SENP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097190Biological processapoptotic signaling pathway
GO_0016925Biological processprotein sumoylation
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0016926Biological processprotein desumoylation
GO_0043488Biological processregulation of mRNA stability
GO_0006508Biological processproteolysis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0031965Cellular componentnuclear membrane
GO_0005925Cellular componentfocal adhesion
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004175Molecular functionendopeptidase activity
GO_0016929Molecular functiondeSUMOylase activity
GO_0005515Molecular functionprotein binding
GO_0070139Molecular functionSUMO-specific endopeptidase activity

IV. Literature review

[source]
Gene nameSENP1
Protein nameSUMO specific peptidase 1
Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1)
Synonyms
DescriptionFUNCTION: Protease that catalyzes two essential functions in the SUMO pathway . The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 . Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity . Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity . Deconjugates SUMO2 from MTA1 . Deconjugates SUMO1 from METTL3 . Desumoylates CCAR2 which decreases its interaction with SIRT1 . Deconjugates SUMO1 from GPS2 . .

AccessionsENST00000552189.5
ENST00000549518.6 [Q9P0U3-1]
F8VRZ8
ENST00000448372.6 [Q9P0U3-1]
F8W0I8
ENST00000551798.1
Q9P0U3
ENST00000549595.5 [Q9P0U3-2]