VASP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0008154Biological processactin polymerization or depolymerization
GO_0030036Biological processactin cytoskeleton organization
GO_0001843Biological processneural tube closure
GO_0007411Biological processaxon guidance
GO_0051289Biological processprotein homotetramerization
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0031527Cellular componentfilopodium membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0031258Cellular componentlamellipodium membrane
GO_0005829Cellular componentcytosol
GO_0005923Cellular componentbicellular tight junction
GO_0045296Molecular functioncadherin binding
GO_0005522Molecular functionprofilin binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameVASP
Protein nameVasodilator-stimulated phosphoprotein isoform 3
Vasodilator-stimulated phosphoprotein isoform 1
Vasodilator-stimulated phosphoprotein isoform 2
Vasodilator-stimulated phosphoprotein (VASP)
Vasodilator stimulated phosphoprotein
Vasodilator-stimulated phosphoprotein isoform 4
Vasodilator-stimulated phosphoprotein isoform 5
Synonyms
DescriptionFUNCTION: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. .

AccessionsA0A994J508
K7ENR7
A0A0S2Z4I9
P50552
ENST00000586014.5
ENST00000589627.1
ENST00000245932.11
A0A0S2Z4H6
K7ENL7
A0A0S2Z4I7
K7EQD0
ENST00000592139.1
K7EIG8
ENST00000588482.5
ENST00000705986.1
A0A024R0V4
K7EM16
A0A994J7X3
ENST00000590603.1
A0A0S2Z4N8
ENST00000705987.1