MSN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	48 studies	47% ± 15%	Explore
natural killer cell	43 studies	53% ± 16%	Explore
macrophage	42 studies	38% ± 13%	Explore
B cell	36 studies	32% ± 10%	Explore
CD8-positive, alpha-beta T cell	36 studies	42% ± 14%	Explore
T cell	35 studies	38% ± 13%	Explore
CD4-positive, alpha-beta T cell	35 studies	38% ± 12%	Explore
fibroblast	32 studies	25% ± 9%	Explore
pericyte	30 studies	34% ± 15%	Explore
smooth muscle cell	29 studies	27% ± 9%	Explore
classical monocyte	28 studies	56% ± 16%	Explore
conventional dendritic cell	26 studies	51% ± 18%	Explore
non-classical monocyte	25 studies	68% ± 16%	Explore
regulatory T cell	25 studies	36% ± 10%	Explore
monocyte	24 studies	48% ± 14%	Explore
endothelial cell of lymphatic vessel	22 studies	36% ± 12%	Explore
mature NK T cell	22 studies	48% ± 14%	Explore
dendritic cell	21 studies	46% ± 20%	Explore
mast cell	21 studies	30% ± 16%	Explore
memory B cell	20 studies	37% ± 9%	Explore
gamma-delta T cell	19 studies	49% ± 14%	Explore
naive B cell	19 studies	34% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	32% ± 10%	Explore
myeloid cell	18 studies	40% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	55% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	63% ± 16%	Explore
mucosal invariant T cell	15 studies	44% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	40% ± 14%	Explore
capillary endothelial cell	15 studies	50% ± 14%	Explore
endothelial cell of vascular tree	14 studies	53% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	49% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	51% ± 11%	Explore
endothelial cell of artery	13 studies	50% ± 13%	Explore
vein endothelial cell	13 studies	57% ± 17%	Explore
type I pneumocyte	12 studies	38% ± 12%	Explore
type II pneumocyte	12 studies	35% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	41% ± 12%	Explore
platelet	11 studies	44% ± 14%	Explore
neutrophil	11 studies	34% ± 11%	Explore
leukocyte	11 studies	39% ± 15%	Explore
microglial cell	11 studies	34% ± 13%	Explore
myofibroblast cell	11 studies	30% ± 11%	Explore
alveolar macrophage	8 studies	41% ± 11%	Explore
innate lymphoid cell	8 studies	44% ± 12%	Explore
plasmablast	8 studies	45% ± 17%	Explore
plasmacytoid dendritic cell	8 studies	26% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	53% ± 18%	Explore
hematopoietic stem cell	8 studies	53% ± 15%	Explore
connective tissue cell	8 studies	28% ± 9%	Explore
mononuclear phagocyte	7 studies	39% ± 12%	Explore
basal cell	7 studies	23% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	44% ± 13%	Explore
hematopoietic precursor cell	6 studies	56% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	49% ± 15%	Explore
lymphocyte	6 studies	50% ± 13%	Explore
T follicular helper cell	6 studies	34% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	51% ± 7%	Explore
CD4-positive helper T cell	5 studies	36% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	44% ± 16%	Explore
plasma cell	5 studies	29% ± 14%	Explore
exhausted T cell	5 studies	55% ± 12%	Explore
precursor B cell	5 studies	43% ± 12%	Explore
pro-B cell	5 studies	36% ± 19%	Explore
epithelial cell	5 studies	28% ± 11%	Explore
T-helper 17 cell	5 studies	45% ± 14%	Explore
abnormal cell	5 studies	32% ± 11%	Explore
intermediate monocyte	5 studies	63% ± 23%	Explore
glomerular endothelial cell	4 studies	48% ± 10%	Explore
mesothelial cell	4 studies	19% ± 2%	Explore
granulocyte	4 studies	33% ± 14%	Explore
astrocyte	4 studies	29% ± 3%	Explore
double negative thymocyte	4 studies	53% ± 6%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	43% ± 10%	Explore
monocyte-derived dendritic cell	3 studies	50% ± 25%	Explore
megakaryocyte	3 studies	67% ± 9%	Explore
immature B cell	3 studies	41% ± 9%	Explore
glial cell	3 studies	25% ± 11%	Explore
tissue-resident macrophage	3 studies	33% ± 7%	Explore
intraepithelial lymphocyte	3 studies	35% ± 14%	Explore
kidney loop of Henle epithelial cell	3 studies	17% ± 0%	Explore
germinal center B cell	3 studies	26% ± 7%	Explore
neuron	3 studies	29% ± 9%	Explore
muscle cell	3 studies	41% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	78% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	57% ± 13%	Explore
progenitor cell	3 studies	41% ± 14%	Explore
T-helper 1 cell	3 studies	48% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	43% ± 7%	Explore
mural cell	3 studies	38% ± 10%	Explore
erythrocyte	3 studies	33% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	47% ± 12%	Explore
lung	17 studies	33% ± 11%	Explore
kidney	7 studies	29% ± 14%	Explore
brain	6 studies	23% ± 7%	Explore
bone marrow	5 studies	42% ± 21%	Explore
uterus	5 studies	29% ± 3%	Explore
adipose	5 studies	22% ± 11%	Explore
liver	5 studies	29% ± 10%	Explore
intestine	4 studies	22% ± 6%	Explore
heart	4 studies	22% ± 2%	Explore
lymph node	4 studies	38% ± 9%	Explore
breast	4 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	26174.33	652 / 653	100%	508.11	604 / 605
skin	100%	25167.15	1807 / 1809	99%	518.44	469 / 472
kidney	100%	21351.20	89 / 89	97%	369.24	874 / 901
lung	100%	52559.41	578 / 578	97%	328.07	1120 / 1155
breast	100%	28233.53	459 / 459	97%	215.10	1082 / 1118
ovary	99%	14319.84	179 / 180	96%	196.61	413 / 430
esophagus	98%	20119.29	1422 / 1445	94%	319.65	172 / 183
uterus	100%	26555.59	170 / 170	91%	245.30	419 / 459
adrenal gland	98%	15389.82	254 / 258	82%	141.29	189 / 230
bladder	100%	23656.81	21 / 21	68%	142.86	341 / 504
intestine	97%	18894.10	939 / 966	70%	97.85	369 / 527
prostate	97%	14597.02	238 / 245	67%	69.44	335 / 502
stomach	75%	11842.06	270 / 359	77%	129.15	221 / 286
brain	60%	5374.29	1575 / 2642	67%	160.29	474 / 705
liver	56%	6593.00	127 / 226	65%	92.03	265 / 406
pancreas	24%	1956.48	79 / 328	93%	224.66	165 / 178
adipose	100%	37306.23	1204 / 1204	0%	0	0 / 0
blood vessel	100%	43992.66	1335 / 1335	0%	0	0 / 0
spleen	100%	27734.90	241 / 241	0%	0	0 / 0
peripheral blood	100%	52615.80	926 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	99%	221.08	79 / 80
heart	97%	15796.59	834 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	343.24	28 / 29
tonsil	0%	0	0 / 0	96%	326.69	43 / 45
muscle	58%	4703.87	466 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0071803	Biological process	positive regulation of podosome assembly
GO_0022614	Biological process	membrane to membrane docking
GO_0045198	Biological process	establishment of epithelial cell apical/basal polarity
GO_0001771	Biological process	immunological synapse formation
GO_2000401	Biological process	regulation of lymphocyte migration
GO_0042098	Biological process	T cell proliferation
GO_0070489	Biological process	T cell aggregation
GO_2000643	Biological process	positive regulation of early endosome to late endosome transport
GO_0010628	Biological process	positive regulation of gene expression
GO_0007010	Biological process	cytoskeleton organization
GO_0071394	Biological process	cellular response to testosterone stimulus
GO_1902966	Biological process	positive regulation of protein localization to early endosome
GO_0045732	Biological process	positive regulation of protein catabolic process
GO_1902115	Biological process	regulation of organelle assembly
GO_0050900	Biological process	leukocyte migration
GO_0022612	Biological process	gland morphogenesis
GO_0008360	Biological process	regulation of cell shape
GO_0061028	Biological process	establishment of endothelial barrier
GO_0008361	Biological process	regulation of cell size
GO_0072678	Biological process	T cell migration
GO_0007159	Biological process	leukocyte cell-cell adhesion
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005902	Cellular component	microvillus
GO_0005615	Cellular component	extracellular space
GO_0016324	Cellular component	apical plasma membrane
GO_0005856	Cellular component	cytoskeleton
GO_0031982	Cellular component	vesicle
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0031528	Cellular component	microvillus membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0072562	Cellular component	blood microparticle
GO_0009986	Cellular component	cell surface
GO_0030175	Cellular component	filopodium
GO_0005829	Cellular component	cytosol
GO_0071944	Cellular component	cell periphery
GO_0005912	Cellular component	adherens junction
GO_0005737	Cellular component	cytoplasm
GO_0031143	Cellular component	pseudopodium
GO_0001931	Cellular component	uropod
GO_0045177	Cellular component	apical part of cell
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0019901	Molecular function	protein kinase binding
GO_0005102	Molecular function	signaling receptor binding
GO_0050839	Molecular function	cell adhesion molecule binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding
GO_0003725	Molecular function	double-stranded RNA binding

IV. Literature review

[source]

Gene name	MSN
Protein name	Moesin Moesin (Membrane-organizing extension spike protein)
Synonyms	HEL70 hCG_18939
Description	FUNCTION: Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton . Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement . These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction . The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs . Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation . .
Accessions	A0A8V8TKR9 ENST00000697138.1 V9HWC0 A0A8V8TKQ0 ENST00000697134.1 Q6PJT4 P26038 ENST00000609672.5 V9GZ54 ENST00000697137.1 ENST00000697133.1 ENST00000360270.7

MSN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review