CAV2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051480Biological processregulation of cytosolic calcium ion concentration
GO_0060161Biological processpositive regulation of dopamine receptor signaling pathway
GO_0014859Biological processnegative regulation of skeletal muscle cell proliferation
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0043547Biological processpositive regulation of GTPase activity
GO_0014856Biological processskeletal muscle cell proliferation
GO_0048741Biological processskeletal muscle fiber development
GO_0007029Biological processendoplasmic reticulum organization
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0044794Biological processpositive regulation by host of viral process
GO_0070836Biological processcaveola assembly
GO_0071711Biological processbasement membrane organization
GO_0001937Biological processnegative regulation of endothelial cell proliferation
GO_0007005Biological processmitochondrion organization
GO_0008286Biological processinsulin receptor signaling pathway
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0030154Biological processcell differentiation
GO_0016050Biological processvesicle organization
GO_0001935Biological processendothelial cell proliferation
GO_0048278Biological processvesicle docking
GO_0019065Biological processreceptor-mediated endocytosis of virus by host cell
GO_0019076Biological processviral release from host cell
GO_0006906Biological processvesicle fusion
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0007088Biological processregulation of mitotic nuclear division
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0002080Cellular componentacrosomal membrane
GO_0042383Cellular componentsarcolemma
GO_0032991Cellular componentprotein-containing complex
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0044853Cellular componentplasma membrane raft
GO_0000139Cellular componentGolgi membrane
GO_0002095Cellular componentcaveolar macromolecular signaling complex
GO_0030133Cellular componenttransport vesicle
GO_0005901Cellular componentcaveola
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0019901Molecular functionprotein kinase binding
GO_0097110Molecular functionscaffold protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCAV2
Protein nameCaveolin-2
Caveolin
SynonymshCG_39087
tcag7.25
DescriptionFUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). .

FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression. .

FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression. .

AccessionsENST00000343213.2 [P51636-3]
ENST00000222693.5 [P51636-1]
Q53X57
ENST00000393480.3
E9PCT3
P51636