FLNB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	39 studies	35% ± 14%	Explore
endothelial cell of lymphatic vessel	18 studies	30% ± 11%	Explore
ciliated cell	16 studies	39% ± 21%	Explore
plasmacytoid dendritic cell	13 studies	30% ± 5%	Explore
endothelial cell of artery	12 studies	32% ± 7%	Explore
vein endothelial cell	12 studies	34% ± 15%	Explore
type I pneumocyte	11 studies	31% ± 10%	Explore
epithelial cell	11 studies	34% ± 15%	Explore
capillary endothelial cell	10 studies	23% ± 8%	Explore
basal cell	10 studies	29% ± 11%	Explore
club cell	8 studies	33% ± 10%	Explore
fibroblast	8 studies	27% ± 7%	Explore
endothelial cell of vascular tree	8 studies	32% ± 18%	Explore
respiratory goblet cell	6 studies	39% ± 15%	Explore
goblet cell	6 studies	31% ± 22%	Explore
smooth muscle cell	6 studies	20% ± 4%	Explore
glutamatergic neuron	5 studies	45% ± 22%	Explore
enterocyte	5 studies	24% ± 4%	Explore
GABAergic neuron	5 studies	42% ± 20%	Explore
secretory cell	4 studies	24% ± 4%	Explore
endothelial cell of sinusoid	4 studies	37% ± 20%	Explore
interneuron	4 studies	33% ± 14%	Explore
oligodendrocyte precursor cell	4 studies	19% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	28% ± 8%	Explore
hepatocyte	4 studies	49% ± 14%	Explore
luminal cell of prostate epithelium	4 studies	31% ± 9%	Explore
type II pneumocyte	4 studies	19% ± 5%	Explore
mucus secreting cell	4 studies	29% ± 2%	Explore
oligodendrocyte	4 studies	29% ± 7%	Explore
hillock cell	3 studies	22% ± 3%	Explore
ionocyte	3 studies	23% ± 4%	Explore
granule cell	3 studies	24% ± 1%	Explore
neuron	3 studies	46% ± 14%	Explore
progenitor cell	3 studies	25% ± 9%	Explore
extravillous trophoblast	3 studies	64% ± 20%	Explore
dendritic cell	3 studies	20% ± 4%	Explore
connective tissue cell	3 studies	33% ± 16%	Explore
enteroendocrine cell	3 studies	24% ± 7%	Explore
cardiac muscle cell	3 studies	23% ± 2%	Explore
renal alpha-intercalated cell	3 studies	22% ± 5%	Explore
kidney loop of Henle epithelial cell	3 studies	23% ± 2%	Explore
renal principal cell	3 studies	23% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	6 studies	24% ± 7%	Explore
brain	6 studies	35% ± 15%	Explore
intestine	3 studies	18% ± 2%	Explore
adipose	3 studies	21% ± 1%	Explore
kidney	3 studies	21% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	23078.37	245 / 245	100%	168.65	502 / 502
breast	100%	19973.95	459 / 459	99%	177.15	1112 / 1118
thymus	100%	19917.79	653 / 653	99%	78.71	597 / 605
esophagus	100%	11380.82	1445 / 1445	98%	109.95	180 / 183
pancreas	99%	9786.24	325 / 328	99%	143.83	176 / 178
intestine	100%	20479.75	966 / 966	98%	97.94	516 / 527
stomach	100%	11082.16	359 / 359	98%	90.58	280 / 286
bladder	100%	23601.86	21 / 21	98%	90.09	492 / 504
kidney	100%	12447.03	89 / 89	95%	72.49	860 / 901
lung	99%	9981.18	574 / 578	96%	69.30	1110 / 1155
uterus	100%	19408.93	170 / 170	95%	78.96	436 / 459
liver	100%	7348.92	225 / 226	88%	38.45	357 / 406
ovary	100%	13286.72	180 / 180	84%	40.04	361 / 430
skin	100%	18331.97	1809 / 1809	77%	35.93	364 / 472
adrenal gland	100%	11938.08	257 / 258	47%	16.46	108 / 230
brain	86%	5263.91	2270 / 2642	53%	14.62	374 / 705
adipose	100%	14536.95	1204 / 1204	0%	0	0 / 0
blood vessel	100%	12046.73	1335 / 1335	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	149.64	1 / 1
spleen	100%	9551.90	240 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	87.14	43 / 45
heart	87%	4236.57	747 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	38%	10.85	11 / 29
eye	0%	0	0 / 0	25%	5.93	20 / 80
muscle	21%	750.36	168 / 803	0%	0	0 / 0
peripheral blood	20%	1414.19	189 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007519	Biological process	skeletal muscle tissue development
GO_0007165	Biological process	signal transduction
GO_0003382	Biological process	epithelial cell morphogenesis
GO_0030036	Biological process	actin cytoskeleton organization
GO_0003334	Biological process	keratinocyte development
GO_0071346	Biological process	cellular response to type II interferon
GO_0005903	Cellular component	brush border
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0030018	Cellular component	Z disc
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0001725	Cellular component	stress fiber
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0045335	Cellular component	phagocytic vesicle
GO_0005938	Cellular component	cell cortex
GO_0005737	Cellular component	cytoplasm
GO_0045296	Molecular function	cadherin binding
GO_0051015	Molecular function	actin filament binding
GO_0042802	Molecular function	identical protein binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	FLNB
Protein name	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) Filamin B
Synonyms	FLN3 TAP FLN1L TABP
Description	FUNCTION: Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
Accessions	A0A804HL72 ENST00000682097.1 A0A0C4DGA1 ENST00000470231.1 ENST00000466455.1 ENST00000358537.7 [O75369-2] ENST00000429972.6 [O75369-9] H7C5L4 ENST00000682871.1 ENST00000493452.5 ENST00000684506.1 A0A804HJC2 O75369 ENST00000490882.5 [O75369-8] ENST00000684517.1 ENST00000295956.9 [O75369-1] ENST00000684607.1 E7EN95 A0A804HK76 ENST00000684107.1

FLNB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review