RUBCN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010507Biological processnegative regulation of autophagy
GO_0045806Biological processnegative regulation of endocytosis
GO_0002376Biological processimmune system process
GO_0006914Biological processautophagy
GO_1901097Biological processnegative regulation of autophagosome maturation
GO_0071985Biological processmultivesicular body sorting pathway
GO_0006909Biological processphagocytosis
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005764Cellular componentlysosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0005770Cellular componentlate endosome
GO_0005769Cellular componentearly endosome
GO_0141039Molecular functionphosphatidylinositol 3-kinase inhibitor activity
GO_1901981Molecular functionphosphatidylinositol phosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRUBCN
Protein nameRun domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)
Rubicon autophagy regulator
KIAA0226 protein
SynonymsKIAA0226
DescriptionFUNCTION: Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation . .; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines . Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes . .

AccessionsENST00000296343.10 [Q92622-1]
ENST00000415452.5
H7C3H3
ENST00000707076.1
ENST00000447048.1
ENST00000474214.2
A0A9L9PY84
ENST00000449205.1
ENST00000273582.9 [Q92622-2]
H0Y6E6
A0A096LNI3
Q8N4U6
Q92622
ENST00000413360.5
H7C357
E9PEM3