Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| lung | 7 studies | 27% ± 13% | |
| peripheral blood | 6 studies | 20% ± 5% | |
| brain | 5 studies | 25% ± 6% | |
| pancreas | 4 studies | 35% ± 7% | |
| intestine | 4 studies | 20% ± 6% | |
| eye | 3 studies | 21% ± 5% | |
| uterus | 3 studies | 25% ± 12% | |
| prostate | 3 studies | 30% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 100% | 1985.75 | 359 / 359 | 100% | 26.16 | 286 / 286 |
| lung | 100% | 2399.70 | 578 / 578 | 100% | 21.64 | 1154 / 1155 |
| breast | 100% | 2734.95 | 459 / 459 | 100% | 26.06 | 1117 / 1118 |
| prostate | 100% | 2898.32 | 245 / 245 | 100% | 26.36 | 501 / 502 |
| ovary | 100% | 2660.04 | 180 / 180 | 100% | 16.53 | 429 / 430 |
| brain | 100% | 2024.04 | 2632 / 2642 | 100% | 18.45 | 705 / 705 |
| uterus | 100% | 3000.81 | 170 / 170 | 100% | 20.62 | 457 / 459 |
| esophagus | 100% | 2818.51 | 1445 / 1445 | 99% | 20.86 | 182 / 183 |
| bladder | 100% | 2836.05 | 21 / 21 | 99% | 27.07 | 501 / 504 |
| thymus | 100% | 3396.79 | 653 / 653 | 99% | 27.86 | 601 / 605 |
| intestine | 100% | 3111.26 | 966 / 966 | 99% | 28.50 | 523 / 527 |
| pancreas | 100% | 1626.39 | 327 / 328 | 99% | 26.61 | 177 / 178 |
| kidney | 100% | 2214.36 | 89 / 89 | 97% | 15.60 | 876 / 901 |
| liver | 100% | 1459.75 | 226 / 226 | 95% | 11.18 | 386 / 406 |
| skin | 100% | 2705.96 | 1808 / 1809 | 94% | 15.39 | 442 / 472 |
| adrenal gland | 100% | 2215.67 | 258 / 258 | 91% | 10.57 | 209 / 230 |
| adipose | 100% | 2748.04 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3817.53 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 13.38 | 29 / 29 |
| muscle | 100% | 2121.92 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1754.58 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 16.77 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.71 | 1 / 1 |
| heart | 96% | 1716.23 | 825 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 93% | 1744.75 | 862 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 46% | 3.42 | 37 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001778 | Biological process | plasma membrane repair |
| GO_0051469 | Biological process | vesicle fusion with vacuole |
| GO_0039702 | Biological process | viral budding via host ESCRT complex |
| GO_0050804 | Biological process | modulation of chemical synaptic transmission |
| GO_0036258 | Biological process | multivesicular body assembly |
| GO_0061763 | Biological process | multivesicular body-lysosome fusion |
| GO_1901673 | Biological process | regulation of mitotic spindle assembly |
| GO_0045324 | Biological process | late endosome to vacuole transport |
| GO_0016236 | Biological process | macroautophagy |
| GO_0043162 | Biological process | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO_0061952 | Biological process | midbody abscission |
| GO_0090148 | Biological process | membrane fission |
| GO_0006997 | Biological process | nucleus organization |
| GO_0070050 | Biological process | neuron cellular homeostasis |
| GO_0010824 | Biological process | regulation of centrosome duplication |
| GO_0046761 | Biological process | viral budding from plasma membrane |
| GO_1902774 | Biological process | late endosome to lysosome transport |
| GO_0007032 | Biological process | endosome organization |
| GO_0032509 | Biological process | endosome transport via multivesicular body sorting pathway |
| GO_0071985 | Biological process | multivesicular body sorting pathway |
| GO_0019076 | Biological process | viral release from host cell |
| GO_1904903 | Biological process | ESCRT III complex disassembly |
| GO_0050890 | Biological process | cognition |
| GO_0015031 | Biological process | protein transport |
| GO_0006914 | Biological process | autophagy |
| GO_0097352 | Biological process | autophagosome maturation |
| GO_0099159 | Biological process | regulation of modification of postsynaptic structure |
| GO_0007080 | Biological process | mitotic metaphase chromosome alignment |
| GO_0031468 | Biological process | nuclear membrane reassembly |
| GO_0099175 | Biological process | regulation of postsynapse organization |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0000815 | Cellular component | ESCRT III complex |
| GO_0030496 | Cellular component | midbody |
| GO_0005643 | Cellular component | nuclear pore |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0000776 | Cellular component | kinetochore |
| GO_0005764 | Cellular component | lysosome |
| GO_0000421 | Cellular component | autophagosome membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005828 | Cellular component | kinetochore microtubule |
| GO_0005829 | Cellular component | cytosol |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0005770 | Cellular component | late endosome |
| GO_0005771 | Cellular component | multivesicular body |
| GO_0005737 | Cellular component | cytoplasm |
| GO_1904930 | Cellular component | amphisome membrane |
| GO_0005768 | Cellular component | endosome |
| GO_0032585 | Cellular component | multivesicular body membrane |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0019904 | Molecular function | protein domain specific binding |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CHMP2B |
| Protein name | Chromatin modifying protein 2B (cDNA FLJ11303 fis, clone PLACE1009995, highly similar to Charged multivesicular body protein 2b) (cDNA FLJ11318 fis, clone PLACE1010274, highly similar to Charged multivesicular body protein 2b) (cDNA, FLJ95104) Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2) Charged multivesicular body protein 2B |
| Synonyms | hCG_27849 CGI-84 |
| Description | FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. |
| Accessions | C9J0A7 ENST00000494980.5 ENST00000471660.5 [Q9UQN3-2] ENST00000676705.1 Q9UQN3 A0A087WW88 B2RE76 ENST00000263780.9 [Q9UQN3-1] ENST00000472024.3 |
