HSPB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006986Biological processresponse to unfolded protein
GO_0009408Biological processresponse to heat
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0061077Biological processchaperone-mediated protein folding
GO_0070527Biological processplatelet aggregation
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0045766Biological processpositive regulation of angiogenesis
GO_0009615Biological processresponse to virus
GO_1902176Biological processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0001932Biological processregulation of protein phosphorylation
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0035556Biological processintracellular signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0006446Biological processregulation of translational initiation
GO_0010506Biological processregulation of autophagy
GO_2001028Biological processpositive regulation of endothelial cell chemotaxis
GO_0042026Biological processprotein refolding
GO_0048010Biological processvascular endothelial growth factor receptor signaling pathway
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0035924Biological processcellular response to vascular endothelial growth factor stimulus
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0099641Biological processanterograde axonal protein transport
GO_0000502Cellular componentproteasome complex
GO_0005615Cellular componentextracellular space
GO_0005856Cellular componentcytoskeleton
GO_0030018Cellular componentZ disc
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0001533Cellular componentcornified envelope
GO_0005819Cellular componentspindle
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1904115Cellular componentaxon cytoplasm
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0043130Molecular functionubiquitin binding
GO_0044183Molecular functionprotein folding chaperone
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0051082Molecular functionunfolded protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0008426Molecular functionprotein kinase C inhibitor activity

IV. Literature review

[source]
Gene nameHSPB1
Protein namePutative heat shock protein family B member 1 isoform
Heat shock protein family B (small) member 1
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27)
Heat shock protein beta-1 (Heat shock 27 kDa protein)
Heat shock protein family B (small) member 1 (Putative heat shock protein family B member 1 isoform)
SynonymsHSP27
HSP28
DescriptionFUNCTION: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state . Plays a role in stress resistance and actin organization . Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins . .

AccessionsENST00000675538.1
ENST00000674547.1
ENST00000674650.1
A0A6Q8PH65
A0A6Q8PGK1
ENST00000676231.1
A0A6Q8PGY2
ENST00000675134.1
A0A6Q8PF43
C9J3N8
ENST00000248553.7
A0A6Q8PFE7
A0A8E9ZT92
ENST00000675906.1
ENST00000674965.1
A0A8E9ZUD7
ENST00000674638.1
ENST00000675226.1
ENST00000429938.1
P04792
A0A6Q8PHJ6
A0A6Q8PFK8
A0A6Q8PHA6