ARF6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	35 studies	42% ± 14%	Explore
CD8-positive, alpha-beta T cell	33 studies	35% ± 11%	Explore
B cell	32 studies	36% ± 13%	Explore
CD4-positive, alpha-beta T cell	31 studies	30% ± 11%	Explore
T cell	29 studies	36% ± 14%	Explore
macrophage	27 studies	29% ± 10%	Explore
conventional dendritic cell	24 studies	46% ± 19%	Explore
classical monocyte	24 studies	35% ± 18%	Explore
regulatory T cell	22 studies	33% ± 10%	Explore
non-classical monocyte	20 studies	38% ± 18%	Explore
mature NK T cell	19 studies	36% ± 14%	Explore
dendritic cell	18 studies	43% ± 22%	Explore
endothelial cell	18 studies	30% ± 12%	Explore
monocyte	17 studies	29% ± 11%	Explore
memory B cell	17 studies	36% ± 14%	Explore
naive B cell	17 studies	32% ± 12%	Explore
gamma-delta T cell	16 studies	40% ± 14%	Explore
plasmacytoid dendritic cell	15 studies	30% ± 12%	Explore
epithelial cell	15 studies	46% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	43% ± 18%	Explore
basal cell	14 studies	40% ± 18%	Explore
mast cell	13 studies	29% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	46% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	26% ± 12%	Explore
smooth muscle cell	13 studies	21% ± 5%	Explore
mucosal invariant T cell	13 studies	29% ± 9%	Explore
fibroblast	13 studies	28% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	41% ± 17%	Explore
plasma cell	10 studies	31% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	34% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	35% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	41% ± 17%	Explore
capillary endothelial cell	9 studies	19% ± 4%	Explore
pericyte	9 studies	24% ± 7%	Explore
endothelial cell of vascular tree	9 studies	33% ± 12%	Explore
myeloid cell	9 studies	40% ± 23%	Explore
secretory cell	8 studies	34% ± 20%	Explore
leukocyte	8 studies	34% ± 7%	Explore
T follicular helper cell	8 studies	39% ± 14%	Explore
endothelial cell of lymphatic vessel	7 studies	31% ± 8%	Explore
endothelial cell of artery	7 studies	25% ± 6%	Explore
goblet cell	7 studies	23% ± 7%	Explore
innate lymphoid cell	7 studies	41% ± 12%	Explore
ciliated cell	7 studies	36% ± 14%	Explore
alveolar macrophage	6 studies	26% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	34% ± 8%	Explore
enterocyte	6 studies	25% ± 5%	Explore
vein endothelial cell	6 studies	24% ± 6%	Explore
abnormal cell	6 studies	26% ± 12%	Explore
connective tissue cell	6 studies	26% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	40% ± 14%	Explore
plasmablast	5 studies	42% ± 18%	Explore
exhausted T cell	5 studies	36% ± 13%	Explore
mononuclear phagocyte	5 studies	38% ± 16%	Explore
transit amplifying cell	5 studies	23% ± 6%	Explore
precursor B cell	5 studies	33% ± 19%	Explore
immature B cell	5 studies	32% ± 9%	Explore
squamous epithelial cell	4 studies	52% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	35% ± 6%	Explore
hematopoietic precursor cell	4 studies	41% ± 16%	Explore
kidney loop of Henle epithelial cell	4 studies	19% ± 3%	Explore
pro-B cell	4 studies	34% ± 20%	Explore
CD4-positive helper T cell	4 studies	37% ± 17%	Explore
group 3 innate lymphoid cell	4 studies	47% ± 8%	Explore
T-helper 17 cell	4 studies	42% ± 13%	Explore
T-helper 1 cell	4 studies	48% ± 4%	Explore
monocyte-derived dendritic cell	3 studies	56% ± 25%	Explore
podocyte	3 studies	33% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	17% ± 1%	Explore
progenitor cell	3 studies	17% ± 3%	Explore
thymocyte	3 studies	24% ± 5%	Explore
lymphocyte	3 studies	41% ± 17%	Explore
myofibroblast cell	3 studies	24% ± 8%	Explore
brush cell	3 studies	32% ± 13%	Explore
intraepithelial lymphocyte	3 studies	28% ± 8%	Explore
germinal center B cell	3 studies	34% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	40% ± 10%	Explore
granulocyte	3 studies	34% ± 13%	Explore
luminal cell of prostate epithelium	3 studies	56% ± 12%	Explore
type I pneumocyte	3 studies	32% ± 9%	Explore
pancreatic ductal cell	3 studies	48% ± 14%	Explore
keratinocyte	3 studies	39% ± 28%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	25% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	37% ± 16%	Explore
lung	14 studies	33% ± 12%	Explore
intestine	10 studies	22% ± 5%	Explore
lymph node	6 studies	25% ± 11%	Explore
kidney	5 studies	22% ± 4%	Explore
bone marrow	4 studies	34% ± 20%	Explore
uterus	4 studies	34% ± 12%	Explore
breast	4 studies	29% ± 10%	Explore
liver	4 studies	33% ± 12%	Explore
placenta	3 studies	25% ± 5%	Explore
prostate	3 studies	50% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	5961.61	966 / 966	100%	142.08	527 / 527
prostate	100%	4212.43	245 / 245	100%	185.73	502 / 502
stomach	100%	3887.14	359 / 359	100%	119.60	286 / 286
esophagus	100%	8787.24	1444 / 1445	100%	147.07	183 / 183
breast	100%	5344.31	459 / 459	100%	188.85	1116 / 1118
bladder	100%	4753.00	21 / 21	100%	155.46	503 / 504
lung	100%	5477.57	576 / 578	100%	143.27	1155 / 1155
uterus	100%	3663.28	170 / 170	100%	185.12	457 / 459
skin	100%	11029.60	1809 / 1809	99%	128.15	469 / 472
thymus	100%	3622.55	652 / 653	99%	117.53	600 / 605
kidney	100%	4695.22	89 / 89	99%	104.86	892 / 901
liver	100%	3047.48	226 / 226	98%	69.26	397 / 406
ovary	98%	2512.48	176 / 180	100%	123.93	430 / 430
adrenal gland	100%	4021.62	258 / 258	92%	59.73	212 / 230
brain	92%	1868.30	2423 / 2642	100%	56.98	702 / 705
pancreas	87%	1733.58	286 / 328	99%	138.27	176 / 178
adipose	100%	5349.92	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	156.25	29 / 29
spleen	100%	6593.19	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	194.16	45 / 45
ureter	0%	0	0 / 0	100%	80.99	1 / 1
blood vessel	100%	4517.29	1330 / 1335	0%	0	0 / 0
muscle	99%	2783.13	791 / 803	0%	0	0 / 0
peripheral blood	98%	6810.38	914 / 929	0%	0	0 / 0
heart	92%	2126.96	791 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	90%	54.57	72 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051489	Biological process	regulation of filopodium assembly
GO_0030838	Biological process	positive regulation of actin filament polymerization
GO_1902217	Biological process	erythrocyte apoptotic process
GO_0072659	Biological process	protein localization to plasma membrane
GO_0035020	Biological process	regulation of Rac protein signal transduction
GO_1905606	Biological process	regulation of presynapse assembly
GO_0090162	Biological process	establishment of epithelial cell polarity
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0048488	Biological process	synaptic vesicle endocytosis
GO_0099562	Biological process	maintenance of postsynaptic density structure
GO_0006886	Biological process	intracellular protein transport
GO_0051301	Biological process	cell division
GO_0001889	Biological process	liver development
GO_0007155	Biological process	cell adhesion
GO_0097178	Biological process	ruffle assembly
GO_0032456	Biological process	endocytic recycling
GO_0034394	Biological process	protein localization to cell surface
GO_1903438	Biological process	positive regulation of mitotic cytokinetic process
GO_0050714	Biological process	positive regulation of protein secretion
GO_0016192	Biological process	vesicle-mediated transport
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0060998	Biological process	regulation of dendritic spine development
GO_0051549	Biological process	positive regulation of keratinocyte migration
GO_0030154	Biological process	cell differentiation
GO_1990090	Biological process	cellular response to nerve growth factor stimulus
GO_0097284	Biological process	hepatocyte apoptotic process
GO_2000009	Biological process	negative regulation of protein localization to cell surface
GO_1905345	Biological process	protein localization to cleavage furrow
GO_0120183	Biological process	positive regulation of focal adhesion disassembly
GO_0048261	Biological process	negative regulation of receptor-mediated endocytosis
GO_0030866	Biological process	cortical actin cytoskeleton organization
GO_0036010	Biological process	protein localization to endosome
GO_2000171	Biological process	negative regulation of dendrite development
GO_0007399	Biological process	nervous system development
GO_0001726	Cellular component	ruffle
GO_0098978	Cellular component	glutamatergic synapse
GO_0098793	Cellular component	presynapse
GO_0030496	Cellular component	midbody
GO_0005886	Cellular component	plasma membrane
GO_0030139	Cellular component	endocytic vesicle
GO_0016020	Cellular component	membrane
GO_0031901	Cellular component	early endosome membrane
GO_0055038	Cellular component	recycling endosome membrane
GO_0070062	Cellular component	extracellular exosome
GO_0098794	Cellular component	postsynapse
GO_0005794	Cellular component	Golgi apparatus
GO_0005925	Cellular component	focal adhesion
GO_0090543	Cellular component	Flemming body
GO_0031527	Cellular component	filopodium membrane
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0005737	Cellular component	cytoplasm
GO_0032154	Cellular component	cleavage furrow
GO_0005768	Cellular component	endosome
GO_0019003	Molecular function	GDP binding
GO_0031996	Molecular function	thioesterase binding
GO_0003925	Molecular function	G protein activity
GO_0005525	Molecular function	GTP binding
GO_0035591	Molecular function	signaling adaptor activity
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	ARF6
Protein name	ADP-ribosylation factor 6 ADP ribosylation factor 6 ADP-ribosylation factor 6 (EC 3.6.5.2)
Synonyms
Description	FUNCTION: GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling . GTP-bound form plays an important role in the transport of multiple palmitoylated proteins form the Golgi to the plasma membrane . Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension . Potentiates the neurite outgrowth in primary neurons by interacting with the molecular adapter APBB1 . Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization . Regulates surface levels of adherens junction proteins such as CDH1 (By similarity). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity). .; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. .; FUNCTION: (Microbial infection) Plays a key role in the endocytosis of enterovirus 71 and thus viral entry into brain microvascular endothelial cells. .
Accessions	ENST00000298316.7 A0A8I5QJX7 Q6FH17 ENST00000692608.1 P62330 ENST00000693319.1

ARF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review