UVRAG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0006890Biological processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO_0007059Biological processchromosome segregation
GO_0051684Biological processmaintenance of Golgi location
GO_0071900Biological processregulation of protein serine/threonine kinase activity
GO_0035493Biological processSNARE complex assembly
GO_0097680Biological processdouble-strand break repair via classical nonhomologous end joining
GO_0007098Biological processcentrosome cycle
GO_0046718Biological processsymbiont entry into host cell
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_0010506Biological processregulation of autophagy
GO_0071985Biological processmultivesicular body sorting pathway
GO_0006914Biological processautophagy
GO_1901098Biological processpositive regulation of autophagosome maturation
GO_0097352Biological processautophagosome maturation
GO_0032801Biological processreceptor catabolic process
GO_0032465Biological processregulation of cytokinesis
GO_0007051Biological processspindle organization
GO_0000775Cellular componentchromosome, centromeric region
GO_0030496Cellular componentmidbody
GO_0005769Cellular componentearly endosome
GO_0035032Cellular componentphosphatidylinositol 3-kinase complex, class III
GO_0005813Cellular componentcentrosome
GO_0005764Cellular componentlysosome
GO_0000421Cellular componentautophagosome membrane
GO_0000323Cellular componentlytic vacuole
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0045335Cellular componentphagocytic vesicle
GO_0070418Cellular componentDNA-dependent protein kinase complex
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0005768Cellular componentendosome
GO_0000149Molecular functionSNARE binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameUVRAG
Protein nameUV radiation resistance-associated gene protein (p63)
UV radiation resistance associated
UV radiation resistance associated protein
Synonyms
DescriptionFUNCTION: Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) . During autophagy acts as a regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3 . Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2 . Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events . Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion . In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly . .; FUNCTION: Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) . Required for centrosome stability and proper chromosome segregation . .

AccessionsQ9P2Y5
E9PK00
ENST00000528420.5
Q6P1X0
ENST00000531818.5 [Q9P2Y5-2]
ENST00000532130.1 [Q9P2Y5-2]
ENST00000528264.1
ENST00000525183.1
ENST00000533454.5 [Q9P2Y5-2]
ENST00000356136.8 [Q9P2Y5-1]
E9PR71
H0YDD1