CHMP4C report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHMP4C at tissue level.

III. Associated gene sets

GO_0001778Biological processplasma membrane repair
GO_0051469Biological processvesicle fusion with vacuole
GO_0032466Biological processnegative regulation of cytokinesis
GO_0039702Biological processviral budding via host ESCRT complex
GO_0036258Biological processmultivesicular body assembly
GO_0009838Biological processabscission
GO_0061763Biological processmultivesicular body-lysosome fusion
GO_1901673Biological processregulation of mitotic spindle assembly
GO_0016236Biological processmacroautophagy
GO_0044878Biological processmitotic cytokinesis checkpoint signaling
GO_0043162Biological processubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0061952Biological processmidbody abscission
GO_0090148Biological processmembrane fission
GO_0006997Biological processnucleus organization
GO_0010824Biological processregulation of centrosome duplication
GO_0032511Biological processlate endosome to vacuole transport via multivesicular body sorting pathway
GO_0046761Biological processviral budding from plasma membrane
GO_1902774Biological processlate endosome to lysosome transport
GO_0071985Biological processmultivesicular body sorting pathway
GO_0006900Biological processvesicle budding from membrane
GO_0015031Biological processprotein transport
GO_0006914Biological processautophagy
GO_0097352Biological processautophagosome maturation
GO_0090611Biological processubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_0031468Biological processnuclear membrane reassembly
GO_0000815Cellular componentESCRT III complex
GO_0030496Cellular componentmidbody
GO_0005643Cellular componentnuclear pore
GO_0005886Cellular componentplasma membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0000776Cellular componentkinetochore
GO_0000421Cellular componentautophagosome membrane
GO_0090543Cellular componentFlemming body
GO_0005828Cellular componentkinetochore microtubule
GO_0005829Cellular componentcytosol
GO_0005771Cellular componentmultivesicular body
GO_1904930Cellular componentamphisome membrane
GO_0032585Cellular componentmultivesicular body membrane
GO_0005765Cellular componentlysosomal membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCHMP4C
Protein nameCharged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (SNF7 homolog associated with Alix 3) (SNF7-3) (hSnf7-3) (Vacuolar protein sorting-associated protein 32-3) (Vps32-3) (hVps32-3)
SynonymsSHAX3
DescriptionFUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission . ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan . .

AccessionsENST00000297265.5
Q96CF2