LAP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006508Biological processproteolysis
GO_0005802Cellular componenttrans-Golgi network
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0030145Molecular functionmanganese ion binding
GO_0008233Molecular functionpeptidase activity
GO_0008235Molecular functionmetalloexopeptidase activity
GO_0004180Molecular functioncarboxypeptidase activity
GO_0005515Molecular functionprotein binding
GO_0070006Molecular functionmetalloaminopeptidase activity
GO_0004177Molecular functionaminopeptidase activity

IV. Literature review

[source]
Gene nameLAP3
Protein nameLeucine aminopeptidase 3
Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase)
SynonymsPEPS
LAPEP
DescriptionFUNCTION: Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. .

AccessionsENST00000606142.5 [P28838-2]
P28838
ENST00000226299.9 [P28838-1]
ENST00000513105.1
H0Y9Q1
ENST00000618908.4 [P28838-1]