AHNAK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	44 studies	45% ± 20%	Explore
endothelial cell	43 studies	43% ± 17%	Explore
macrophage	37 studies	39% ± 17%	Explore
natural killer cell	34 studies	38% ± 18%	Explore
pericyte	32 studies	42% ± 17%	Explore
smooth muscle cell	30 studies	38% ± 17%	Explore
B cell	29 studies	36% ± 12%	Explore
classical monocyte	27 studies	64% ± 18%	Explore
CD8-positive, alpha-beta T cell	26 studies	39% ± 16%	Explore
CD4-positive, alpha-beta T cell	25 studies	38% ± 15%	Explore
mast cell	24 studies	54% ± 16%	Explore
conventional dendritic cell	24 studies	56% ± 19%	Explore
non-classical monocyte	23 studies	54% ± 16%	Explore
regulatory T cell	23 studies	36% ± 12%	Explore
T cell	22 studies	39% ± 18%	Explore
monocyte	22 studies	40% ± 17%	Explore
endothelial cell of lymphatic vessel	21 studies	51% ± 19%	Explore
basal cell	20 studies	49% ± 20%	Explore
dendritic cell	19 studies	58% ± 23%	Explore
plasmacytoid dendritic cell	19 studies	40% ± 15%	Explore
epithelial cell	18 studies	42% ± 22%	Explore
mature NK T cell	17 studies	42% ± 13%	Explore
ciliated cell	17 studies	44% ± 19%	Explore
memory B cell	16 studies	43% ± 15%	Explore
mucosal invariant T cell	15 studies	51% ± 17%	Explore
connective tissue cell	15 studies	43% ± 16%	Explore
myofibroblast cell	15 studies	40% ± 15%	Explore
plasma cell	14 studies	37% ± 12%	Explore
gamma-delta T cell	14 studies	51% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	49% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	14 studies	48% ± 19%	Explore
naive B cell	14 studies	26% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	47% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	50% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	28% ± 10%	Explore
capillary endothelial cell	13 studies	40% ± 12%	Explore
endothelial cell of vascular tree	13 studies	41% ± 19%	Explore
myeloid cell	13 studies	39% ± 18%	Explore
type I pneumocyte	12 studies	52% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	53% ± 16%	Explore
endothelial cell of artery	12 studies	48% ± 9%	Explore
vein endothelial cell	12 studies	47% ± 13%	Explore
secretory cell	11 studies	47% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	32% ± 12%	Explore
mesothelial cell	10 studies	44% ± 11%	Explore
adipocyte	9 studies	40% ± 8%	Explore
alveolar macrophage	8 studies	46% ± 16%	Explore
innate lymphoid cell	8 studies	32% ± 12%	Explore
plasmablast	8 studies	51% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	49% ± 16%	Explore
abnormal cell	8 studies	39% ± 13%	Explore
goblet cell	8 studies	35% ± 17%	Explore
astrocyte	8 studies	32% ± 12%	Explore
club cell	7 studies	48% ± 19%	Explore
respiratory goblet cell	7 studies	55% ± 19%	Explore
mononuclear phagocyte	7 studies	41% ± 11%	Explore
type II pneumocyte	6 studies	21% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	50% ± 14%	Explore
enterocyte	6 studies	29% ± 7%	Explore
lymphocyte	6 studies	40% ± 14%	Explore
IgA plasma cell	6 studies	36% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	60% ± 6%	Explore
CD4-positive helper T cell	5 studies	41% ± 14%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	53% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	51% ± 10%	Explore
exhausted T cell	5 studies	41% ± 10%	Explore
ionocyte	5 studies	58% ± 19%	Explore
platelet	5 studies	43% ± 21%	Explore
hematopoietic stem cell	5 studies	28% ± 7%	Explore
adventitial cell	5 studies	41% ± 13%	Explore
IgG plasma cell	5 studies	30% ± 5%	Explore
hematopoietic precursor cell	4 studies	34% ± 3%	Explore
deuterosomal cell	4 studies	40% ± 14%	Explore
squamous epithelial cell	4 studies	68% ± 11%	Explore
leukocyte	4 studies	46% ± 15%	Explore
podocyte	4 studies	32% ± 19%	Explore
Schwann cell	4 studies	52% ± 19%	Explore
glial cell	4 studies	32% ± 5%	Explore
intermediate monocyte	4 studies	64% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	49% ± 5%	Explore
granulocyte	4 studies	42% ± 10%	Explore
luminal cell of prostate epithelium	4 studies	33% ± 8%	Explore
T follicular helper cell	4 studies	30% ± 8%	Explore
keratinocyte	4 studies	57% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	43% ± 14%	Explore
duct epithelial cell	3 studies	48% ± 16%	Explore
hillock cell	3 studies	56% ± 24%	Explore
glomerular endothelial cell	3 studies	31% ± 9%	Explore
kidney loop of Henle epithelial cell	3 studies	39% ± 11%	Explore
extravillous trophoblast	3 studies	61% ± 26%	Explore
placental villous trophoblast	3 studies	47% ± 20%	Explore
tissue-resident macrophage	3 studies	35% ± 7%	Explore
myoepithelial cell	3 studies	44% ± 11%	Explore
muscle cell	3 studies	40% ± 16%	Explore
pancreatic ductal cell	3 studies	54% ± 25%	Explore
enteroendocrine cell	3 studies	21% ± 5%	Explore
T-helper 17 cell	3 studies	39% ± 8%	Explore
neutrophil	3 studies	32% ± 9%	Explore
hepatocyte	3 studies	42% ± 15%	Explore
T-helper 1 cell	3 studies	47% ± 13%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	48% ± 9%	Explore
double negative thymocyte	3 studies	53% ± 16%	Explore
erythrocyte	3 studies	33% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	36% ± 16%	Explore
peripheral blood	19 studies	49% ± 13%	Explore
intestine	10 studies	28% ± 12%	Explore
kidney	6 studies	35% ± 11%	Explore
heart	5 studies	20% ± 4%	Explore
uterus	5 studies	49% ± 23%	Explore
adipose	5 studies	44% ± 16%	Explore
breast	5 studies	39% ± 13%	Explore
liver	5 studies	24% ± 8%	Explore
placenta	4 studies	40% ± 23%	Explore
esophagus	4 studies	43% ± 20%	Explore
prostate	4 studies	21% ± 4%	Explore
bone marrow	3 studies	45% ± 12%	Explore
skin	3 studies	53% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	195975.96	1445 / 1445	99%	216.47	182 / 183
breast	100%	153512.33	459 / 459	98%	285.34	1099 / 1118
prostate	99%	81064.73	242 / 245	98%	180.98	494 / 502
uterus	100%	165129.02	170 / 170	93%	158.75	428 / 459
lung	100%	117002.25	577 / 578	90%	136.96	1043 / 1155
ovary	99%	97044.82	179 / 180	90%	98.04	385 / 430
skin	100%	204894.02	1809 / 1809	88%	120.50	417 / 472
bladder	100%	122174.81	21 / 21	86%	110.78	433 / 504
kidney	89%	44598.90	79 / 89	97%	218.92	873 / 901
thymus	97%	60791.14	632 / 653	89%	113.31	536 / 605
intestine	100%	177362.44	966 / 966	83%	94.04	440 / 527
stomach	94%	96966.68	338 / 359	86%	102.35	246 / 286
pancreas	11%	4076.53	37 / 328	97%	182.02	172 / 178
adipose	100%	169310.67	1204 / 1204	0%	0	0 / 0
blood vessel	100%	170971.69	1335 / 1335	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	84.18	1 / 1
muscle	99%	88406.06	795 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	239.90	43 / 45
spleen	95%	51282.39	229 / 241	0%	0	0 / 0
heart	91%	56847.00	785 / 861	0%	0	0 / 0
brain	11%	3990.53	295 / 2642	78%	76.64	552 / 705
liver	8%	2766.88	19 / 226	75%	59.88	305 / 406
eye	0%	0	0 / 0	81%	60.59	65 / 80
adrenal gland	33%	12527.74	86 / 258	43%	28.89	98 / 230
lymph node	0%	0	0 / 0	55%	52.06	16 / 29
peripheral blood	12%	4744.59	115 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1901385	Biological process	regulation of voltage-gated calcium channel activity
GO_1905686	Biological process	positive regulation of plasma membrane repair
GO_0043484	Biological process	regulation of RNA splicing
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0043034	Cellular component	costamere
GO_0016020	Cellular component	membrane
GO_0042383	Cellular component	sarcolemma
GO_0070062	Cellular component	extracellular exosome
GO_0044291	Cellular component	cell-cell contact zone
GO_0005925	Cellular component	focal adhesion
GO_0030315	Cellular component	T-tubule
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0098797	Cellular component	plasma membrane protein complex
GO_0005737	Cellular component	cytoplasm
GO_0031982	Cellular component	vesicle
GO_0005765	Cellular component	lysosomal membrane
GO_0005634	Cellular component	nucleus
GO_0045296	Molecular function	cadherin binding
GO_0097493	Molecular function	structural molecule activity conferring elasticity
GO_0003723	Molecular function	RNA binding
GO_0044548	Molecular function	S100 protein binding
GO_0005515	Molecular function	protein binding

Gene name	AHNAK
Protein name	Neuroblast differentiation-associated protein AHNAK (Desmoyokin) AHNAK protein AHNAK nucleoprotein
Synonyms	PM227
Description	FUNCTION: May be required for neuronal cell differentiation.
Accessions	Q09666 E9PKR9 Q96EC4 ENST00000257247.11 [Q09666-2] Q9BVU3 E9PJC6 E9PQE3 ENST00000533365.5 E9PJZ0 ENST00000378024.9 [Q09666-1] E9PLK4 ENST00000530285.5 ENST00000531324.1 ENST00000530124.5 ENST00000528508.5

AHNAK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review