 183 |
| intestine | 100% | 25697.42 | 966 / 966 | 100% | 357.65 | 527 / 527 |
| lung | 100% | 35230.40 | 578 / 578 | 100% | 325.37 | 1155 / 1155 |
| ovary | 100% | 25691.18 | 180 / 180 | 100% | 341.14 | 430 / 430 |
| stomach | 100% | 19519.56 | 359 / 359 | 100% | 330.13 | 286 / 286 |
| skin | 100% | 28559.32 | 1808 / 1809 | 100% | 405.63 | 472 / 472 |
| breast | 100% | 33741.47 | 459 / 459 | 100% | 432.89 | 1117 / 1118 |
| thymus | 100% | 26666.43 | 653 / 653 | 100% | 407.02 | 604 / 605 |
| bladder | 100% | 27876.24 | 21 / 21 | 100% | 347.51 | 503 / 504 |
| uterus | 100% | 26886.26 | 170 / 170 | 100% | 333.54 | 458 / 459 |
| prostate | 100% | 19598.07 | 244 / 245 | 100% | 282.21 | 502 / 502 |
| kidney | 100% | 22414.92 | 89 / 89 | 100% | 293.21 | 897 / 901 |
| brain | 99% | 13789.79 | 2627 / 2642 | 100% | 371.12 | 705 / 705 |
| adrenal gland | 100% | 27472.17 | 258 / 258 | 98% | 219.48 | 225 / 230 |
| pancreas | 95% | 9959.24 | 313 / 328 | 100% | 368.17 | 178 / 178 |
| liver | 89% | 8001.41 | 201 / 226 | 99% | 184.71 | 403 / 406 |
| adipose | 100% | 38235.36 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 45648.70 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 210.40 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 486.17 | 29 / 29 |
| spleen | 100% | 25794.63 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 310.22 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 178.03 | 1 / 1 |
| peripheral blood | 100% | 40505.42 | 926 / 929 | 0% | 0 | 0 / 0 |
| muscle | 100% | 17367.30 | 800 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 15629.68 | 847 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045198 | Biological process | establishment of epithelial cell apical/basal polarity |
| GO_1901224 | Biological process | positive regulation of non-canonical NF-kappaB signal transduction |
| GO_0042476 | Biological process | odontogenesis |
| GO_0060193 | Biological process | positive regulation of lipase activity |
| GO_0002363 | Biological process | alpha-beta T cell lineage commitment |
| GO_0001764 | Biological process | neuron migration |
| GO_0090324 | Biological process | negative regulation of oxidative phosphorylation |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0030334 | Biological process | regulation of cell migration |
| GO_0044319 | Biological process | wound healing, spreading of cells |
| GO_0003189 | Biological process | aortic valve formation |
| GO_2000672 | Biological process | negative regulation of motor neuron apoptotic process |
| GO_1904996 | Biological process | positive regulation of leukocyte adhesion to vascular endothelial cell |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0045792 | Biological process | negative regulation of cell size |
| GO_0043931 | Biological process | ossification involved in bone maturation |
| GO_0032467 | Biological process | positive regulation of cytokinesis |
| GO_0007519 | Biological process | skeletal muscle tissue development |
| GO_0031122 | Biological process | cytoplasmic microtubule organization |
| GO_1902766 | Biological process | skeletal muscle satellite cell migration |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_1905274 | Biological process | regulation of modification of postsynaptic actin cytoskeleton |
| GO_0001822 | Biological process | kidney development |
| GO_0021795 | Biological process | cerebral cortex cell migration |
| GO_1903427 | Biological process | negative regulation of reactive oxygen species biosynthetic process |
| GO_0043366 | Biological process | beta selection |
| GO_0071345 | Biological process | cellular response to cytokine stimulus |
| GO_0034446 | Biological process | substrate adhesion-dependent cell spreading |
| GO_0043542 | Biological process | endothelial cell migration |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_1990869 | Biological process | cellular response to chemokine |
| GO_0010975 | Biological process | regulation of neuron projection development |
| GO_1903673 | Biological process | mitotic cleavage furrow formation |
| GO_0070507 | Biological process | regulation of microtubule cytoskeleton organization |
| GO_0030521 | Biological process | androgen receptor signaling pathway |
| GO_2000406 | Biological process | positive regulation of T cell migration |
| GO_0046638 | Biological process | positive regulation of alpha-beta T cell differentiation |
| GO_0099159 | Biological process | regulation of modification of postsynaptic structure |
| GO_0010812 | Biological process | negative regulation of cell-substrate adhesion |
| GO_0033144 | Biological process | negative regulation of intracellular steroid hormone receptor signaling pathway |
| GO_0071803 | Biological process | positive regulation of podosome assembly |
| GO_0090051 | Biological process | negative regulation of cell migration involved in sprouting angiogenesis |
| GO_0061430 | Biological process | bone trabecula morphogenesis |
| GO_0003100 | Biological process | regulation of systemic arterial blood pressure by endothelin |
| GO_0035385 | Biological process | Roundabout signaling pathway |
| GO_0051496 | Biological process | positive regulation of stress fiber assembly |
| GO_0050919 | Biological process | negative chemotaxis |
| GO_0021861 | Biological process | forebrain radial glial cell differentiation |
| GO_0090307 | Biological process | mitotic spindle assembly |
| GO_0051893 | Biological process | regulation of focal adhesion assembly |
| GO_0097498 | Biological process | endothelial tube lumen extension |
| GO_0036089 | Biological process | cleavage furrow formation |
| GO_0016477 | Biological process | cell migration |
| GO_2000177 | Biological process | regulation of neural precursor cell proliferation |
| GO_0043297 | Biological process | apical junction assembly |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0033688 | Biological process | regulation of osteoblast proliferation |
| GO_1904695 | Biological process | positive regulation of vascular associated smooth muscle contraction |
| GO_0038027 | Biological process | apolipoprotein A-I-mediated signaling pathway |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0034329 | Biological process | cell junction assembly |
| GO_0021762 | Biological process | substantia nigra development |
| GO_0097049 | Biological process | motor neuron apoptotic process |
| GO_0007266 | Biological process | Rho protein signal transduction |
| GO_0043149 | Biological process | stress fiber assembly |
| GO_0001998 | Biological process | angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure |
| GO_0060071 | Biological process | Wnt signaling pathway, planar cell polarity pathway |
| GO_0071526 | Biological process | semaphorin-plexin signaling pathway |
| GO_0045666 | Biological process | positive regulation of neuron differentiation |
| GO_0071902 | Biological process | positive regulation of protein serine/threonine kinase activity |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0098794 | Cellular component | postsynapse |
| GO_0043296 | Cellular component | apical junction complex |
| GO_0071944 | Cellular component | cell periphery |
| GO_0101003 | Cellular component | ficolin-1-rich granule membrane |
| GO_0005768 | Cellular component | endosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0030496 | Cellular component | midbody |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
| GO_0032587 | Cellular component | ruffle membrane |
| GO_0030667 | Cellular component | secretory granule membrane |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005829 | Cellular component | cytosol |
| GO_0005938 | Cellular component | cell cortex |
| GO_0030054 | Cellular component | cell junction |
| GO_0032154 | Cellular component | cleavage furrow |
| GO_0031982 | Cellular component | vesicle |
| GO_0017022 | Molecular function | myosin binding |
| GO_0003924 | Molecular function | GTPase activity |
| GO_0005525 | Molecular function | GTP binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0003925 | Molecular function | G protein activity |
| Gene name | RHOA |
| Protein name | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) Transforming protein RhoA Ras homolog family member A |
| Synonyms | hCG_20136 ARHA ARH12 RHO12 |
| Description | FUNCTION: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle . Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers . Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis . Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion . Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly . The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization . Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis . Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center . May be an activator of PLCE1 . In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). .; FUNCTION: (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague. . |
| Accessions | P61586 C9JNR4 ENST00000677684.1 ENST00000445425 ENST00000676712.2 A0A7I2V5E6 A0A7I2V3G1 ENST00000678200.1 ENST00000454011.7 A0A0B6XK12 A0A7I2YQV1 ENST00000445425.6 ENST00000418115.6 ENST00000678921.2 C9JX21 ENST00000679208.1 ENST00000422781.6 C9JRM1 A0A024R324 |
