PVR report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PVR at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PVR at tissue level.

III. Associated gene sets

GO_0060370Biological processsusceptibility to T cell mediated cytotoxicity
GO_0002860Biological processpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO_0046718Biological processsymbiont entry into host cell
GO_0042271Biological processsusceptibility to natural killer cell mediated cytotoxicity
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0045954Biological processpositive regulation of natural killer cell mediated cytotoxicity
GO_0005615Cellular componentextracellular space
GO_0009986Cellular componentcell surface
GO_0005912Cellular componentadherens junction
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005925Cellular componentfocal adhesion
GO_0050839Molecular functioncell adhesion molecule binding
GO_0038023Molecular functionsignaling receptor activity
GO_0005515Molecular functionprotein binding
GO_0001618Molecular functionvirus receptor activity

IV. Literature review

[source]
Gene namePVR
Protein namePoliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)
PVR cell adhesion molecule
PVR cell adhesion molecule (Poliovirus receptor, isoform CRA_c)
SynonymsPVS
hCG_1996181
DescriptionFUNCTION: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. .; FUNCTION: (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. .; FUNCTION: (Microbial infection) Acts as a receptor for Pseudorabies virus. .; FUNCTION: (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells. .

AccessionsP15151
ENST00000706604.1
ENST00000706606.1
ENST00000403059.8 [P15151-2]
ENST00000706607.1
A0A9L9PY64
A0A9L9PX39
K7EMC6
ENST00000406449.8
F8W7D4
A0A9L9PXN8
ENST00000706603.1
ENST00000344956.8 [P15151-3]
A0A0C4DG49
ENST00000425690.8
ENST00000187830.2
A0A0A0MSA9
A0A9L9PXB8
ENST00000587785.1