VTA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0016236Biological processmacroautophagy
GO_0032511Biological processlate endosome to vacuole transport via multivesicular body sorting pathway
GO_0036258Biological processmultivesicular body assembly
GO_0071985Biological processmultivesicular body sorting pathway
GO_1904903Biological processESCRT III complex disassembly
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005771Cellular componentmultivesicular body
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVTA1
Protein nameVacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1)
Vesicle trafficking 1
Chromosome 6 open reading frame 55, isoform CRA_b (Vesicle trafficking 1)
SynonymsHSPC228
C6orf55
hCG_18120
My012
DescriptionFUNCTION: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding. .

AccessionsENST00000452973.6 [Q9NP79-2]
A0A087WY55
Q9NP79
ENST00000367621.1
ENST00000367630.9 [Q9NP79-1]
Q5TGM0
ENST00000620996.4