GO_0071985 | multivesicular body sorting pathway | OmnibusX

multivesicular body sorting pathway

I. Involved cell types

	Genes	Cell types	No. of supported studies
Group 1	CHMP4C CHMP1B VPS4B CHMP2A SNF8 VPS4A CHMP1A CHMP4A CHMP5 VTA1 CHMP2B PDCD6IP CHMP3	epithelial cell	5 studies
Group 2	CHMP4B RAB27B RAB27A EXPH5	epithelial cell	5 studies
Group 3	UVRAG SYTL4	endothelial cell astrocyte fibroblast	6 studies
Group 4	CHMP7 RUBCN MITD1	neuron epithelial cell	7 studies

II. Literature review

Name	multivesicular body sorting pathway
ID	GO_0071985
collection_id	Biological process
Description	A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.
External URL
Genes	CHMP4B CHMP2A RAB27B SNF8 CHMP1B EXPH5 CHMP6 CHMP2B CHMP4C UVRAG MITD1 CHMP3 vps4a-vps4b_human CHMP7 RAB27A VPS4A CHMP5 RUBCN escrt-iii_human PDCD6IP VPS4B VTA1 CHMP1A CHMP4A SYTL4