PDCD6IP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0045199Biological processmaintenance of epithelial cell apical/basal polarity
GO_0039702Biological processviral budding via host ESCRT complex
GO_0036258Biological processmultivesicular body assembly
GO_0046755Biological processviral budding
GO_1901673Biological processregulation of mitotic spindle assembly
GO_0016236Biological processmacroautophagy
GO_0000281Biological processmitotic cytokinesis
GO_0061952Biological processmidbody abscission
GO_1903543Biological processpositive regulation of exosomal secretion
GO_0090559Biological processregulation of membrane permeability
GO_0097734Biological processextracellular exosome biogenesis
GO_0006997Biological processnucleus organization
GO_0010824Biological processregulation of centrosome duplication
GO_0070830Biological processbicellular tight junction assembly
GO_0071985Biological processmultivesicular body sorting pathway
GO_0006915Biological processapoptotic process
GO_0015031Biological processprotein transport
GO_0000915Biological processactomyosin contractile ring assembly
GO_0090611Biological processubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
GO_1903553Biological processpositive regulation of extracellular exosome assembly
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_1903551Biological processregulation of extracellular exosome assembly
GO_0001772Cellular componentimmunological synapse
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_1903561Cellular componentextracellular vesicle
GO_0070062Cellular componentextracellular exosome
GO_0070971Cellular componentendoplasmic reticulum exit site
GO_0005925Cellular componentfocal adhesion
GO_0090543Cellular componentFlemming body
GO_0005829Cellular componentcytosol
GO_0005923Cellular componentbicellular tight junction
GO_0042641Cellular componentactomyosin
GO_0005768Cellular componentendosome
GO_0042470Cellular componentmelanosome
GO_0042803Molecular functionprotein homodimerization activity
GO_0031871Molecular functionproteinase activated receptor binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDCD6IP
Protein nameProgrammed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)
Programmed cell death 6 interacting protein
SynonymsKIAA1375
ALIX
AIP1
DescriptionFUNCTION: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes . The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis . Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis . May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP . By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity). .; FUNCTION: (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). .

AccessionsENST00000457054.6 [Q8WUM4-2]
Q8WUM4
ENST00000430877.5
F8WEQ7
ENST00000307296.8 [Q8WUM4-1]
ENST00000648706.1
A0A3B3IT07
F8WBR8
F8WDK9
C9IZF9
ENST00000435909.5
ENST00000413073.1
ENST00000412887.5