VPS4A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001778Biological processplasma membrane repair
GO_0032466Biological processnegative regulation of cytokinesis
GO_0039702Biological processviral budding via host ESCRT complex
GO_0036258Biological processmultivesicular body assembly
GO_0006998Biological processnuclear envelope organization
GO_0006622Biological processprotein targeting to lysosome
GO_0061764Biological processlate endosome to lysosome transport via multivesicular body sorting pathway
GO_0009838Biological processabscission
GO_0034058Biological processendosomal vesicle fusion
GO_0032880Biological processregulation of protein localization
GO_0032367Biological processintracellular cholesterol transport
GO_0061640Biological processcytoskeleton-dependent cytokinesis
GO_0016236Biological processmacroautophagy
GO_0044878Biological processmitotic cytokinesis checkpoint signaling
GO_0051301Biological processcell division
GO_0043162Biological processubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0061952Biological processmidbody abscission
GO_0061738Biological processlate endosomal microautophagy
GO_1903543Biological processpositive regulation of exosomal secretion
GO_0000916Biological processactomyosin contractile ring contraction
GO_0090148Biological processmembrane fission
GO_0007033Biological processvacuole organization
GO_0006997Biological processnucleus organization
GO_0016192Biological processvesicle-mediated transport
GO_0016197Biological processendosomal transport
GO_0046761Biological processviral budding from plasma membrane
GO_0007084Biological processmitotic nuclear membrane reassembly
GO_0071985Biological processmultivesicular body sorting pathway
GO_0006900Biological processvesicle budding from membrane
GO_0019076Biological processviral release from host cell
GO_0072319Biological processvesicle uncoating
GO_1904903Biological processESCRT III complex disassembly
GO_0006914Biological processautophagy
GO_1904896Biological processESCRT complex disassembly
GO_1903076Biological processregulation of protein localization to plasma membrane
GO_0097352Biological processautophagosome maturation
GO_0090611Biological processubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_0031468Biological processnuclear membrane reassembly
GO_1903774Biological processpositive regulation of viral budding via host ESCRT complex
GO_0030496Cellular componentmidbody
GO_0031902Cellular componentlate endosome membrane
GO_0005643Cellular componentnuclear pore
GO_0005886Cellular componentplasma membrane
GO_0000922Cellular componentspindle pole
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005769Cellular componentearly endosome
GO_0005813Cellular componentcentrosome
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0090543Cellular componentFlemming body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005770Cellular componentlate endosome
GO_1904949Cellular componentATPase complex
GO_0005774Cellular componentvacuolar membrane
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0140545Molecular functionATP-dependent protein disaggregase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameVPS4A
Protein nameVPS4A protein
Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4)
SynonymsVPS4
DescriptionFUNCTION: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. It is required for proper accomplishment of various processes including the regulation of endosome size, primary cilium organization, mitotic spindle organization, chromosome segregation, and nuclear envelope sealing and spindle disassembly during anaphase . Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphorylation of CHMP4C, leading to abscission . VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan . Critical for normal erythroblast cytokinesis and correct erythropoiesis . .; FUNCTION: (Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). .

AccessionsENST00000254950.13
Q49AN7
Q9UN37