ALOX15B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ALOX15B at tissue level.

III. Associated gene sets

GO_0010744Biological processpositive regulation of macrophage derived foam cell differentiation
GO_0032722Biological processpositive regulation of chemokine production
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0051122Biological processhepoxilin biosynthetic process
GO_0045786Biological processnegative regulation of cell cycle
GO_0043651Biological processlinoleic acid metabolic process
GO_2001303Biological processlipoxin A4 biosynthetic process
GO_0034440Biological processlipid oxidation
GO_0019372Biological processlipoxygenase pathway
GO_0035360Biological processpositive regulation of peroxisome proliferator activated receptor signaling pathway
GO_0030850Biological processprostate gland development
GO_0071926Biological processendocannabinoid signaling pathway
GO_1901696Biological processcannabinoid biosynthetic process
GO_0006915Biological processapoptotic process
GO_0006644Biological processphospholipid metabolic process
GO_0030336Biological processnegative regulation of cell migration
GO_0006629Biological processlipid metabolic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0045926Biological processnegative regulation of growth
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0030856Biological processregulation of epithelial cell differentiation
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005634Cellular componentnucleus
GO_0050473Molecular functionarachidonate 15-lipoxygenase activity
GO_0008289Molecular functionlipid binding
GO_1990136Molecular functionlinoleate 9S-lipoxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0036403Molecular functionarachidonate 8(S)-lipoxygenase activity
GO_0005509Molecular functioncalcium ion binding
GO_0016165Molecular functionlinoleate 13S-lipoxygenase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameALOX15B
Protein nameArachidonate 15-lipoxygenase type B
Polyunsaturated fatty acid lipoxygenase ALOX15B (15-lipoxygenase 2) (15-LOX-2) (Arachidonate 15-lipoxygenase B) (15-LOX-B) (EC 1.13.11.33) (Arachidonate 15-lipoxygenase type II) (Linoleate 13-lipoxygenase 15-LOb) (EC 1.13.11.-)
Synonyms
DescriptionFUNCTION: [Isoform A]: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (Probable). It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (Probable). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (Probable) . Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist . Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates . Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively down-regulate the immune response and have anti-aggregation properties with platelets . In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids . Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation . May also regulate cytokine secretion by macrophages and therefore play a role in the immune response . May also regulate macrophage differentiation into proatherogenic foam cells . .; FUNCTION: [Isoform B]: Does not convert arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. .

AccessionsI3L1D5
O15296
ENST00000380173.6 [O15296-4]
ENST00000380183.9 [O15296-1]
ENST00000573359.1 [O15296-2]
ENST00000572022.5