PIP5K1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0030216Biological processkeratinocyte differentiation
GO_0006650Biological processglycerophospholipid metabolic process
GO_0072659Biological processprotein localization to plasma membrane
GO_0090630Biological processactivation of GTPase activity
GO_0007165Biological processsignal transduction
GO_0010761Biological processfibroblast migration
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0097178Biological processruffle assembly
GO_0030036Biological processactin cytoskeleton organization
GO_0008654Biological processphospholipid biosynthetic process
GO_0006909Biological processphagocytosis
GO_0048041Biological processfocal adhesion assembly
GO_0016477Biological processcell migration
GO_0060326Biological processcell chemotaxis
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0032587Cellular componentruffle membrane
GO_0005886Cellular componentplasma membrane
GO_0016607Cellular componentnuclear speck
GO_0005847Cellular componentmRNA cleavage and polyadenylation specificity factor complex
GO_0005654Cellular componentnucleoplasm
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0052742Molecular functionphosphatidylinositol kinase activity
GO_0016308Molecular function1-phosphatidylinositol-4-phosphate 5-kinase activity
GO_0019900Molecular functionkinase binding
GO_0000285Molecular function1-phosphatidylinositol-3-phosphate 5-kinase activity
GO_0052810Molecular function1-phosphatidylinositol-5-kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePIP5K1A
Protein namePhosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)
Synonyms
DescriptionFUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility . PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) . PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro . Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation . Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane . Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs . .

AccessionsE9PSF8
ENST00000349792.9 [Q99755-3]
ENST00000418435.1
ENST00000424999.1
ENST00000454769.2
A6PW57
Q99755
A6PW56
A6PW58
ENST00000441902.6 [Q99755-4]
ENST00000409426.5
A2A5X0
ENST00000447555.5
ENST00000368890.8 [Q99755-2]
ENST00000368888.9 [Q99755-1]