CHMP6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHMP6 at tissue level.

III. Associated gene sets

GO_0001778Biological processplasma membrane repair
GO_0051469Biological processvesicle fusion with vacuole
GO_0042176Biological processregulation of protein catabolic process
GO_0039702Biological processviral budding via host ESCRT complex
GO_0036258Biological processmultivesicular body assembly
GO_0061763Biological processmultivesicular body-lysosome fusion
GO_1901673Biological processregulation of mitotic spindle assembly
GO_0016236Biological processmacroautophagy
GO_1903541Biological processregulation of exosomal secretion
GO_0043162Biological processubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0061952Biological processmidbody abscission
GO_0090148Biological processmembrane fission
GO_0006997Biological processnucleus organization
GO_0032511Biological processlate endosome to vacuole transport via multivesicular body sorting pathway
GO_0046761Biological processviral budding from plasma membrane
GO_1902774Biological processlate endosome to lysosome transport
GO_0071985Biological processmultivesicular body sorting pathway
GO_0006900Biological processvesicle budding from membrane
GO_0015031Biological processprotein transport
GO_0006914Biological processautophagy
GO_0007175Biological processnegative regulation of epidermal growth factor-activated receptor activity
GO_1904902Biological processESCRT III complex assembly
GO_0097352Biological processautophagosome maturation
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_0031468Biological processnuclear membrane reassembly
GO_0000815Cellular componentESCRT III complex
GO_0030496Cellular componentmidbody
GO_0005643Cellular componentnuclear pore
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0000776Cellular componentkinetochore
GO_0000421Cellular componentautophagosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0005828Cellular componentkinetochore microtubule
GO_0005829Cellular componentcytosol
GO_0005771Cellular componentmultivesicular body
GO_1904930Cellular componentamphisome membrane
GO_0010008Cellular componentendosome membrane
GO_0032585Cellular componentmultivesicular body membrane
GO_0005765Cellular componentlysosomal membrane
GO_0044877Molecular functionprotein-containing complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCHMP6
Protein nameCharged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20)
Charged multivesicular body protein 6
SynonymsVPS20
DescriptionFUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.

AccessionsENST00000572778.5
ENST00000325167.9
I3L3E4
ENST00000572525.5
Q96FZ7
I3L4G8
ENST00000571457.1
I3L4A1