Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 5165.62 | 1445 / 1445 | 100% | 61.01 | 183 / 183 |
| breast | 100% | 3264.75 | 459 / 459 | 100% | 66.99 | 1115 / 1118 |
| lung | 100% | 2491.70 | 576 / 578 | 100% | 52.65 | 1155 / 1155 |
| intestine | 100% | 3436.34 | 966 / 966 | 100% | 44.78 | 525 / 527 |
| bladder | 100% | 3072.43 | 21 / 21 | 100% | 47.66 | 502 / 504 |
| prostate | 100% | 2347.09 | 245 / 245 | 100% | 43.23 | 500 / 502 |
| uterus | 100% | 2865.31 | 170 / 170 | 100% | 55.53 | 457 / 459 |
| thymus | 100% | 2626.23 | 653 / 653 | 99% | 47.50 | 601 / 605 |
| stomach | 100% | 2376.73 | 359 / 359 | 99% | 44.27 | 284 / 286 |
| brain | 99% | 1967.39 | 2623 / 2642 | 100% | 36.31 | 704 / 705 |
| ovary | 100% | 1973.68 | 180 / 180 | 99% | 29.29 | 426 / 430 |
| kidney | 100% | 2002.90 | 89 / 89 | 98% | 39.01 | 885 / 901 |
| pancreas | 98% | 1484.23 | 320 / 328 | 99% | 39.48 | 177 / 178 |
| skin | 100% | 4474.79 | 1809 / 1809 | 96% | 40.98 | 453 / 472 |
| liver | 100% | 1643.34 | 226 / 226 | 95% | 21.51 | 384 / 406 |
| adrenal gland | 100% | 2239.77 | 258 / 258 | 93% | 31.78 | 214 / 230 |
| adipose | 100% | 3231.16 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3118.57 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 46.23 | 29 / 29 |
| spleen | 100% | 3025.19 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 72.88 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.34 | 1 / 1 |
| heart | 95% | 1199.77 | 817 / 861 | 0% | 0 | 0 / 0 |
| muscle | 91% | 1003.31 | 727 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 87% | 2382.52 | 807 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 83% | 20.32 | 66 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001778 | Biological process | plasma membrane repair |
| GO_0001525 | Biological process | angiogenesis |
| GO_0006813 | Biological process | potassium ion transport |
| GO_0060856 | Biological process | establishment of blood-brain barrier |
| GO_1903724 | Biological process | positive regulation of centriole elongation |
| GO_0039702 | Biological process | viral budding via host ESCRT complex |
| GO_0010971 | Biological process | positive regulation of G2/M transition of mitotic cell cycle |
| GO_0036258 | Biological process | multivesicular body assembly |
| GO_0061764 | Biological process | late endosome to lysosome transport via multivesicular body sorting pathway |
| GO_1901673 | Biological process | regulation of mitotic spindle assembly |
| GO_0016236 | Biological process | macroautophagy |
| GO_0043162 | Biological process | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO_0061952 | Biological process | midbody abscission |
| GO_0061738 | Biological process | late endosomal microautophagy |
| GO_1903543 | Biological process | positive regulation of exosomal secretion |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0090148 | Biological process | membrane fission |
| GO_0007033 | Biological process | vacuole organization |
| GO_0051261 | Biological process | protein depolymerization |
| GO_0006997 | Biological process | nucleus organization |
| GO_0010824 | Biological process | regulation of centrosome duplication |
| GO_0016197 | Biological process | endosomal transport |
| GO_0033993 | Biological process | response to lipid |
| GO_0046761 | Biological process | viral budding from plasma membrane |
| GO_0032510 | Biological process | endosome to lysosome transport via multivesicular body sorting pathway |
| GO_1903542 | Biological process | negative regulation of exosomal secretion |
| GO_0071985 | Biological process | multivesicular body sorting pathway |
| GO_1904903 | Biological process | ESCRT III complex disassembly |
| GO_0015031 | Biological process | protein transport |
| GO_0006914 | Biological process | autophagy |
| GO_0097352 | Biological process | autophagosome maturation |
| GO_0090611 | Biological process | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway |
| GO_0007080 | Biological process | mitotic metaphase chromosome alignment |
| GO_0031468 | Biological process | nuclear membrane reassembly |
| GO_0030301 | Biological process | cholesterol transport |
| GO_0030496 | Cellular component | midbody |
| GO_0031902 | Cellular component | late endosome membrane |
| GO_0005643 | Cellular component | nuclear pore |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0000922 | Cellular component | spindle pole |
| GO_0005813 | Cellular component | centrosome |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0090543 | Cellular component | Flemming body |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_1904949 | Cellular component | ATPase complex |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0005768 | Cellular component | endosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| Gene name | VPS4B |
| Protein name | Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) Vacuolar protein sorting 4 homolog B VPS4B protein |
| Synonyms | VPS42 SKD1 MIG1 |
| Description | FUNCTION: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission . Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan . .; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). . |
| Accessions | Q6PJZ4 O75351 ENST00000591519.1 ENST00000588059.5 ENST00000238497.10 K7EL71 K7EKZ3 |
