RAB27A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	33 studies	23% ± 5%	Explore
CD8-positive, alpha-beta T cell	25 studies	24% ± 9%	Explore
classical monocyte	15 studies	26% ± 11%	Explore
mature NK T cell	15 studies	21% ± 4%	Explore
T cell	14 studies	24% ± 6%	Explore
endothelial cell	13 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	24% ± 5%	Explore
gamma-delta T cell	11 studies	24% ± 5%	Explore
type II pneumocyte	10 studies	35% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	28% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	23% ± 6%	Explore
mucosal invariant T cell	10 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	24% ± 5%	Explore
regulatory T cell	9 studies	19% ± 3%	Explore
goblet cell	8 studies	46% ± 15%	Explore
CD4-positive, alpha-beta T cell	7 studies	22% ± 8%	Explore
type I pneumocyte	7 studies	25% ± 7%	Explore
monocyte	7 studies	26% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	23% ± 3%	Explore
T follicular helper cell	5 studies	31% ± 9%	Explore
lymphocyte	5 studies	32% ± 13%	Explore
vein endothelial cell	5 studies	26% ± 10%	Explore
neutrophil	5 studies	28% ± 15%	Explore
ciliated cell	5 studies	21% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	20% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	23% ± 6%	Explore
exhausted T cell	4 studies	40% ± 11%	Explore
epithelial cell	4 studies	24% ± 6%	Explore
retinal pigment epithelial cell	4 studies	36% ± 21%	Explore
innate lymphoid cell	4 studies	20% ± 4%	Explore
fibroblast	4 studies	21% ± 2%	Explore
club cell	4 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 7%	Explore
astrocyte	4 studies	37% ± 11%	Explore
leukocyte	3 studies	29% ± 7%	Explore
non-classical monocyte	3 studies	20% ± 5%	Explore
myeloid cell	3 studies	36% ± 5%	Explore
GABAergic neuron	3 studies	30% ± 9%	Explore
glutamatergic neuron	3 studies	33% ± 7%	Explore
endothelial cell of artery	3 studies	19% ± 6%	Explore
macrophage	3 studies	24% ± 5%	Explore
endothelial cell of lymphatic vessel	3 studies	19% ± 3%	Explore
T-helper 17 cell	3 studies	19% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	8 studies	19% ± 4%	Explore
peripheral blood	7 studies	21% ± 6%	Explore
bone marrow	4 studies	18% ± 3%	Explore
liver	4 studies	19% ± 2%	Explore
brain	4 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	4029.19	245 / 245	99%	70.07	498 / 502
esophagus	100%	2142.31	1443 / 1445	97%	19.86	178 / 183
lung	100%	4233.66	577 / 578	97%	31.37	1123 / 1155
skin	99%	1234.48	1798 / 1809	97%	67.91	460 / 472
thymus	100%	2361.99	653 / 653	96%	90.55	581 / 605
pancreas	99%	1510.33	326 / 328	97%	22.20	172 / 178
breast	100%	1710.96	459 / 459	93%	18.70	1037 / 1118
stomach	100%	3747.62	359 / 359	92%	19.09	262 / 286
uterus	100%	1676.16	170 / 170	89%	17.33	408 / 459
intestine	100%	2525.21	966 / 966	88%	16.43	465 / 527
adrenal gland	100%	3324.12	258 / 258	88%	36.32	202 / 230
liver	100%	2362.33	225 / 226	77%	12.72	312 / 406
bladder	100%	2230.38	21 / 21	76%	12.76	383 / 504
kidney	93%	1170.09	83 / 89	73%	12.52	658 / 901
ovary	94%	852.14	169 / 180	64%	8.21	277 / 430
lymph node	0%	0	0 / 0	100%	33.68	29 / 29
spleen	100%	3037.15	241 / 241	0%	0	0 / 0
blood vessel	100%	2903.38	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	6990.06	928 / 929	0%	0	0 / 0
adipose	100%	1774.13	1202 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	19.92	43 / 45
eye	0%	0	0 / 0	95%	47.62	76 / 80
heart	56%	440.92	482 / 861	0%	0	0 / 0
brain	32%	195.39	854 / 2642	18%	2.39	129 / 705
muscle	10%	68.36	84 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0043316	Biological process	cytotoxic T cell degranulation
GO_0050766	Biological process	positive regulation of phagocytosis
GO_0032400	Biological process	melanosome localization
GO_0097278	Biological process	complement-dependent cytotoxicity
GO_0010628	Biological process	positive regulation of gene expression
GO_0048489	Biological process	synaptic vesicle transport
GO_1903428	Biological process	positive regulation of reactive oxygen species biosynthetic process
GO_0007596	Biological process	blood coagulation
GO_0036257	Biological process	multivesicular body organization
GO_0009306	Biological process	protein secretion
GO_1903307	Biological process	positive regulation of regulated secretory pathway
GO_0032402	Biological process	melanosome transport
GO_0030318	Biological process	melanocyte differentiation
GO_0006887	Biological process	exocytosis
GO_0071985	Biological process	multivesicular body sorting pathway
GO_0043320	Biological process	natural killer cell degranulation
GO_0019882	Biological process	antigen processing and presentation
GO_1990182	Biological process	exosomal secretion
GO_1903435	Biological process	positive regulation of constitutive secretory pathway
GO_0045921	Biological process	positive regulation of exocytosis
GO_0070382	Cellular component	exocytic vesicle
GO_0016324	Cellular component	apical plasma membrane
GO_0005576	Cellular component	extracellular region
GO_0035580	Cellular component	specific granule lumen
GO_0001750	Cellular component	photoreceptor outer segment
GO_0005764	Cellular component	lysosome
GO_0070062	Cellular component	extracellular exosome
GO_0033093	Cellular component	Weibel-Palade body
GO_0005794	Cellular component	Golgi apparatus
GO_0030425	Cellular component	dendrite
GO_0033162	Cellular component	melanosome membrane
GO_0005829	Cellular component	cytosol
GO_0005770	Cellular component	late endosome
GO_0030141	Cellular component	secretory granule
GO_0032585	Cellular component	multivesicular body membrane
GO_0042470	Cellular component	melanosome
GO_0019003	Molecular function	GDP binding
GO_0019904	Molecular function	protein domain specific binding
GO_0003925	Molecular function	G protein activity
GO_0031489	Molecular function	myosin V binding
GO_0005525	Molecular function	GTP binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RAB27A
Protein name	Ras-related protein Rab-27A (EC 3.6.5.2) RAB27A, member RAS oncogene family Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram) Mutant Ras-related protein Rab-27A Ras-related protein Rab-27A
Synonyms	hCG_38865 RAB27
Description	FUNCTION: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion . Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. .
Accessions	H3BU81 H3BN55 A0A0H4JC20 ENST00000568803.1 ENST00000697642.1 [P51159-1] ENST00000564609.5 [P51159-1] ENST00000396307.6 [P51159-1] H3BVH7 ENST00000336787.6 [P51159-1] Q6IAS8 P51159 ENST00000566877.5 ENST00000567380.5 ENST00000565972.5 H3BS49 ENST00000563262.5 ENST00000697643.1 [P51159-1] A2RU94 H3BUD9 A0A7T5BNT6 ENST00000569493.5 [P51159-1]

RAB27A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review