TRIOBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_0007605Biological processsensory perception of sound
GO_0060088Biological processauditory receptor cell stereocilium organization
GO_0051301Biological processcell division
GO_0051016Biological processbarbed-end actin filament capping
GO_0030047Biological processactin modification
GO_0005813Cellular componentcentrosome
GO_0015629Cellular componentactin cytoskeleton
GO_0030496Cellular componentmidbody
GO_0000781Cellular componentchromosome, telomeric region
GO_0005925Cellular componentfocal adhesion
GO_0120044Cellular componentstereocilium base
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0045159Molecular functionmyosin II binding
GO_0051015Molecular functionactin filament binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameTRIOBP
Protein nameTRIO and F-actin binding protein
TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin)
TRIO and F-actin-binding protein
SynonymsTARA
HRIHFB2122
KIAA1662
DescriptionFUNCTION: [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization . May also serve as a linker protein to recruit proteins required for F-actin formation and turnover . Essential for correct mitotic progression . .; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. .; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. .

AccessionsF6WMF4
ENST00000418339.5
F6WYE2
ENST00000428075.5
H7BXW4
F6TR96
ENST00000344404.10
ENST00000407319.7 [Q9H2D6-6]
ENST00000452519.5
ENST00000417857.1
H0Y5J9
ENST00000403663.6 [Q9H2D6-7]
H0Y5T8
Q9H2D6
ENST00000413051.2
ENST00000644935.1 [Q9H2D6-1]
A0A1S5UZ31