CHMP1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001778Biological processplasma membrane repair
GO_0051469Biological processvesicle fusion with vacuole
GO_0039702Biological processviral budding via host ESCRT complex
GO_0036258Biological processmultivesicular body assembly
GO_0010629Biological processnegative regulation of gene expression
GO_0061763Biological processmultivesicular body-lysosome fusion
GO_1901673Biological processregulation of mitotic spindle assembly
GO_0045324Biological processlate endosome to vacuole transport
GO_0051301Biological processcell division
GO_0043162Biological processubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0061952Biological processmidbody abscission
GO_0090148Biological processmembrane fission
GO_0006997Biological processnucleus organization
GO_0016192Biological processvesicle-mediated transport
GO_0010824Biological processregulation of centrosome duplication
GO_0046761Biological processviral budding from plasma membrane
GO_1902774Biological processlate endosome to lysosome transport
GO_0032509Biological processendosome transport via multivesicular body sorting pathway
GO_0071985Biological processmultivesicular body sorting pathway
GO_1904903Biological processESCRT III complex disassembly
GO_0007076Biological processmitotic chromosome condensation
GO_0015031Biological processprotein transport
GO_0006914Biological processautophagy
GO_0097352Biological processautophagosome maturation
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_0031468Biological processnuclear membrane reassembly
GO_0000815Cellular componentESCRT III complex
GO_0030496Cellular componentmidbody
GO_0005643Cellular componentnuclear pore
GO_0005886Cellular componentplasma membrane
GO_0012505Cellular componentendomembrane system
GO_0005769Cellular componentearly endosome
GO_0000776Cellular componentkinetochore
GO_0005815Cellular componentmicrotubule organizing center
GO_0000421Cellular componentautophagosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0016363Cellular componentnuclear matrix
GO_0005828Cellular componentkinetochore microtubule
GO_0005829Cellular componentcytosol
GO_0005771Cellular componentmultivesicular body
GO_1904930Cellular componentamphisome membrane
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0032585Cellular componentmultivesicular body membrane
GO_0005765Cellular componentlysosomal membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0019904Molecular functionprotein domain specific binding
GO_0008237Molecular functionmetallopeptidase activity
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCHMP1A
Protein nameCharged multivesicular body protein 1a (Chromatin-modifying protein 1a)
Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1)
Charged multivesicular body protein 1A
SynonymsCHMP1
KIAA0047
PRSM1
PCOLN3
DescriptionFUNCTION: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. .

AccessionsA0A6Q8PHU0
ENST00000674799.1
A0A6Q8PGM8
Q9HD42
A0A6Q8PG85
ENST00000675942.1
A0A6Q8PGI9
ENST00000550102.5
F8VUA2
ENST00000675909.1
F5H875
ENST00000535997.7
ENST00000675778.1
ENST00000549328.2
A0A6Q8PF26
ENST00000675309.1
A0A6Q8PF35
ENST00000676355.1
ENST00000676118.1
A0A6Q8PFF8
ENST00000676402.1
F8VVT7
A0A6Q8PFX8
ENST00000397901.8 [Q9HD42-1]
ENST00000675536.1
ENST00000675016.1
A0A6Q8PGV2
A0A6Q8PFF9
ENST00000675161.1