Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 28% ± 13% | |
astrocyte | 12 studies | 30% ± 13% | |
microglial cell | 10 studies | 27% ± 9% | |
macrophage | 9 studies | 28% ± 9% | |
oligodendrocyte | 9 studies | 27% ± 7% | |
glutamatergic neuron | 8 studies | 41% ± 23% | |
adipocyte | 8 studies | 28% ± 7% | |
fibroblast | 8 studies | 28% ± 12% | |
oligodendrocyte precursor cell | 8 studies | 29% ± 12% | |
type I pneumocyte | 7 studies | 24% ± 10% | |
epithelial cell | 6 studies | 39% ± 19% | |
retinal cone cell | 6 studies | 27% ± 4% | |
GABAergic neuron | 6 studies | 41% ± 20% | |
neuron | 5 studies | 34% ± 15% | |
dendritic cell | 5 studies | 20% ± 3% | |
club cell | 5 studies | 22% ± 7% | |
smooth muscle cell | 5 studies | 24% ± 5% | |
type II pneumocyte | 5 studies | 23% ± 7% | |
cardiac muscle cell | 4 studies | 28% ± 4% | |
ciliated cell | 4 studies | 30% ± 13% | |
lymphocyte | 4 studies | 24% ± 7% | |
myeloid cell | 4 studies | 24% ± 5% | |
retinal rod cell | 4 studies | 21% ± 6% | |
endothelial cell of lymphatic vessel | 4 studies | 26% ± 6% | |
interneuron | 4 studies | 42% ± 22% | |
squamous epithelial cell | 3 studies | 31% ± 14% | |
GABAergic interneuron | 3 studies | 20% ± 4% | |
hepatocyte | 3 studies | 38% ± 25% | |
retinal pigment epithelial cell | 3 studies | 40% ± 21% | |
abnormal cell | 3 studies | 31% ± 21% | |
ependymal cell | 3 studies | 39% ± 6% | |
monocyte | 3 studies | 22% ± 4% | |
pericyte | 3 studies | 32% ± 9% | |
mast cell | 3 studies | 21% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3468.84 | 1445 / 1445 | 100% | 50.04 | 183 / 183 |
lung | 100% | 4222.68 | 578 / 578 | 100% | 51.13 | 1155 / 1155 |
ovary | 100% | 3441.69 | 180 / 180 | 100% | 70.26 | 430 / 430 |
breast | 100% | 3378.43 | 459 / 459 | 100% | 65.96 | 1113 / 1118 |
skin | 100% | 4908.69 | 1809 / 1809 | 99% | 58.47 | 469 / 472 |
stomach | 100% | 2474.96 | 359 / 359 | 99% | 34.58 | 284 / 286 |
intestine | 100% | 3084.48 | 966 / 966 | 99% | 29.66 | 523 / 527 |
bladder | 100% | 3255.19 | 21 / 21 | 99% | 37.25 | 500 / 504 |
thymus | 100% | 3871.91 | 653 / 653 | 98% | 37.17 | 595 / 605 |
brain | 99% | 2067.93 | 2608 / 2642 | 100% | 39.31 | 702 / 705 |
prostate | 100% | 3378.86 | 245 / 245 | 98% | 34.11 | 493 / 502 |
kidney | 100% | 3033.57 | 89 / 89 | 98% | 27.72 | 884 / 901 |
uterus | 100% | 3702.08 | 170 / 170 | 98% | 46.76 | 450 / 459 |
pancreas | 99% | 1401.41 | 326 / 328 | 98% | 33.19 | 175 / 178 |
adrenal gland | 100% | 3422.37 | 258 / 258 | 95% | 27.79 | 219 / 230 |
liver | 100% | 1820.94 | 226 / 226 | 90% | 22.96 | 364 / 406 |
adipose | 100% | 3378.43 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 42.41 | 29 / 29 |
muscle | 100% | 2616.98 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3640.76 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 24.28 | 1 / 1 |
blood vessel | 100% | 3142.90 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 2319.32 | 846 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 33.77 | 43 / 45 |
eye | 0% | 0 | 0 / 0 | 93% | 22.28 | 74 / 80 |
peripheral blood | 89% | 2220.70 | 826 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051896 | Biological process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0030216 | Biological process | keratinocyte differentiation |
GO_0006650 | Biological process | glycerophospholipid metabolic process |
GO_0072659 | Biological process | protein localization to plasma membrane |
GO_0090630 | Biological process | activation of GTPase activity |
GO_0007165 | Biological process | signal transduction |
GO_0010761 | Biological process | fibroblast migration |
GO_0046854 | Biological process | phosphatidylinositol phosphate biosynthetic process |
GO_0097178 | Biological process | ruffle assembly |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0008654 | Biological process | phospholipid biosynthetic process |
GO_0006909 | Biological process | phagocytosis |
GO_0048041 | Biological process | focal adhesion assembly |
GO_0016477 | Biological process | cell migration |
GO_0060326 | Biological process | cell chemotaxis |
GO_0006661 | Biological process | phosphatidylinositol biosynthetic process |
GO_0032587 | Cellular component | ruffle membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0016607 | Cellular component | nuclear speck |
GO_0005847 | Cellular component | mRNA cleavage and polyadenylation specificity factor complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005925 | Cellular component | focal adhesion |
GO_0005829 | Cellular component | cytosol |
GO_0030027 | Cellular component | lamellipodium |
GO_0005634 | Cellular component | nucleus |
GO_0052742 | Molecular function | phosphatidylinositol kinase activity |
GO_0016308 | Molecular function | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
GO_0019900 | Molecular function | kinase binding |
GO_0000285 | Molecular function | 1-phosphatidylinositol-3-phosphate 5-kinase activity |
GO_0052810 | Molecular function | 1-phosphatidylinositol-5-kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | PIP5K1A |
Protein name | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) |
Synonyms | |
Description | FUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility . PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) . PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Can also use phosphatidylinositol (PtdIns) as substrate in vitro . Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle ingestion by activating the WAS GTPase-binding protein that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup (By similarity). Together with PIP5K1B, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity). Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, IP3 and DAG, that will mobilize internal calcium and drive keratinocyte differentiation . Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Together with PIP5K1C has a role during embryogenesis (By similarity). Independently of its catalytic activity, is required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of the small GTPase RAC1 to the plasma membrane . Also functions in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs . . |
Accessions | E9PSF8 ENST00000349792.9 [Q99755-3] ENST00000418435.1 ENST00000424999.1 ENST00000454769.2 A6PW57 Q99755 A6PW56 A6PW58 ENST00000441902.6 [Q99755-4] ENST00000409426.5 A2A5X0 ENST00000447555.5 ENST00000368890.8 [Q99755-2] ENST00000368888.9 [Q99755-1] |