SNF8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042176Biological processregulation of protein catabolic process
GO_0036258Biological processmultivesicular body assembly
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0061635Biological processregulation of protein complex stability
GO_0010628Biological processpositive regulation of gene expression
GO_0016236Biological processmacroautophagy
GO_1903543Biological processpositive regulation of exosomal secretion
GO_0032456Biological processendocytic recycling
GO_0090148Biological processmembrane fission
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0043405Biological processregulation of MAP kinase activity
GO_0071985Biological processmultivesicular body sorting pathway
GO_0045022Biological processearly endosome to late endosome transport
GO_0043328Biological processprotein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0000814Cellular componentESCRT II complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0008289Molecular functionlipid binding
GO_0016247Molecular functionchannel regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSNF8
Protein nameVacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22)
Vacuolar-sorting protein SNF8 (ESCRT-II complex subunit VPS22)
SNF8 subunit of ESCRT-II
SynonymsEAP30
DescriptionFUNCTION: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan . .

AccessionsD6RBI1
K7EPV2
ENST00000502492.6 [Q96H20-1]
H0Y8S5
I3L457
ENST00000290330.7 [Q96H20-2]
D6RJ86
ENST00000507302.6
D6RFY6
ENST00000576353.5
ENST00000573795.5
Q96H20
ENST00000509989.5
I3L2X5
ENST00000510558.6
ENST00000509995.5
ENST00000514929.1